1. Mutagenicity of lichen constituents.
- Author
-
Shibamoto T and Wei CI
- Subjects
- Animals, Benzofurans isolation & purification, Dibenzoxepins isolation & purification, Mutagenicity Tests, Salmonella typhimurium drug effects, Structure-Activity Relationship, Benzofurans toxicity, Dibenzoxepins toxicity, Lichens, Mutagens toxicity, Mutation
- Abstract
Usnic acid (the most abundant lichen constituents), physodic, and physodalic acids isolated from Hypogymnia enteromorph (Ach.) Nyl. were tested for mutagenicity in the Ames Salmonella/microsome assay. Physodalic acid exhibited clear dose-related mutagenicity against Salmonella typhimurium strain TA 100 with or without S9 mix in both plate-incorporation and preincubation assays. The addition of S9 mix increased the number of revertants approximately threefold and fourfold in preincubation and plate-incorporation assays, respectively.
- Published
- 1984
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