1. Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort.
- Author
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Deen, Laura, Clark, Alice, Hougaard, Karin Sørig, Petersen, Kajsa Ugelvig, Frederiksen, Marie, Wise, Lauren A., Wesselink, Amelia K., Meyer, Harald William, Bonde, Jens Peter, and Tøttenborg, Sandra Søgaard
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TYPE 2 diabetes , *POLYCHLORINATED biphenyls , *APARTMENTS , *RESIDENTIAL areas - Abstract
Previous research indicates an association between higher-chlorinated polychlorinated biphenyls (PCBs) and type 2 diabetes (T2D). However, less is known about the extent to which PCB exposure in indoor air, composed primarily of lower-chlorinated PCBs, affects T2D risk. We assessed the association between indoor air exposure to PCBs in residential buildings and T2D incidence. The register-based 'Health Effects of PCBs in Indoor Air' (HESPAIR) cohort comprises 51,921 Danish residents of two residential areas with apartments built with and without PCB-containing materials (reference apartments). We assessed exposure status by combining register-based information on relocation history with extrapolated values of exposure based on PCB-measurements in indoor air from subsets of the apartments. T2D cases were identified in the Danish registers during 1977–2018. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression analyses with time-varying exposure. We identified 2737 incident T2D cases during the follow-up. Exposure to ≥3300 ng/m3 PCB × year (3rd tertile of PCB year) was associated with higher risk of T2D (HR 1.15, 95% CI 1.02–1.30) compared with exposure to <300 ng/m3 PCB × year (reference). However, among individuals with lower cumulated PCB year , the risk was similar to residents with exposure <300 ng/m3 PCB × year (300–899 ng/m3 PCB × year: HR 0.98, 95% CI 0.87–1.11; 900–3299 ng/m3 PCB × year: HR 0.96, 95% CI 0.83–1.10). We observed a marginally higher risk of T2D, but there was no evidence of an exposure-response relationship. The results should be interpreted with caution until confirmed in other independent studies of PCB exposure in indoor air. • Residents may be exposed to PCBs in indoor air in their private homes • Airborne PCB exposure has previously been associated with type 2 diabetes • PCB exposure in indoor air is associated with slightly higher type 2 diabetes risk [ABSTRACT FROM AUTHOR]
- Published
- 2023
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