Search

Your search keyword '"Bjørklund, Geir"' showing total 14 results
Start Over Author "Bjørklund, Geir" Journal environmental research
14 results on '"Bjørklund, Geir"'

6. Cadmium and atherosclerosis: A review of toxicological mechanisms and a meta-analysis of epidemiologic studies

Author

Tinkov, Alexey A., primary, Filippini, Tommaso, additional, Ajsuvakova, Olga P., additional, Skalnaya, Margarita G., additional, Aaseth, Jan, additional, Bjørklund, Geir, additional, Gatiatulina, Eugenia R., additional, Popova, Elizaveta V., additional, Nemereshina, Olga N., additional, Huang, Pai-Tsang, additional, Vinceti, Marco, additional, and Skalny, Anatoly V., additional

Published
2018
Full Text
View/download PDF

14. Cadmium and atherosclerosis: A review of toxicological mechanisms and a meta-analysis of epidemiologic studies.

Author

Skalny, Anatoly V., Tinkov, Alexey A., Popova, Elizaveta V., Huang, Pai-Tsang, Skalnaya, Margarita G., Filippini, Tommaso, Vinceti, Marco, Ajsuvakova, Olga P., Aaseth, Jan, Bjørklund, Geir, Gatiatulina, Eugenia R., and Nemereshina, Olga N.

Subjects
*CADMIUM poisoning, *ATHEROSCLEROSIS risk factors, *PHYSIOLOGICAL effects of cadmium, *EPIDEMIOLOGY, *OXIDATIVE stress, *INFLAMMATION, *META-analysis
Abstract

Cadmium has been proposed to be the one of the factors of atherosclerosis development, although the existing data are still controversial. The primary objective of the present study is the review and the meta-analysis of studies demonstrating the association between Cd exposure and atherosclerosis as well as review of the potential mechanisms of such association. We performed a systematic search in the PubMed-Medline database using the MeSH terms cadmium, cardiovascular disease, atherosclerosis, coronary artery disease, myocardial infarction, stroke, mortality and humans up through December 20, 2017. Elevated urinary Cd levels were associated with increased mortality for cardiovascular disease (HR = 1.34, 95% CI: 1.07–1.67) as well as elevated blood Cd levels (HR = 1.78, 95% CI: 1.24–2.56). Analysis restricted to never smokers showed similar, though more imprecise, results. Consistently, we also observed an association between Cd exposure markers (blood and urine) and coronary heart disease, stroke, and peripheral artery disease. Moreover, Cd exposure was associated with atherogenic changes in lipid profile. High Cd exposure was associated with higher TC levels (OR = 1.48, 95% CI: 1.10–2.01), higher LDL-C levels (OR = 1.31, 95% CI 0.99–1.73) and lower HDL-C levels (OR = 1.96, 95% CI: 1.09–3.55). The mechanisms of atherogenic effect of cadmium may involve oxidative stress, inflammation, endothelial dysfunction, enhanced lipid synthesis, up-regulation of adhesion molecules, prostanoid dysbalance, as well as altered glycosaminoglycan synthesis. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results