1. Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status
- Author
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Nadine Khoury, María Ángeles Martínez, Indira Paz-Graniel, Miguel Ángel Martínez-González, Dolores Corella, Olga Castañer, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, J. Lluís Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Sergio Cinza Sanjurjo, Xavier Pintó, José Juan Gaforio, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Carmen Sayon-Orea, Jose V. Sorlí, Karla-Alejandra Pérez-Vega, Antonio Garcia-Rios, Nuria Gómez Bellvert, Enrique Gómez-Gracia, M.A. Zulet, Alice Chaplin, Rosa Casas, Inmaculada Salcedo-Bellido, Lucas Tojal-Sierra, Maria-Rosa Bernal-Lopez, Zenaida Vázquez-Ruiz, Eva M. Asensio, Albert Goday, Patricia J. Peña-Orihuela, Antonio J. Signes-Pastor, Ana Garcia-Arellano, Montse Fitó, Nancy Babio, and Jordi Salas-Salvadó
- Subjects
Polychlorinated dibenzo-p-furans (PCDD/F) ,Obesity ,Abdominal obesity ,Endocrine disrupting chemicals ,Biochemistry ,Adiposity ,General Environmental Science - Abstract
dibenzop- furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55–75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend, nstituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund PI16/01120 PI17/00764 PI17/01183 PI17/00855 PI17/01347 PI17/00525 PI17/01827 PI17/00532 PI17/00215 PI17/01441 PI17/00508 PI17/01732 PI17/00926 PI19/00957 PI19/00386 PI19/00309 PI19/01032 PI19/00576 PI19/00017 PI19/01226 PI19/00781 PI19/01560 PI19/01332 PI20/01802 PI20/00138 PI20/01532 PI20/00456 PI20/00339 PI20/00557 PI20/00886 PI20/01158, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant, European Research Council (ERC) European Commission 340918, La Caixa Foundation 2013ACUP00194, Junta de Andalucia PI0458/2013 PS0358/2016 PI0137/2018, Center for Forestry Research & Experimentation (CIEF) PROMETEO/21/2021, MICIN/AEI/FEDER, UE CEX2021-001234-M, SEMERGEN grant, ICREA under the ICREA Academia program, Agencia de Gestio d'Ajuts Universitaris de Recerca (AGAUR FI) 2021FI_B 00145
- Published
- 2023
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