1. Effects of genetic polymorphisms on antioxidant status and concentrations of the metals in the blood of riverside Amazonian communities co-exposed to Hg and Pb
- Author
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Marcelo Tempesta de Oliveira, Andréia Ávila Soares de Oliveira, Marilesia Ferreira de Souza, Rossana Batista de Oliveira Godoy Camargo, Fernando Barbosa, Gilberto U.L. Braga, Solange Cristina Garcia, Ilce Mara de Syllos Cólus, André van Helvoort Lengert, Juliana Valentini, Joseph A. Adeyemi, Gustavo Rafael Mazzaron Barcelos, and Denise Grotto
- Subjects
Adult ,Male ,medicine.medical_specialty ,GPX1 ,Adolescent ,Population ,Biology ,Biochemistry ,Calcitriol receptor ,Antioxidants ,GSTP1 ,Young Adult ,Internal medicine ,Genotype ,medicine ,Humans ,education ,General Environmental Science ,Aged ,Aged, 80 and over ,education.field_of_study ,Polymorphism, Genetic ,GCLM ,Environmental Exposure ,Methylmercury Compounds ,Middle Aged ,Endocrinology ,GCLC ,Cross-Sectional Studies ,Lead ,Immunology ,Toxicity ,Environmental Pollutants ,Female ,Brazil ,Environmental Monitoring - Abstract
There have been reports of genetic effects affecting the metabolism of Hg and Pb individually, and thus modulating their toxicities. However, there is still a knowledge gap with respect to how genetics may influence the toxicities of these toxic metals during a co-exposure scenario. This present study is therefore aimed at investigating the effects of polymorphisms in genes (GSTM1, GSTT1, GSTP1, GCLM, GCLC, GPx1, ALAD, VDR and MDR1) that have been implicated in Hg and Pb metabolisms affects the kinetics of these metals, as well as various blood antioxidant status parameters: MDA and GSH, and the activities of CAT, GPx and ALAD among populations that have been co-exposed to both Hg and Pb. Study subjects (207 men; 188 women) were from an Amazonian population in Brazil, exposed to Hg and Pb from diet. The blood levels of Hg and Pb were determined by ICP-MS while genotyping were performed by PCR assays. The median values of Hg and Pb in blood were 39.8µg/L and 11.0µg/dL, respectively. GSTM1, ALAD and VDR polymorphisms influenced Hg in blood (β=0.17; 0.37 and 0.17; respectively, p
- Published
- 2014