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8 results on '"Jianqing Zhang"'

4. Elevated Body Burdens of PBDEs, Dioxins, and PCBs on Thyroid Hormone Homeostasis at an Electronic Waste Recycling Site in China

Author

Bin Wu, Feina Lu, Zhaoqiong Peng, Yousheng Jiang, Haiyan Huang, Daokui Fang, Jianqing Zhang, Yin Liang, Jian Zhou, Cai He, Bin Liu, and Chunlei Wang

Subjects
China, Conservation of Natural Resources, Thyroid Hormones, endocrine system, medicine.medical_specialty, Polychlorinated dibenzodioxins, Dioxins, chemistry.chemical_compound, Polybrominated diphenyl ethers, Blood serum, Pregnancy, Internal medicine, Halogenated Diphenyl Ethers, medicine, Homeostasis, Humans, Environmental Chemistry, Persistent organic pollutant, Chemistry, Thyroid, General Chemistry, Polychlorinated Biphenyls, medicine.anatomical_structure, Endocrinology, Environmental chemistry, Cord blood, Female, Electronics, Polychlorinated dibenzofurans, Hormone
Abstract

A cross-sectional study of 25 sample sets (each set consisted of maternal serum and cord whole blood) from 50 pregnant women in zone A (n = 25 from exposed group) and zone B (n = 25 from reference group) was conducted to examine the association between thyroid hormone (TH) levels and PBDE, PCDD/F, and PCB exposures. Thyroid hormones TT3, TT4, and TSH levels were measured in maternal serum at 16 weeks of gestation. The concentrations of PBDEs, PCDD/Fs, and PCBs were determined by isotope dilution HRGC/HRMS in cord blood samples. Body burdens of the three contaminants in cord blood in zone A (median: summation sigma TEQ-PCDD/Fs 0.041, summation operator TEQ-PCBs 0.022 pg WHO-TEQ/g, summation operator PBDEs 23.4 pg/g whole weight, respectively) were significantly higher than those from the reference area (median: summation sigma TEQ-PCDD/Fs 0.014, summation sigma TEQ-PCBs 0.0041 pg WHO-TEQ/g, summation sigma PBDEs 16.15 pg/g, respectively) (p < 0.05). Levels of TT4 and TSH in serum in zone A were significantly lower than those in zone B (p < 0.05). A negative correlation was found between TT4 levels and body burdens of PCDD/Fs and PCBs. However, there was no significant association of concentration of PBDEs and levels of the three thyroid hormones. Our results suggest that electronic waste (e-waste) recycling contributes to high body burdens of PBDEs, PCDD/Fs, and PCBs and affects thyroid hormone homeostasis in humans. The potential health risk for neonates still needs further investigation.

Published
2010

7. Elevated Body Burdens of PBDEs, Dioxins, and PCBs on Thyroid Hormone Homeostasis at an Electronic Waste Recycling Site in China.

Author

JIANQING ZHANG, YOUSHENG JIANG, JIAN ZHOU, BIN WU, YIN LIANG, ZHAOQIONG PENG, DAOKUI FANG, BIN LIU, HAIYAN HUANG, CAI HE, CHUNLEI WANG, and FEINA LU

Subjects
*PHYSIOLOGICAL effects of polybrominated diphenyl ethers, *PHYSIOLOGICAL effects of dioxins, *PHYSIOLOGICAL effects of polychlorinated biphenyls, *THYROID hormones, *HOMEOSTASIS, *BODY burden, *ELECTRONIC waste & the environment, *WASTE recycling, SOCIAL aspects
Abstract

A cross-sectional study of 25 sample sets (each set consisted of maternal serum and cord whole blood) from 50 pregnant women in zone A (n = 25 from exposed group) and zone B (n = 25 from reference group) was conducted to examine the association between thyroid hormone (TH) levels and PBDE, PCDD/F, and PCB exposures. Thyroid hormones TT3, TT4, and TSH levels were measured in maternal serum at 16 weeks of gestation. The concentrations of PBDEs, PCDD/Fs, and PCBs were determined by isotope dilution HRGC/HRMS in cord blood samples. Body burdens of the three contaminants in cord blood in zone A (median: Σ TEQ-PCDD/Fs 0.041, Σ TEQ-PCBs 0.022 pg WHO-TEQ/g, Σ PBDEs 23.4 pg/g whole weight, respectively) were significantly higher than those from the reference area (median: Σ TEQ-PCDD/Fs 0.014, Σ TEQ-PCBs 0.0041 pg WHO-TEQ/g, Σ PBDEs 16.15 pg/g, respectively) (p < 0.05). Levels of TT4 and TSH in serum in zone A were significantly lower than those in zone B (p < 0.05). A negative correlation was found between TT4 levels and body burdens of PCDD/Fs and PCBs. However, there was no significant association of concentration of PBDEs and levels of the three thyroid hormones. Our results suggest that electronic waste (e-waste) recycling contributes to high body burdens of PBDEs, PCDD/Fs, and PCBs and affects thyroid hormone homeostasis in humans. The potential health risk for neonates still needs further investigation. [ABSTRACT FROM AUTHOR]

Published
2010
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