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Your search keyword '"Li, Yixin"' showing total 8 results
Start Over Author "Li, Yixin" Journal environmental science & technology
8 results on '"Li, Yixin"'

5. In UteroUltrafine Particulate Exposure Yields Sex- and Dose-Specific Responses to Neonatal Respiratory Syncytial Virus Infection

Author

Lau, Carmen, Behlen, Jonathan C., Myers, Alexandra, Li, Yixin, Zhao, Jiayun, Harvey, Navada, Wright, Gus, Hoffmann, Aline Rodrigues, Zhang, Renyi, and Johnson, Natalie M.

Abstract

Exposure to particulate matter (PM) is associated with lower respiratory tract infections. The role of ultrafine particles (UFPs, ≤0.1 μm) in respiratory disease is not fully elucidated, especially in models of immunologically immature populations. To characterize the effects of maternal UFP exposure on neonatal infection, we exposed time-mated C57Bl/6n mice to filtered air or UFPs at a low dose (LD, ∼55 μg/m3) and high dose (HD, ∼275 μg/m3) throughout gestation. At 5 days of age, offspring were infected with a respiratory syncytial virus (RSV) strain known to mimic infant infection or sham control. Offspring body weights were significantly reduced in response to infection in the LD RSV group, particularly females. Pulmonary gene expression analysis demonstrated significantly increased levels of oxidative stress- and inflammation-related genes in HD-exposed male offspring in sham and RSV-infected groups. In males, the highest grade of inflammation was observed in the HD RSV group, whereas in females, the LD RSV group showed the most marked inflammation. Overall, findings highlight neonatal responses are dependent on offspring sex and maternal UFP dose. Importantly, infant RSV pathology may be enhanced following even low dose UFP exposure signifying the importance of preventing maternal exposure.

Published
2022
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6. Formation and Optical Properties of Brown Carbon from Small α-Dicarbonyls and Amines

Author

Marrero-Ortiz, Wilmarie, primary, Hu, Min, additional, Du, Zhuofei, additional, Ji, Yuemeng, additional, Wang, Yujue, additional, Guo, Song, additional, Lin, Yun, additional, Gomez-Hermandez, Mario, additional, Peng, Jianfei, additional, Li, Yixin, additional, Secrest, Jeremiah, additional, Zamora, Misti L., additional, Wang, Yuan, additional, An, Taicheng, additional, and Zhang, Renyi, additional

Published
2018
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