1. Gene sequence screening for manganese poisoning-susceptible genes and analysis of gene interaction effects
- Author
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Zhen Li, Yongjian Yan, Cengceng Chen, Shuhan Guo, Yutian Tian, and Li Zhao
- Subjects
Male ,0301 basic medicine ,Health, Toxicology and Mutagenesis ,Biology ,Toxicology ,medicine.disease_cause ,Rats, Sprague-Dawley ,03 medical and health sciences ,Gene interaction ,Dopamine ,medicine ,Animals ,Genetic Predisposition to Disease ,Manganese Poisoning ,Gene ,Pharmacology ,Genetics ,Epistasis, Genetic ,General Medicine ,Corpus Striatum ,Metabolic pathway ,030104 developmental biology ,Apoptosis ,SGK1 ,Transcriptome ,Oxidative stress ,medicine.drug - Abstract
Manganese poisoning is a common occupational disease, studies have found that the susceptibility to manganese poisoning differs in individuals. We adopted genome-wide sequencing methods to screen for susceptibility genes involved in gene-mediated metabolic pathways from the perspective of manganese poisoning. We identified 18,439 genes in this study, including 14,272 known genes and 4398 new genes. We then selected 17 differential genes using p values, of which 7 genes were down-regulated and 10 genes were up-regulated. Possible interaction genes for each differential gene were selected according to the String database. Sgk1, HCRTr1, HspB1, Rem2, Oprd1, ATF5, and TRHr identified in this study may be involved in oxidative stress mechanisms, dopamine (DA) synthesis, and neuronal survival during apoptosis and may affect susceptibility to manganese poisoning.
- Published
- 2018
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