1. Clinical outcomes and programming strategies of implantable cardioverter-defibrillator devices in paediatric hypertrophic cardiomyopathy: a UK National Cohort Study
- Author
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Norah Yap, Georgia Spentzou, Sujeev Mathur, Tara Bharucha, Elspeth Brown, Dominic Hares, Gabrielle Norrish, Maria Ilina, Caroline Jones, Amos Wong, Shankar Sadagopan, Piers E.F. Daubeney, Jane Matthews, Arthur M. Yue, Zdenka Reinhardt, Jan Till, Krishnakumar Pillai, Alan Graham Stuart, Michael Bowes, Jasveer Mangat, Karen McLeod, Vinay Bhole, Katie Linter, Ella Field, Henry Chubb, Eric Rosenthal, Satish Adwani, Juan Pablo Kaski, and Orhan Uzun
- Subjects
medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Sudden cardiac death ,Cohort Studies ,Defibrillation threshold ,Clinical Research ,Risk Factors ,Interquartile range ,Physiology (medical) ,Internal medicine ,Humans ,Medicine ,Child ,Retrospective Studies ,business.industry ,Hypertrophic cardiomyopathy ,Cardiomyopathy, Hypertrophic ,Implantable cardioverter-defibrillator ,medicine.disease ,United Kingdom ,Defibrillators, Implantable ,Death, Sudden, Cardiac ,Treatment Outcome ,Cohort ,Implant ,Cardiology and Cardiovascular Medicine ,business ,Complication - Abstract
Aims Sudden cardiac death (SCD) is the most common mode of death in paediatric hypertrophic cardiomyopathy (HCM). This study describes the implant and programming strategies with clinical outcomes following implantable cardioverter-defibrillator (ICD) insertion in a well-characterized national paediatric HCM cohort. Methods and results Data from 90 patients undergoing ICD insertion at a median age 13 (±3.5) for primary (n = 67, 74%) or secondary prevention (n = 23, 26%) were collected from a retrospective, longitudinal multi-centre cohort of children ( Conclusion In a large national cohort of paediatric HCM patients with an ICD, device and programming strategies varied widely. No particular strategy was associated with inappropriate therapies, missed/delayed therapies, or lead complications.
- Published
- 2020