1. Molecular epidemiology of a familial cluster of SARS-CoV-2 infection during lockdown period in Sant Kabir Nagar, Uttar Pradesh, India
- Author
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Asif Kavathekar, Hirawati Deval, Gaurav Raj Dwivedi, Manoj Kumar, Pragya D Yadav, Niraj Kumar, S. Behera, Sanjeev Kumar, Kamlesh Kumar Sah, Anita M. Shete, Pooja Bhardwaj, Kamran Zaman, Rajni Kant, Rajeev Singh, Kaushik Kumar, Vijay Kumar, Ravi Shankar Singh, R. S. Yadav, P. N. Shankar, Girijesh Kumar Yadav, Triparna Majumdar, Savita Patil, Dimpal A Nyayanit, Priyanka Yadav, Brij Ranjan Misra, and Ashok K. Pandey
- Subjects
Uttar Pradesh ,biology ,Molecular epidemiology ,Phylogenetic tree ,SARS-CoV-2 ,Epidemiology ,Period (gene) ,Pangolin ,India ,Overcrowding ,biology.organism_classification ,Disease cluster ,Asymptomatic ,Infectious Diseases ,medicine ,Short Paper ,Familial cluster ,next-generation sequencing ,medicine.symptom ,Index case ,Demography - Abstract
We report a familial cluster of 24 individuals infected with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The index case had a travel history and spent 24 days in the house before being tested and was asymptomatic. Physical overcrowding in the house provided a favourable environment for intra-cluster infection transmission. Restriction of movement of family members due to countrywide lockdown limited the spread in community. Among the infected, only four individuals developed symptoms. The complete genome sequences of SARS-CoV-2 was retrieved using next-generation sequencing from eight clinical samples which demonstrated a 99.99% similarity with reference to Wuhan strain and the phylogenetic analysis demonstrated a distinct cluster, lying in the B.6.6 pangolin lineage.
- Published
- 2021