1. Neuron-specific enolase is increased after single seizures during inpatient video/EEG monitoring.
- Author
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Rabinowicz AL, Correale J, Boutros RB, Couldwell WT, Henderson CW, and DeGiorgio CM
- Subjects
- Adult, Blood-Brain Barrier physiology, Epilepsy diagnosis, Epilepsy, Complex Partial diagnosis, Epilepsy, Complex Partial enzymology, Epilepsy, Tonic-Clonic diagnosis, Epilepsy, Tonic-Clonic enzymology, Female, Humans, Male, Middle Aged, Monitoring, Physiologic, Psychophysiologic Disorders diagnosis, Psychophysiologic Disorders enzymology, Videotape Recording, Brain physiopathology, Electroencephalography methods, Epilepsy enzymology, Hospitalization, Phosphopyruvate Hydratase blood
- Abstract
Neuron-specific enolase (NSE) is a marker of brain injury after acute neurologic insults. We report changes in serum NSE (s-NSE) in 25 patients (15 with epilepsy and 10 patients with nonepileptic events) during continuous inpatient video/EEG monitoring. s-NSE was significantly increased as compared with baseline and normal controls after the first ictal event in the epileptic group, especially in patients with secondarily generalized tonic-clonic seizures (p = 0.01), but s-NSE was not increased in patients with nonepileptic events. These preliminary data indicate that s-NSE may be increased after complex partial seizures--and generalized tonic-clonic seizures (GTCS).
- Published
- 1996
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