7 results on '"Feng, Li"'
Search Results
2. Event-related potentials reveal visual episodic memory deficits in patients with temporal lobe epilepsy.
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Tian, Ziwei, Huang, Sha, Wen, Shirui, Zhang, Qiong, Huang, Kailing, Gui, Yawei, Hu, Bingliang, Feng, Li, and Wang, Quan
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TEMPORAL lobe epilepsy , *MEMORY disorders , *EPISODIC memory , *EVOKED potentials (Electrophysiology) , *VISUAL memory , *TEMPORAL lobe , *COGNITIVE ability - Abstract
• Temporal lobe epilepsy (TLE) patients perform worse than healthy controls in a change detection task. • The impaired episodic memory (EM) is linked to the increased P200 and decreased P300 amplitudes in TLE patients. • Only left temporal lobe epilepsy (LTLE) patients reported abnormal late posterior negativity (LPN), implying it seems to be sensitive to left temporal lobe dysfunction. • Both LTLE and right temporal lobe epilepsy (RTLE) patients reported abnormal old or new effects of FN400 and late positive potential (LPC), and reduced FN400 amplitudes, probably related to visual EM deficit. Temporal lobe epilepsy (TLE) patients usually suffer from impaired episodic memory (EM), but its underlying electrophysiologic mechanism and impacted cognitive performance are unclear. We aim to investigate the association between episodic memory reserve and physiological measures of memory workload in TLE patients using Event-related potentials (ERP). A change detection task with image stimuli assesses visual episodic memory. During the memory encoding and decoding phases, the ERP signals were analyzed from twenty-nine TLE patients (twelve with left TLE patients, seventeen with TLE), and thirty healthy controls. Given that EM is a complex process involving many fundamental cognitive processes, the amplitudes and latencies of EM-related ERP (FN400, late positive potential (LPC), and late posterior negativity (LPN)), and the ERP reflecting the fundamental processes (P100, N100, P200, and P300) were calculated. Then we used a three-by-two factorial design on the ERP metrics for interaction and main effects. The correlation analysis among Wechsler Memory Scales-Chinese Revision (WMS-RC) results, behavioral data, and the ERPs was carried out. The TLE patients performed worse in WMS-RC and the memory task. The increased P200 and decreased P300 amplitudes were observed in the TLE patients, and LPN was abnormal in only LTLE patients. For EM-related components, differences were observed in both the LTLE and RTLE patients: the lack of the FN400 effect, the lack of the reversed LPC effect, and the reduced FN400. No significant inter-group difference was detected for the latencies of all the ERPs. Additionally, there were significant correlations among WMS-RC scores, behaviors, and some ERP amplitudes. The impaired EM is linked to the increased P200 and decreased P300 amplitudes. LPN seems to be sensitive to left temporal lobe dysfunction. More importantly, the abnormal old or new effects of the FN400 and LPC, and the reduced FN400 amplitude might be associated with the visual EM deficit in the TLE patients. These findings may assist in the deep understanding of the EM disorder and the evaluation of the side effects of antiepileptic drugs. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Clinical characteristics and outcomes in pregnant women with epilepsy.
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Huang, Chun-yu, Dai, Yin-mei, Feng, Li-min, and Gao, Wan-li
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PREGNANT women , *HIGH-risk pregnancy , *MEDICAL personnel , *EPILEPSY , *LOW birth weight , *PREMATURE rupture of fetal membranes , *LENNOX-Gastaut syndrome - Abstract
Epilepsy in pregnancy can lead to substantial maternal and neonatal morbidity and mortality. Early intervention in pregnant women with epilepsy (WWE), accurate assessment of the severity of their condition, and effective treatment are required to improve maternal and neonatal prognosis. Many obstetricians lack experience in monitoring and treating pregnant WWE. The aim of this study was to describe the demographic and clinical characteristics of pregnant WWE and examine maternal and neonatal outcomes. Medical records of 75 pregnant women with a history of epilepsy who delivered at Beijing Tiantan Hospital, China between January 2006 and December 2019 were retrospectively reviewed. Pregnant women with a history of epilepsy were matched 1:2 with a control group of 150 pregnant women without epilepsy who delivered at Beijing Tiantan Hospital during the same time period. Information including type and frequency of epilepsy and seizures, maternal complications, medication, delivery mode, newborn weight, and newborn Apgar score were recorded. In subgroup analyses, pregnant WWE were stratified according to presence or absence of seizures during pregnancy and generalized seizure vs. nongeneralized seizure. The incidence of anemia, hypertensive disorder of pregnancy, premature rupture of membranes (PROM), cesarean section, and postpartum hemorrhage was significantly higher (p < 0.05), and mean newborn weight and newborn Apgar score were significantly lower (p < 0.05) in pregnant WWE compared with pregnant women without epilepsy. The incidence of premature delivery was significantly higher (p < 0.05), and mean newborn weight was significantly lower (p < 0.05) in pregnant WWE with seizures vs. without seizures. Mean newborn weight was significantly lower (p = 0.01) in pregnant WWE with nongeneralized seizures vs. generalized seizures. Pregnant WWE are at high risk of anemia, gestational hypertension, PROM, cesarean section, postpartum hemorrhage, and low newborn weight and Apgar score. Women with epilepsy who experience seizures during pregnancy are at high risk of preterm birth and having low birth weight infants. Pregnant WWE who experience nongeneralized seizures are at high risk of having low birth weight infants. These data emphasize the need to routinely monitor fetal weight on ultrasound and offer appropriate intervention. These findings highlight the need for healthcare providers to take a multidisciplinary approach to the management of pregnant WWE. Pregnant WWE are at high risk of obstetric complications. Women with epilepsy who experience seizures during pregnancy are at high risk of preterm birth and having low birth weight infants. Pregnant WWE who experience nongeneralized seizures are at high risk of having low birth weight infants. These data highlight the need for healthcare providers to take a multidisciplinary approach to the management of pregnant WWE. • Pregnant women with epilepsy (WWE) are at high risk of maternal and neonatal complications. • WWE who experience seizures during pregnancy are at high risk of preterm birth and having low birth weight infants. • Pregnant WWE who experience non-generalized seizures are at high risk of having low birth weight infants. [ABSTRACT FROM AUTHOR]
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- 2020
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4. Attitudes toward epilepsy among medical staffs in basic-level hospitals from southern China.
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Yang, Ke, Ma, Chanthia, He, Yue, Wang, Jing, Yue, Zongwei, Xiao, Bo, Liu, Ding, and Feng, Li
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ATTITUDES of medical personnel , *EPILEPSY , *SOCIAL stigma , *MENTAL health , *PEOPLE with epilepsy - Abstract
Abstract Objective The objectives of the study were to assess attitudes toward epilepsy among medical staffs from basic-level hospitals in southern China and identify significant predictive factors for future stigma reduction interventions. Methods The Public Attitudes Toward Epilepsy (PATE) scale, a two dimensional 14-item scale addressing two major domains: general domain and personal domain, was administered to 448 medical staffs from basic-level hospitals in southern China. Positively stated items in the PATE scale were reversely scored; in this case, a higher score would indicate a more negative attitude. Also, we compared the overall score and per-item scores of the medical staffs versus those of the general population reported in the previous studies using the same scale. Results The cumulative score of the medical staffs was 41.65 ± 6.99, which is significantly lower as compared with 51.38 ± 6.80 of the general population (t (645) = − 16.473, p < 0.001). The general average score (t (645) = − 16.473, p < 0.001) and the mean score in the general domain (t (645) = − 22.573, p < 0.001) of the PATE scale were both significantly lower in the medical staffs compared with the general population, whereas there was no significant difference between the two groups in the personal domain (t(645) = − 0.180, p = 0.857). Age or years in clinical practice, specialty, and title had a significant impact on both the general domain and personal domain. Residence was the only factor found affecting the medical staffs' attitudes toward epilepsy in the personal domain but not in the general domain. Conclusion Medical staffs from basic-level hospitals in southern China demonstrate significant positive attitudes toward people with epilepsy in general aspects when compared with the general population. However, they still showed negative and conservative attitudes when it comes to the personal domain. Future strategies for stigma-reducing public interventions could focus on increasing better understanding of epilepsy among medical staffs in basic-level hospitals in China. Highlights • Medical staffs' attitudes may directly affect mental health of patients with epilepsy. • Medical staffs' attitudes are more positive in the general aspects but not in the personal domain. • Age or years in clinical practice, specialty and title had a significant impact on attitudes among medical staffs. • Residence was the only factor found affecting medical staffs'attitudes toward epilepsy in the personal domain. [ABSTRACT FROM AUTHOR]
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- 2018
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5. Validation of the Chinese version of public attitudes toward epilepsy scale in Mainland China.
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Yue, Zongwei, Ma, Chanthia, Lim, Kheng-seang, Xiao, Bo, Wu, Qian, Shu, Yi, Yue, Zhiping, Wang, Yelan, and Feng, Li
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EPILEPSY , *PUBLIC health , *MEDICAL misconceptions , *EXPLORATORY factor analysis , *PSYCHOMETRICS - Abstract
Purpose Epilepsy is a significant yet seriously underappreciated public health issue in Mainland China. The stigma and discrimination toward people with epilepsy (PWE) and their families are especially severe in China based on cultural misconceptions which cause tremendous psychological, economic and social burdens. It is imperative to formulate a targeted public intervention to eliminate knowledge gaps and correct these misconceptions of epilepsy. However, to date, the essential tools that may drive such an intervention by measuring the public perspective on PWEs is lacking in China. The goal of this study is to test the reliability and validity of a Simplified Chinese version of the “Public Attitude Toward Epilepsy” scale (PATE) in Mainland China which can be used to understand the content and identify the possible sources of stigma to better inform the design and focus of future stigma reduction interventions. Methods The standard procedure of cross-cultural adaptation was used in the translation process. Subjects from different economic and social backgrounds were enrolled by convenience sampling in central China. Exploratory factor analysis and confirmatory factor analysis were used to check the underlying factor structure of the items. Furthermore, Cronbach's alpha was utilized to assess internal consistency. Results 199 respondents were included in the final analysis. Content validity of this Chinese PATE was assessed to be adequate for assessing public attitudes toward epilepsy among the mainland Chinese. Two factors were extracted from the data by exploratory factor analysis; confirmatory factor analysis further confirmed good consistency of theoretical constructs between the original Public Attitudes Toward Epilepsy scale and our Chinese PATE. Our Chinese PATE presented excellent internal consistency (α = 0.853–0.909). Conclusion This version of the Chinese PATE showed acceptable psychometric properties, indicating that it can be implemented in surveying public attitudes toward epilepsy in Mainland China. [ABSTRACT FROM AUTHOR]
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- 2017
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6. Validity and reliability of the Chinese version of the epilepsy stigma scale.
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Huang, Kailing, Wu, Yuanxia, He, Qiang, Yang, Haojun, Du, Yangsa, Xiao, Bo, and Feng, Li
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SOCIAL stigma , *CONFIRMATORY factor analysis , *EXPLORATORY factor analysis , *EPILEPSY , *CRONBACH'S alpha - Abstract
• The Chinese version of ESS was a valid tool to assess the epilepsy-related stigma. This study was conducted to test the validity and reliability of the Chinese version of the epilepsy stigma scale (ESS), which aims to better understand the stigma of patients with epilepsy (PWEs), lays the foundation for future investigation and explores appropriate strategies to mitigate PWEs' stigma in Chinese culture. The scale was translated following standard procedures. For psychometric validation, the Chinese version of the ESS was administered to 214 PWEs above the age of 16 who were diagnosed with epilepsy by two trained epileptologists and were taking anti-seizure drugs for at least a month. All of the patients were recruited from Xiangya Hospital of Central South University of China from August 2021 to September 2021. The Cronbach's alpha coefficient was 0.893 for the entire scale, 0.903 for felt stigma, and 0.688 for enacted stigma. Exploratory and confirmatory factor analyses were conducted and showed that the scale was grouped under two dimensions, and the results of confirmatory factor analysis support the structure. The Chinese version of the ESS is a valid and reliable tool to assess epilepsy-related stigma in Chinese culture. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Evaluation of anxiety, depression, and sleep quality among parents of children with epilepsy in Southern China.
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Yang, Haojun, Feng, Yanyan, Zhu, Ziqing, Qiao, Zhihua, Xiao, Bo, and Feng, Li
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ANXIETY , *CHILDHOOD epilepsy , *MENTAL depression , *CO-sleeping , *STATE-Trait Anxiety Inventory , *PARENTS - Abstract
The purpose of the study was to evaluate sleep quality in the parents of children with epilepsy (CWE) as well as their symptoms of anxiety and depression in Southern China. A structured questionnaire, comprised of The State–Trait Anxiety Inventory (STAI), Center for Epidemiologic Studies Depression Scale (CES-D), and the Pittsburgh Sleep Quality Index (PSQI), was administered to parents of CWE (n = 234) in Xiangya Hospital and parents of healthy children (n = 230) during 2019–2020. The scores (Mean ± SD) of State Anxiety Inventory (S-AI) and Trait Anxiety Inventory (T-AI) among parents of CWE were 51.850 ± 11.380 and 48.201 ± 9.526, respectively, which were significantly higher than those of control group (37.172 ± 8.047 and 37.478 ± 7.314, respectively) (p < 0.001). Compared with 10.84% in parents of healthy children, 23.51% of parents of CWE had symptoms of depression (p < 0.001). The mean score of total PSQI among parents of CWE (6.944 ± 3.814) was statistically higher than that of parents of healthy children (5.039 ± 3.390) (p < 0.001). Moreover, anxiety and depression subscores among parents of infants with epilepsy were significantly higher than in other groups. The T-AI and CES-D could explain 43.9% of the variance (R2 = 0.444, F = 92.215, p < 0.001) on the PSQI. Our study showed more severe symptoms of anxiety and depression as well as poorer sleep quality among parents of CWE, especially in the infants group. In light of this information, more attention should be paid to early identification and intervention of symptoms of anxiety and depression in susceptible parents who are the main caregivers of their CWE. • Anxiety, depression and poor sleep quality were found in parents of children with epilepsy, especially in the infant group. • Low sleep quality may precede mood disturbance or develop as a result of them. • Greater attention should be paid to the main care taker of sick child with epilepsy. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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