1. The course of tumor-related epilepsy in glioblastoma patients: A retrospective analysis.
- Author
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Stritzelberger J, Gesmann A, Fuhrmann I, Uhl M, Brandner S, Welte TM, Schembs L, Dörfler A, Coras R, Adler W, Schwab S, Putz F, Fietkau R, Distel L, and Hamer H
- Subjects
- Humans, Male, Female, Retrospective Studies, Middle Aged, Aged, Adult, Levetiracetam therapeutic use, Drug Resistant Epilepsy etiology, Drug Resistant Epilepsy epidemiology, Drug Resistant Epilepsy therapy, Seizures etiology, Glioblastoma complications, Glioblastoma therapy, Brain Neoplasms complications, Brain Neoplasms therapy, Anticonvulsants therapeutic use, Epilepsy complications, Epilepsy epidemiology, Epilepsy etiology
- Abstract
Purpose: Many patients with glioblastoma suffer from tumor-related seizures. However, there is limited data on the characteristics of tumor-related epilepsy achieving seizure freedom. The aim of this study was to characterize the course of epilepsy in patients with glioblastoma and the factors that influence it., Methods: We retrospectively analyzed the medical records of glioblastoma patients treated at the University Hospital Erlangen between 01/2006 and 01/2020., Results: In the final cohort of patients with glioblastoma (n = 520), 292 patients (56.2 %) suffered from tumor-related epilepsy (persons with epilepsy, PWE). Levetiracetam was the most commonly used first-line antiseizure medication (n = 245, 83.9 % of PWE). The onset of epilepsy was preoperative in 154/292 patients (52.7 %). 136 PWE (46.6 %) experienced only one single seizure while 27/292 PWE (9.2 %) developed drug-resistant epilepsy. Status epilepticus occurred in 48/292 patients (16.4 %). Early postoperative onset (within 30 days of surgery) of epilepsy and total gross resection (compared with debulking) were independently associated with a lower risk of further seizures. We did not detect dose-dependent pro- or antiseizure effects of radiochemotherapy., Conclusion: Tumor-related epilepsy occurred in more than 50% of our cohort, but drug-resistant epilepsy developed in less than 10% of cases. Epilepsy usually started before tumor surgery., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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