1. Neural networks underlying parietal lobe seizures: a quantified study from intracerebral recordings
- Author
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Martine Gavaret, Fabrice Wendling, Russell Hewett, Jean Régis, Fabrice Bartolomei, Patrick Chauvel, Luc Valton, Sandrine Aubert, Service de Neurophysiologie Clinique, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Epilepsies, Lesions Cerebrales et Systemes Neuraux de la Cognition, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Neurologie et Explorations Fonctionnelles du Système Nerveux [Toulouse], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Male ,Unconsciousness ,Electroencephalography ,Functional Laterality ,MESH: Magnetic Resonance Imaging ,Epilepsy ,0302 clinical medicine ,MESH: Child ,Parietal Lobe ,Epilepsy surgery ,Child ,Psychomotor Agitation ,0303 health sciences ,MESH: Parietal Lobe ,MESH: Middle Aged ,medicine.diagnostic_test ,Parietal lobe ,MESH: Psychomotor Agitation ,Middle Aged ,MESH: Seizures ,Magnetic Resonance Imaging ,Neurology ,Vestibular Diseases ,MESH: Young Adult ,MESH: Epilepsy ,Cardiology ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Female ,Psychology ,MESH: Vestibular Diseases ,Algorithms ,Adult ,medicine.medical_specialty ,Adolescent ,SEEG ,Posterior parietal cortex ,MESH: Algorithms ,Superior parietal lobule ,MESH: Unconsciousness ,Stereoelectroencephalography ,03 medical and health sciences ,Young Adult ,Seizures ,Internal medicine ,MESH: Electroencephalography ,medicine ,Humans ,Partial epilepsy ,Rapid discharge ,MESH: Functional Laterality ,030304 developmental biology ,MESH: Adolescent ,MESH: Humans ,Inferior parietal lobule ,MESH: Adult ,medicine.disease ,MESH: Male ,Epileptogenicity index ,MESH: Nerve Net ,Neurology (clinical) ,Nerve Net ,Neuroscience ,MESH: Female ,030217 neurology & neurosurgery - Abstract
International audience; In this study we have quantified the "epileptogenicity" of several brain regions in seizures originating in the posterior parietal cortex in 17 patients investigated by intracerebral recordings using stereotactic EEG (SEEG). Epileptogenicity of brain structures was quantified according to the "epileptogenicity index" (EI), a way to quantify rapid discharges at seizure onset. Seven patients had maximal epileptogenicity in the superior parietal lobule-BA area 7 (Gr1), 2 patients in the superior parietal lobule-area 5 (Gr2), 4 patients in inferior parietal lobule (Gr3) and 4 in the opercular region (Gr4). A large majority of patients (15/17 (88%)) reported to have at least one aura during the course of their disease. Somato-sensory manifestations were reported in the four groups. Vestibular disturbance was observed mainly in seizures from the superior parietal lobule (Gr1 and 2). Ipsilateral version was the most frequent objective manifestation (64%). Hyperkinetic behaviour (motor agitation) was found to be frequent, observed in 4/17 cases (23%) and observed in seizures from inferior parietal regions. In conclusion, the electrophysiological organization and the clinical manifestations of PLS are various and complex. The subjective manifestations are frequent and often suggestive, therefore must be actively sought.
- Published
- 2010