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This study investigated the various stressors encountered by the nursing profession. In particular, the following hypotheses were tested: (1) working conditions of nurses significantly affect perceived risk of injury and illness, work dissatisfaction, work satisfaction, energy state at the end of workday, the effort exerted by the registered nurse (RN), psychosomatic outcomes, and musculoskeletal symptoms (in multiple body regions); (2) both intermediate work effects (i.e., effort, perceived risk of injury/illness, work satisfaction/dissatisfaction, energy state at end of workday) and psychosomatic outcomes significantly affect musculoskeletal outcomes (in multiple body regions); (3) both working conditions and effects significantly affect musculoskeletal outcomes. In a preliminary study conducted on 34 registered nurses, results show that: (1) stressful working conditions affect musculoskeletal outcomes in multiple body regions, and (2) physical maladies such as lower back problems are not only associated with physical factors but also with a complex interaction of working conditions. Further research is warranted to obtain a better understanding of the complex interaction and the synergistic effects of the various nursing working conditions. [ABSTRACT FROM AUTHOR]