1. Restricted left atrial dilatation can visually differentiate cardiac amyloidosis from hypertrophic cardiomyopathy
- Author
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Haruhiko Higashi, Katsuji Inoue, Shinji Inaba, Yasuhisa Nakao, Masaki Kinoshita, Shigehiro Miyazaki, Toru Miyoshi, Yusuke Akazawa, Hiroshi Kawakami, Teruyoshi Uetani, Jun Aono, Takayuki Nagai, Kazuhisa Nishimura, Shuntaro Ikeda, Makoto Saito, and Osamu Yamaguchi
- Subjects
Cardiac amyloidosis ,Left atrial function ,Reservoir function ,Echocardiography ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Cardiac amyloidosis (CA) is an infiltrative myocardial disease that occasionally mimics hypertrophic cardiomyopathy (HCM). The aim of this study is to investigate the discriminatory ability of visual assessment of left atrial (LA) function between CA and HCM on echocardiography. Methods and results In total, 93 patients with cardiac magnetic resonance imaging (CMR)‐confirmed HCM and 34 with cardiac biopsy‐confirmed CA were retrospectively assessed. LA dilatation was assessed via echocardiography in an apical four‐chamber view. Visual assessment was performed to identify LA dilatation grade (preserved = 1, abnormal = 2, and restricted = 3) based on the extent of outward expansion in the LA reservoir phase. Regarding the reproducibility of visually assessing LA dilatation grade, the kappa values between intra‐ and inter‐observer measurements were 0.82 and 0.70, respectively. Of 127 participants, 57 (45%), 42 (33%), and 28 (22%) presented with LA dilatation Grades 1, 2, and 3, respectively. All 57 patients with preserved LA dilatation (Grade 1) had HCM, and 20 of 28 patients (71%) with restricted LA dilatation (Grade 3) presented with CA. Patients with CA had a higher LA dilatation grade than those with HCM (P
- Published
- 2021
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