16 results on '"Garralda E"'
Search Results
2. Challenges in oncology career: are we closing the gender gap? Results of the new ESMO Women for Oncology Committee survey
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Linardou, H., Adjei, A.A., Bajpai, J., Banerjee, S., Berghoff, A.S., Mathias, C. Cerqueira, Choo, S.P., Dent, R., Felip, E., Furness, A.J.S., Garassino, M.C., Garralda, E., Konsoulova-Kirova, A., Letsch, A., Menzies, A.M., Mukherji, D., Peters, S., Sessa, C., Tsang, J., Yang, J.C.-H., and Garrido, P.
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- 2023
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3. A first-in-human study of the anti-LAG-3 antibody favezelimab plus pembrolizumab in previously treated, advanced microsatellite stable colorectal cancer
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Garralda, E., Sukari, A., Lakhani, N.J., Patnaik, A., Lou, Y., Im, S.-A., Golan, T., Geva, R., Wermke, M., de Miguel, M., Palcza, J., Jha, S., Chaney, M., Abraham, A.K., Healy, J., and Falchook, G.S.
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- 2022
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4. Isatuximab plus atezolizumab in patients with advanced solid tumors: results from a phase I/II, open-label, multicenter study
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Simonelli, M., Garralda, E., Eskens, F., Gil-Martin, M., Yen, C.-J., Obermannova, R., Chao, Y., Lonardi, S., Melichar, B., Moreno, V., Yu, M.-L., Bongiovanni, A., Calvo, E., Rottey, S., Machiels, J.-P., Gonzalez-Martin, A., Paz-Ares, L., Chang, C.-L., Mason, W., Lin, C.-C., Reardon, D.A., Vieito, M., Santoro, A., Meng, R., Abbadessa, G., Menas, F., Lee, H., Liu, Q., Combeau, C., Ternes, N., Ziti-Ljajic, S., and Massard, C.
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- 2022
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5. Phase I, first-in-human study of MSC-1 (AZD0171), a humanized anti-leukemia inhibitory factor monoclonal antibody, for advanced solid tumors
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Borazanci, E., Schram, A.M., Garralda, E., Brana, I., Vieito Villar, M., Spreafico, A., Oliva, M., Lakhani, N.J., Hoffman, K., Hallett, R.M., Maetzel, D., Hua, F., Hilbert, J., Giblin, P., Anido, J., Kelly, A., Vickers, P.J., Wasserman, R., Seoane, J., Siu, L.L., Hyman, D.M., Hoff, D.V., and Tabernero, J.
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- 2022
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6. Safety and preliminary activity results of the GATTO study, a phase Ib study combining the anti-TA-MUC1 antibody gatipotuzumab with the anti-EGFR tomuzotuximab in patients with refractory solid tumors
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Ochsenreither, S., Fiedler, W.M., Conte, G.D., Macchini, M., Matos, I., Habel, B., Ahrens-Fath, I., Raspagliesi, F., Lorusso, D., Keilholz, U., Rolling, C., Kebenko, M., Klinghammer, K.F., Saavedra, O., Baumeister, H., Zurlo, A., and Garralda, E.
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- 2022
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7. Female leadership in oncology—has progress stalled? Data from the ESMO W4O authorship and monitoring studies
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Berghoff, A.S., Sessa, C., Yang, J.C.-H., Tsourti, Z., Tsang, J., Tabernero, J., Peters, S., Linardou, H., Letsch, A., Haanen, J., Garralda, E., Garassino, M.C., Furness, A.J.S., Felip, E., Dimopoulou, G., Dafni, U., Choo, S.P., Banerjee, S., Bajpai, J., Adjei, A.A., and Garrido, P.
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- 2021
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8. Has COVID-19 had a greater impact on female than male oncologists? Results of the ESMO Women for Oncology (W4O) Survey
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Garrido, P., Adjei, A.A., Bajpai, J., Banerjee, S., Berghoff, A.S., Choo, S.P., Felip, E., Furness, A.J.S., Garralda, E., Haanen, J., Letsch, A., Linardou, H., Peters, S., Sessa, C., Tabernero, J., Tsang, J., Yang, J.C-.H., and Garassino, M.C.
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- 2021
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9. 29O Clinical characterization of long-term survivors in phase I clinical trials
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Mirallas, O., primary, Rossi, A., additional, Fernández, E.M., additional, Garcia-Galea, E., additional, Cano, K.S. Vega, additional, Moya, J. Ginard, additional, Calvo, A. Hernando, additional, Pretelli, G., additional, Bardaji, M.J. Lostes, additional, Oberoi, A., additional, Galvao, V., additional, Laimito, K.I. Rojas, additional, Morillo, B. Ortega, additional, Casal, G. Alonso, additional, Izquierdo, S. Aguilar, additional, Braña, I., additional, Dienstmann, R., additional, Villar, M. Vieito, additional, and Garralda, E., additional
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- 2024
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10. 93P Evolving landscape of targeted therapies (TT) in early phase clinical trials (EPCT): The RESISTANCE project (360R)
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Rossi, A., primary, Braña, I., additional, Villar, M. Vieito, additional, Casal, G. Alonso, additional, Santa Gadea, O. Saavedra, additional, Mirallas, O., additional, Bardaji, M.J. Lostes, additional, Galvao, V., additional, Laimito, K.I. Rojas, additional, Oberoi, A., additional, Pretelli, G., additional, Morillo, B. Ortega, additional, Sanz, M., additional, Izquierdo, S. Aguilar, additional, Raskina, K., additional, Dienstmann, R., additional, Vivancos, A., additional, Tabernero, J., additional, Garralda, E., additional, and Calvo, A. Hernando, additional
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- 2024
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11. 99P Molecular correlates and treatment outcomes of patients with brain metastasis included in early phase trials: A single-center retrospective analysis
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Pretelli, G., primary, Laimito, K.I. Rojas, additional, Casal, G. Alonso, additional, Bardaji, M.J. Lostes, additional, Calvo, A. Hernando, additional, Galvao, V., additional, Oberoi, A., additional, Morillo, B. Ortega, additional, Mirallas, O., additional, Santa Gadea, O. Saavedra, additional, Manich, C. Saura, additional, Fernandez, M.E. Elez, additional, Ortiz, C., additional, Couselo, E. Muñoz, additional, Braña, I., additional, Galceran, J.C., additional, Felip, E., additional, Garralda, E., additional, and Villar, M. Vieito, additional
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- 2024
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12. Safety and preliminary activity results of the GATTO study, a phase Ib study combining the anti-TA-MUC1 antibody gatipotuzumab with the anti-EGFR tomuzotuximab in patients with refractory solid tumors
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S. Ochsenreither, W.M. Fiedler, G.D. Conte, M. Macchini, I. Matos, B. Habel, I. Ahrens-Fath, F. Raspagliesi, D. Lorusso, U. Keilholz, C. Rolling, M. Kebenko, K.F. Klinghammer, O. Saavedra, H. Baumeister, A. Zurlo, E. Garralda, Institut Català de la Salut, [Ochsenreither S] Charité Comprehensive Cancer Center, Berlin, Germany. Charité, Department of Hematology, Oncology and Tumor Immunology, Berlin, Germany. German Cancer Consortium (DKTK), Berlin, Germany. [Fiedler WM] University Medical Center Hamburg-Eppendorf, Hubertus-Wald University Cancer Center, Hamburg, Germany. [Conte GD, Macchini M] Fondazione IRCCS San Raffaele Hospital, Milan, Italy. [Matos I, Saavedra O, Garralda E] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Habel B] Glycotope GmbH, Berlin, Germany, and Vall d'Hebron Barcelona Hospital Campus
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Cancer Research ,Lung Neoplasms ,Càncer - Tractament ,Mucin-1 ,Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] ,Antibodies, Monoclonal ,Antineoplastic Agents ,Other subheadings::Other subheadings::/drug therapy [Other subheadings] ,Otros calificadores::Otros calificadores::/efectos adversos [Otros calificadores] ,Anticossos monoclonals - Efectes secundaris ,Neoplasms [DISEASES] ,neoplasias [ENFERMEDADES] ,ErbB Receptors ,Oncology ,Carcinoma, Non-Small-Cell Lung ,Other subheadings::Other subheadings::/adverse effects [Other subheadings] ,Humans ,Erratum ,Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal [CHEMICALS AND DRUGS] ,Colorectal Neoplasms ,aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales [COMPUESTOS QUÍMICOS Y DROGAS] - Abstract
Colorectal cancer; Lung cancer; Monoclonal antibody Cáncer colorrectal; Cáncer de pulmón; Anticuerpo monoclonal Càncer colorectal; Càncer de pulmó; Anticòs monoclonal Background The phase I GATTO study (NCT03360734) explored the feasibility, tolerability and preliminary activity of combining gatipotuzumab, a novel humanized monoclonal antibody binding to the tumor-associated epitope of mucin 1 (TA-MUC1) and an anti-epidermal growth factor receptor (anti-EGFR) antibody in refractory solid tumors. Patients and methods Initially the study enrolled primary phase (PP) patients with EGFR-positive metastatic solid tumors, for whom no standard treatment was available. Patients received gatipotuzumab administered at 1400 mg every 2 weeks, 6 weeks after the start of the glyco-optimized anti-EGFR antibody tomuzotuximab at 1200 mg every 2 weeks. As this regimen was proven safe, enrollment continued in an expansion phase (EP) of patients with refractory metastatic colorectal cancer, non-small-cell lung cancer, head and neck cancer and breast cancer. Tomuzotuximab and gatipotuzumab were given at the same doses and gatipotuzumab treatment started 1 week after the first dose of the anti-EGFR antibody. Additionally, investigators could use a commercial anti-EGFR antibody in place of tomuzotuximab. Results A total of 52 patients were enrolled, 20 in the PP and 32 in the EP. The combined treatment was well tolerated and no dose-limiting toxicity was observed in the whole study, nor related serious adverse event or death. Preliminary activity of the combination was observed, with one and four RECIST partial responses in the PP and EP, all in colorectal cancer patients. The trial was accompanied by a comprehensive translational research program for identification of biomarkers, including soluble TA-MUC1 (sTA-MUC1) in serum. In the EP, patients with baseline sTA-MUC1 levels above the median appeared to have improved progression-free survival and overall survival. Conclusions Combination of a TA-MUC1-targeting antibody and an EGFR-targeting antibody is safe and feasible. Interesting antitumor activity was observed in heavily pretreated patients. Future studies should test this combination together with chemotherapy and explore the potential of sTA-MUC1 as a companion biomarker for further development of the combination. This work was supported by Glycotope GmbH (no grant number).
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- 2021
13. A first-in-human study of the anti-LAG-3 antibody favezelimab plus pembrolizumab in previously treated, advanced microsatellite stable colorectal cancer
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E, Garralda, A, Sukari, N J, Lakhani, A, Patnaik, Y, Lou, S-A, Im, T, Golan, R, Geva, M, Wermke, M, de Miguel, J, Palcza, S, Jha, M, Chaney, A K, Abraham, J, Healy, G S, Falchook, Institut Català de la Salut, [Garralda E] Research Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Sukari A] Medical Oncology, Karmanos Cancer Institute, Detroit, USA. [Lakhani NJ] Clinical Research, START Midwest, Grand Rapids, USA. [Patnaik A] Clinical Research, START San Antonio, USA. [Lou Y] Oncology, Mayo Clinic, Jacksonville, USA. [Im SA] Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea, and Vall d'Hebron Barcelona Hospital Campus
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Cancer Research ,Otros calificadores::/uso terapéutico [Otros calificadores] ,Immunoteràpia ,Medicaments antineoplàstics - Ús terapèutic ,Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] ,Other subheadings::Other subheadings::/drug therapy [Other subheadings] ,neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales [ENFERMEDADES] ,Còlon - Càncer - Tractament ,Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [DISEASES] ,Oncology ,Recte - Càncer - Tractament ,Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents::Antineoplastic Agents, Immunological [CHEMICALS AND DRUGS] ,Other subheadings::/therapeutic use [Other subheadings] ,acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos::inmunoterapia antineoplásica [COMPUESTOS QUÍMICOS Y DROGAS] - Abstract
Advanced; Colorectal cancer Avanzado; Cáncer colorrectal Avançat; Càncer colorrectal Background Treatment options are limited for participants with microsatellite stable (MSS) metastatic colorectal cancer (mCRC) that progressed after two or more prior therapies. Studies have shown that blockade of both lymphocyte-activation gene 3 (LAG-3) and programmed cell death protein 1 (PD-1) can improve antitumor activity. Here, we evaluate the antitumor activity of the LAG-3 antibody favezelimab alone or in combination with pembrolizumab in participants with MSS mCRC. Patients and methods Eligible participants with MSS PD-1/programmed death-ligand 1 (PD-L1) treatment-naive mCRC that progressed on two or more prior therapies received 800 mg favezelimab, 800 mg favezelimab plus 200 mg pembrolizumab, or 800 mg favezelimab/200 mg pembrolizumab co-formulation, every 3 weeks. The primary endpoint was safety, the secondary endpoint was objective response rate (ORR), and exploratory endpoints included duration of response, progression-free survival (PFS), and overall survival (OS). Results At the data cut-off date of 23 October 2020, a total of 20 participants received favezelimab alone, 89 received favezelimab plus pembrolizumab (including as favezelimab/pembrolizumab co-formulation); 48 had PD-L1 combined positive score (CPS) ≥1 tumors. At this interim analysis median follow-up was 5.8 months with favezelimab and 6.2 with favezelimab plus pembrolizumab. Treatment-related adverse events (TRAEs) were 65% with favezelimab and 65.2% with favezelimab plus pembrolizumab. Grade ≥3 TRAEs were 15% with favezelimab and 20% with favezelimab plus pembrolizumab. No grade 5 TRAEs occurred. Common TRAEs (≥15%) included fatigue (20.0%), nausea (15.0%) with favezelimab, and fatigue (16.9%) with favezelimab plus pembrolizumab. Confirmed ORR was 6.3% with favezelimab plus pembrolizumab, with median duration of response of 10.6 months (range 5.6-12.7 months), median OS of 8.3 months (95% confidence interval 5.5-12.9 months), and median PFS of 2.1 months (1.9-2.2 months). In an exploratory analysis of PD-L1 CPS ≥1 tumors, the confirmed ORR was 11.1%, median OS was 12.7 months (4.5 to not reached), and median PFS was 2.2 months (1.8-4.2 months) with favezelimab plus pembrolizumab. Conclusions Favezelimab with or without pembrolizumab had a manageable safety profile, with no treatment-related deaths. Promising antitumor activity was observed with combination therapy, particularly in participants with PD-L1 CPS ≥1 tumors. This work was supported by Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA (no grant number).
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- 2022
14. Has COVID-19 had a greater impact on female than male oncologists? Results of the ESMO Women for Oncology (W4O) Survey
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Susana Banerjee, J. Tsang, Marina Chiara Garassino, S.P. Choo, C. Sessa, E. Garralda, Enriqueta Felip, J.C.-H. Yang, Solange Peters, Araba A. Adjei, J.B.A.G. Haanen, J. Bajpai, A.S. Berghoff, A. Letsch, Andrew Furness, J. Tabernero, H. Linardou, Pilar Garrido, Institut Català de la Salut, [Garrido P] Universidad de Alcalá, Medical Oncology Department, IRYCIS, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Adjei AA] Mayo Clinic, Rochester, USA. [Bajpai J] Tata Memorial Centre, Mumbai, India. [Banerjee S] The Royal Marsden NHS Foundation Trust, Institute of Cancer Research, London, UK. [Berghoff AS] Division of Oncology, Department of Medicine 1, Medical University of Vienna, Vienna, Austria. [Choo SP] Curie Oncology Singapore, National Cancer Centre Singapore, Singapore. [Felip E] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Thoracic Oncology and H&N Cancer Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. UVic-UCC, Barcelona, Spain. [Garralda E] Early Drug Development Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Tabernero J] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. UVic-UCC, Barcelona, Spain, and Vall d'Hebron Barcelona Hospital Campus
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Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Adult ,Male ,Oncology ,Cancer Research ,medicine.medical_specialty ,Oncologia ,Coronavirus disease 2019 (COVID-19) ,media_common.quotation_subject ,Personal life ,Qüestionaris ,COVID-19 ,gender ,inequalities ,oncology ,survey ,woman ,Medical Oncology ,Young Adult ,Promotion (rank) ,Persons::Occupational Groups::Health Personnel::Physicians::Oncologists [NAMED GROUPS] ,Surveys and Questionnaires ,Internal medicine ,Pandemic ,virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES] ,Pandèmia de COVID-19, 2020 ,Humans ,Medicine ,Pandemics ,Original Research ,media_common ,Oncologists ,Personal care ,SARS-CoV-2 ,business.industry ,Professional career ,Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES] ,técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Middle Aged ,Family life ,personas::grupos profesionales::personal sanitario::médicos::oncólogos [DENOMINACIONES DE GRUPOS] ,Communicable Disease Control ,Female ,Gender gap ,business - Abstract
Background European Society for Medical Oncology Women for Oncology (ESMO W4O) research has previously shown under-representation of female oncologists in leadership roles. As early reports suggested disproportionate effects of the COVID-19 pandemic on women, the ESMO W4O Committee initiated a study on the impact of the pandemic on the lives of female and male oncologists. Methods A questionnaire was sent to ESMO members and put on the ESMO website between 8 June 2020 and 2 July 2020. Questions focused on the working (hospital tasks, laboratory tasks, science) and home (household management, childcare, parent care, personal care) lives of oncologists during and after COVID-19-related lockdowns. Results Of 649 respondents, 541 completed the questionnaire. Of these, 58% reported that COVID-19 had affected their professional career, 83% of whom said this was in a negative way (85% of women versus 76% of men). Approximately 86% reported that COVID-19 had changed their personal life and 82% their family life. Women were again significantly more affected than men: personal life (89% versus 78%; P = 0.001); family life (84% versus 77%; P = 0.037). During lockdowns, women reported increased time spent on hospital and laboratory tasks compared with men (53% versus 46% and 33% versus 26%, respectively) and a significantly higher proportion of women than men spent less time on science (39% versus 25%) and personal care (58% versus 39%). After confinement, this trend remained for science (42% versus 23%) and personal care (55% versus 36%). Conclusions The COVID-19 pandemic has adversely affected the professional and home lives of oncologists, especially women. Reduced research time for female oncologists may have long-lasting career consequences, especially for those at key stages in their career. The gender gap for promotion to leadership positions may widen further as a result of the pandemic., Highlights • Female oncologists were significantly more affected than men by COVID-19 in multiple aspects of their working and home life. • Reduced time available to female oncologists for research activities may have long-lasting career consequences. • The gender gap for promotion to leadership positions may widen further as a result of the pandemic. • Greater awareness is needed about gender inequalities in career development in oncology, especially after the pandemic. • Gender transformative policies and strategies are needed due to the impact of COVID-19 and other causes of inequalities.
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- 2021
15. Report on the status of women occupying leadership roles in oncology.
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Hofstädter-Thalmann E, Dafni U, Allen T, Arnold D, Banerjee S, Curigliano G M.D, Garralda E, Garassino MC, Haanen J, Robert C, Sessa C, Tsourti Z, Zygoura P, and Peters S
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Background: While the global workforce is approaching gender parity, women occupy a small number of management level positions across most professions, including healthcare. Although the inclusion of women into the membership of many oncology societies has increased, the under-representation of women in leadership roles within international and national oncology societies remains relatively consistent. Moreover, the exact status of women participating as board members or presidents of oncology societies or as speakers at oncology congresses was undocumented to date., Methods: The database used in this analysis was derived from data collection performed by the European Society for Medical Oncology for the years 2015-2016 and data analyses performed using the Statistical Analysis Software V.9.3 and R language for statistical computing V.3.4.0 by Frontier Science Foundation-Hellas. The literature search was performed by the authors., Results: We report the presence of a gender gap within oncology. Results regarding the under-representation of women occupying leadership roles in oncology show female participation as members of the board or presidents of national and international oncology societies and as invited speakers at oncology congresses remains below 50% in the majority of societies included in this analysis. Women in leadership positions of societies was associated with a higher percentage of female invited speakers at these societies' congresses (p=0.006)., Conclusion: The full contribution that can be attained from using the potential of women in leadership roles is currently under-realised. Examples of how gender and minority participation in organisations improves outcomes and creativity are provided from science, clinical practice and industry that show outcomes are greatly improved by collective participation of both men and women. Although there are programmes in place in many oncology organisations to improve this disparity, the gender gap is still there. Ongoing discussion may help to create more awareness in the effort to accelerate the advancement of women within oncology., Competing Interests: Competing interests: EH-T is an employee of Janssen, the Pharmaceutical Company of Johnson & Johnson Europe, and a shareholder of Johnson & Johnson. DA has received research funding and/or honoraria from Roche, Merck Serono, Bayer Healthcare, Servier, BTG, Terumo, Sanofi Oncology, Eli Lilly and has participated in non-financial roles as ECCO Executive Board member, ECCO Oncopolicy Group member, EORTC Task Force member (Gastrointestinal cancers)—Global PI function with MOLOGEN, IMPALA trial (MGN 1703 as investigative agent). GC has received research funding and/or honoraria from Roche, Novartis, Pfizer and has participated in non-financial roles as a member of Steering Committee in clinical trials, member of data safety monitoring committee for clinical trials. EG has participated as Advisor for Roche, Neomed Therapeutics and Ellypses Pharma. MCG has received research funding and/or honoraria from MSD, BMS, Roche Astra Zeneca, Takeda and Eli Lilly. CR has been a consultant for BMS, Roche, Novartis, Pierre Fabre, MDS and Amgen. CS is a Scientific Consultant for SAKK (Swiss group for cancer research treatment) and has participated in non-financial roles as the ESGO Vice President, Principal Investigator for the Icon 8B Study, EUPATI Switzerland. SP has received research funding and/or honoraria from Genentech/Roche, Pfizer, Eli Lilly, MSD, Merck Serono, BMS, Novartis, Astra Zeneca, Boehringer Ingelheim, Amgen, Clovis, Regeneron, Janssen, Takeda and has participated in non-financial roles on the IASLC Board of Directors 2014–2017, SAKK lung group Vice-president, SAMO Vice-president, Froome Past President (2011–2017), ETOP Foundation Council/Scientific coordinator, ESMO president elect 2010–2021, PI ALEX trial, Genentech Steering committee, PI academic trials ETOP, EORTC/SAKK, FMH, IASLC, AACR.
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- 2018
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16. Gender-related challenges facing oncologists: the results of the ESMO Women for Oncology Committee survey.
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Banerjee S, Dafni U, Allen T, Arnold D, Curigliano G M.D, Garralda E, Garassino MC, Haanen J, Hofstädter-Thalmann E, Robert C, Sessa C, Tsourti Z, Zygoura P, and Peters S
- Abstract
Background: Although women account for a growing proportion of the oncology workforce, there is evidence they are under-represented in leadership roles. To gain further insights into this issue and extend understanding of gender challenges, the European Society for Medical Oncology Women for Oncology (W4O) Committee undertook a survey of female and male oncologists in 2016., Design: The 2016 W4O questionnaire included questions on (1) Demographics and professional environment, (2) Gender impact on career development, (3) Challenges for career progression and inappropriate behaviour experienced in the workplace, (4) Barriers for gender parity and (5) The gender gap. Between July and September 2016, the online survey was available to male and female clinical and academic oncology healthcare professionals in the EU and internationally., Results: Responses were analysed from 462 oncologists, of whom 76.7 % were women. Of female respondents, 45.5 % had a managerial or leadership role, compared with 65 % of male respondents (p<0.001). Men were more likely to have leadership roles, even in clinical teams with more women than men. Women respondents were more likely to consider their gender had a major impact on their career than men: 35.9 % vs 20.9 % (p<0.001). The biggest challenge to career progression for women was work and family balance (64.2%). Of female respondents, 14.4 % believed there had been significant or major progress in closing the gender pay gap compared with 39.3 % of men (p<0.001). Of female participants, 37.7 % reported they had encountered unwanted sexual comments by a superior or colleague., Conclusions: New initiatives are needed to address under-representation of women oncologists in leadership roles, including greater and concrete promotion of work-life balance, development and leadership training for women, and more support for flexible working. The fact that over a third of women in the survey had encountered unwanted sexual comments at work is of great concern and must be urgently addressed., Competing Interests: Competing interests: DA has received research funding and/or honoraria from Roche, Merck Serono, Bayer Healthcare, Servier, BTG, Terumo, Sanofi Oncology, Eli Lilly and has participated in non-financial roles as ECCO Executive Board member, ECCO Oncopolicy Group member, EORTC Task Force member (Gastrointestinal cancers)—Global PI function with MOLOGEN, IMPALA trial (MGN 1703 as investigative agent). GC has received research funding and/or honoraria from Roche, Novartis, Pfizer and has participated in non-financial roles as a member of Steering Committee in clinical trials, member of data safety monitoring committee for clinical trials. MCG has received research funding and/or honoraria from MSD, BMS, Roche Astra Zeneca, Takeda and Eli Lilly. EG has participated as Advisor for Roche, Neomed Therapeutics and Ellypses Pharma. EH-T is an employee of Janssen, the Pharmaceutical Company of Johnson & Johnson Europe, and a shareholder of Johnson & Johnson. CR has been a consultant for BMS, Riche, Novartis, Pierre Fabre, MDS and Amgen. CS is a Scientific Consultant for SAKK (Swiss group for cancer research treatment) and has participated in non-financial roles as the ESGO Vice President, Principal Investigator for the Icon 8B Study, EUPATI Switzerland. SP has received research funding and/or honoraria from Genentech/Roche, Pfizer, Eli Lilly, MSD, Merck Serono, BMS, Novartis, Astra Zeneca, Boehringer Ingelheim, Amgen, Clovis, Regeneron, Janssen, Takeda and has participated in non-financial roles on the IASLC Board of Directors 2014–2017, SAKK lung group Vice-president, SAMO Vice-president, Froome Past President (2011–2017), ETOP Foundation Council/Scientific coordinator, ESMO president elect 2010–2021, PI ALEX trial, Genentech Steering committee, PI academic trials ETOP, EORTC/SAKK, FMH, IASLC, AACR.
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- 2018
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