Search

Your search keyword '"Jennifer C. Paterson"' showing total 2 results
Start Over Author "Jennifer C. Paterson" Journal eupa open proteomics
2 results on '"Jennifer C. Paterson"'

1. Distribution analysis of the putative cancer marker S100A4 across invasive squamous cell carcinoma penile tissue

Author

Brian Flatley, Chris Quaye, Elizabeth Johnson, Alex Freeman, Asif Muneer, Suks Minhas, Jennifer C. Paterson, Fawaz Musa, Peter Malone, and Rainer Cramer

Subjects
MALDI MS imaging, Penile cancer, S100A4, Biomarker discovery, Genetics, QH426-470
Abstract

MS-based proteomic methods were utilised for the first time in the discovery of novel penile cancer biomarkers. MALDI MS imaging was used to obtain the in situ biomolecular MS profile of squamous cell carcinoma of the penis which was then compared to benign epithelial MS profiles. Spectra from cancerous and benign tissue areas were examined to identify MS peaks that best distinguished normal epithelial cells from invasive squamous epithelial cells, providing crucial evidence to suggest S100A4 to be differentially expressed. Verification by immunohistochemistry resulted in positive staining for S100A4 in a sub-population of invasive but not benign epithelial cells.

Published
2015
Full Text
View/download PDF

2. Distribution analysis of the putative cancer marker S100A4 across invasive squamous cell carcinoma penile tissue

Author

Rainer Cramer, Alex Freeman, Asif Muneer, Elizabeth Johnson, Jennifer C. Paterson, Suks Minhas, Fawaz Musa, Chris Quaye, Peter Malone, and Brian Flatley

Subjects
In situ, Pathology, medicine.medical_specialty, lcsh:QH426-470, Anatomy, Biology, medicine.disease, Penile cancer, Biochemistry, lcsh:Genetics, medicine.anatomical_structure, medicine, Distribution (pharmacology), Immunohistochemistry, MALDI MS imaging, S100A4, Basal cell, Biomarker discovery, Penis, Cancer marker
Abstract

MS-based proteomic methods were utilised for the first time in the discovery of novel penile cancer biomarkers. MALDI MS imaging was used to obtain the in situ biomolecular MS profile of squamous cell carcinoma of the penis which was then compared to benign epithelial MS profiles. Spectra from cancerous and benign tissue areas were examined to identify MS peaks that best distinguished normal epithelial cells from invasive squamous epithelial cells, providing crucial evidence to suggest S100A4 to be differentially expressed. Verification by immunohistochemistry resulted in positive staining for S100A4 in a sub-population of invasive but not benign epithelial cells.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results