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Aim:This study aimed to evaluate the indications for intravenous recombinant tissue plasminogen activator (IV r-tPA) and/or mechanical thrombectomy in patients with acute stroke and the research intended to determine why these treatments were not applied in some cases.Materials and Methods:This study included 300 stroke patients treated between January 2018 and June 2019 for whom the data were accessible. The patients with acute stroke were retrospectively examined with regards to demographic and clinical information.Results:Of the 300 patients, 142 (47%) were females and 158 (52%) were males and 214 patients (71%) were admitted to the hospital within the first 4.5 hours. The mean age of the patients was 68.11±13.15 years (34-94 years). Moreover, 58 (19%) patients did not receive IV r-tPA and/ or undergo mechanical thrombectomy owing to contraindications.Conclusion:In this study, we determined that the most common reason for not applying IV r-tPA and/or mechanical thrombectomy was the inability of some patients to reach the hospital within the treatment window. Multi-centre studies are needed to investigate the various factors contributing to the delay in accessing treatment for patients with acute ischaemic stroke. Addressing these issues may increase the proportion of patients receiving thrombolytic therapy and/or undergoing mechanical thrombectomy.