1. Comparison of different priming techniques on the onset time and intubating conditions of rocuronium
- Author
-
Belgin Yavascaoglu, V. Cebelli, Oya Kutlay, N. Uçkunkaya, N. Kelebek, Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji & Reanimasyon Anabilim Dalı., Yavaşçaoğlu, Belgin, Cebelli, V, Kelebek, Nermin, Uçkunkaya, Nesimi, Kutlay, Oya, AAI-7914-2021, and AAG-9356-2021
- Subjects
Aspiration pneumonia ,Male ,Time Factors ,medicine.medical_treatment ,Androstane derivative ,Induction ,Anesthesiology ,Controlled clinical trial ,Intubation ,Anesthesia ,Hypoxia ,Rocuronium Bromide ,Middle Aged ,Endotracheal intubation ,Mivacurium ,Clinical trial ,Randomized controlled trial ,Elective Surgical Procedures ,Surgical procedures, elective ,Atracurium ,Neuromuscular Blockade ,Female ,Rocuronium ,Neuromuscular non-aepolarizing agents ,Priming (psychology) ,Human ,medicine.drug ,Adult ,medicine.medical_specialty ,Adolescent ,Major clinical study ,Placebo ,Article ,Time ,Dose response ,Vecuronium ,Principle ,medicine ,Intubation, Intratracheal ,Humans ,Neuromuscular depolarizing agent ,Androstanols ,Org-9426 ,Elective surgery ,Aged ,Analysis of Variance ,Anesthesiological techniques ,Dose-Response Relationship, Drug ,business.industry ,Tracheal intubation ,Surgery ,Anesthesiology and Pain Medicine ,Neuromuscular blocking agents ,Neuromuscular Depolarizing Agents ,Neuromuscular blocking ,Comparative study ,Anesthesia induction ,business ,Controlled study ,Suxamethonium ,Neuromuscular Blocking Agents - Abstract
Background and objective: The aim was to compare the effects of two different priming doses and priming intervals with the standard intubating dose of rocuronium on the onset time and intubation conditions. Methods: After induction of anaesthesia, 75 patients were randomly assigned to one of five groups. Patients in Group I received a priming dose of rocuronium 0.06 mg kg(-1) followed 2 min later by rocuronium 0.54 mg kg(-1), Group 2 received a priming dose of 0.10 mg kg(-1) followed 2 min later by a rocuronium injection of 0.50 mg kg(-1). Group 3 was given a priming dose of 0.06 mg kg(-1) followed 3 min later by administration 0.54 mg kg(-1) where Group 4 received a priming dose of 0.10 mg kg(-1) followed 3 min later by injection of 0.50 mg kg(-1). Group 5 received a placebo injection followed 3 min later by rocuronium 0.60 mg kg(-1). Results: Priming with a 3 min priming interval shortened the onset time of rocuronium irrespective of the dosage of (P < 0.001). Clinical duration of action was significantly longer after priming in Group 4 than in Group 5. Clinically acceptable intubation conditions were obtained in all patients. Conclusions: Priming with a 3 min priming interval was effective when rapid tracheal intubation with rocuronium was necessary. However, priming with rocuronium should be used carefully with special attention given to the possibility of hypoxia and aspiration of gastric contents in awake patients.
- Published
- 2002