1. Analogy between fibrinogen and casein.
- Author
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Jollès, Pierre, Lévy-toledano, Sylviane, Fiat, Anne-Marie, Soria, Claudine, Gillessen, Dieter, Thomaidis, Annick, Dunn, Fred W., and Caen, Jacques P.
- Subjects
FIBRINOGEN ,CASEINS ,PEPTIDES ,BLOOD coagulation ,MILK ,PROTEIN precursors - Abstract
A large number of similarities have previously been noted between the blood and milk clotting phenomena [Jollès, P. (1975) Mol. Cel. Biochem. 7, 73-85; Jollès, P. & Henschen, A. (1982) Trends Biochem. Sci. 7, 325-328]: some analogous features have also been found between fibrinogen and κ-casein. In this connection, the effect of a natural and a synthetic peptide derived from κ-casein on platelet function was studied: the undecapeptide Met-Ala-Ile-Pro-Pro-Lys-Lys-Asn-Gln-Asp-Lys (residues 106 → 116 of cow κ-casein) inhibited both aggregation of ADP-treated platelets and binding of
125 I-fibrinogen to ADP-treated platelets: its behaviour was similar to that of the structurally related C-terminal dodecapeptide of human fibrinogen y-chain. [ABSTRACT FROM AUTHOR]- Published
- 1986
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