1. 580 Assessment of interleukin-2-induced cardiovascular toxicity by cardiac echocardiography
- Author
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E. Rossetti, Giovanni Citterio, Claudio Rugarli, Ugo Scaglietti, G. Di Lucca, S.E. Chierchia, Moreno Tresoldi, and Gabriele Fragasso
- Subjects
Cardiovascular toxicity ,Interleukin 2 ,Cancer Research ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Melanoma ,Treatment withdrawal ,Physical examination ,medicine.disease ,Discontinuation ,Oncology ,Internal medicine ,Anesthesia ,Toxicity ,medicine ,Cardiology ,Cell cancer ,business ,medicine.drug - Abstract
Cardiovascular toxicity related to i. v. administration of Interleukin2 (IL-2) is the main cause of treatment withdrawal and it is unpredictable on the base of standard pre-treatment evaluations including history, physical examination and EKG. We performed this study to investigate the value of Cardiac Ultra Sono Scan (CUSS) in the detection and prediction of such toxicity. The study included 19 patients (15 males, 4 females, median age: 51, tumor type: 10 advanced renal cell cancer, 9 malignant melanoma) scheduled to receive multiple cycles of IL-2 by continuous i. v. infusion at the dose of 18 MIU/m 2 /day for 96 hours. Data were recorded from 31 IL-2 infusions: a marked impairment of diastolic function was observed in all cases, but in a subset of cycles (12/31) this function was already impaired at the pre-treatment determination, and this was significantly correlated with the onset of major cardiovascular side-effects conditioning treatment discontinuation ( P P
- Published
- 1995
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