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Start Over Author "David Sacerdoti" Journal european journal of clinical investigation
2 results on '"David Sacerdoti"'

1. Gemfibrozil improves insulin sensitivity and flow-mediated vasodilatation in type 2 diabetic patients

Author

S Del Prato, Lucia Gottardo, Angelo Avogaro, A. Favaro, Enzo Manzato, S. de Kreutzenberg, Sabina Zambon, M. Miola, Giovanni Pacini, David Sacerdoti, Antonio Tiengo, and T. Piliego

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Cholesterol, business.industry, Insulin, medicine.medical_treatment, Clinical Biochemistry, General Medicine, medicine.disease, Biochemistry, chemistry.chemical_compound, Endocrinology, Insulin resistance, chemistry, Diabetes mellitus, Internal medicine, medicine, Gemfibrozil, lipids (amino acids, peptides, and proteins), Metabolic syndrome, Lipid profile, business, medicine.drug, Lipoprotein
Abstract

Background Endothelial dysfunction is an early feature of atherosclerosis. The relationship between insulin action and hypertriglyceridaemia on endothelial function is still debated. Materials and Methods This study was designed to determine the effect of a 3 month treatment with Gemfibrozil (GF) on flow-mediated vasodilatation and insulin sensitivity. Ten type 2 diabetic patients were randomised in crossover, double blind fashion, either to GF, 600 mg b.i.d. or placebo, for 12 weeks. Lipid profile, low-density lipoprotein (LDL) distribution and flotation properties, insulin action and flow-mediated vasodilatation (FMD) by brachial artery ultrasound, were assessed. Results GF decreased serum triglyceride (TG) concentration with an absolute difference of 1·79 ± 1·28 mmol Lāˆ’1 (P

Published
2001
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2. Tubular site of renal sodium retention in ascitic liver cirrhosis evaluated by lithium clearance

Author

Carlo Merkel, David Sacerdoti, R. De Toni, Alberto Ruol, Angelo Gatta, F. Menon, Lorenza Caregaro, Paolo Angeli, and M. Rondana

Subjects
Liver Cirrhosis, Male, medicine.medical_specialty, Lithium (medication), Metabolic Clearance Rate, Sodium, Clinical Biochemistry, chemistry.chemical_element, Renal function, Lithium, Biochemistry, Plasma renin activity, Excretion, chemistry.chemical_compound, Internal medicine, Ascites, Renin, medicine, Humans, Aldosterone, Renal sodium reabsorption, Chemistry, General Medicine, Middle Aged, Endocrinology, Kidney Tubules, Female, medicine.symptom, medicine.drug, Glomerular Filtration Rate
Abstract

Renal tubular sodium handling was evaluated in 27 non-azotemic cirrhotic patients with ascites and positive sodium balance and in 17 controls after at least 5 days of a constant sodium intake using the lithium clearance as an index of fluid delivery to the distal tubule. Plasma renin activity and plasma aldosterone were also evaluated. Sodium fractional excretion, filtered sodium load, absolute sodium distal delivery, lithium fractional excretion and absolute distal sodium reabsorption were significantly lower in cirrhotics than in controls (0.58 +/- 0.11 vs. 1.29 +/- 0.12%, P less than 0.001; 12529 +/- 677 vs. 15707 +/- 796 microEq min-1 1.73 m-2 BSA, P less than 0.005; 2384 +/- 135.2 vs. 3685 +/- 219.3 microEq min-1 1.73 m-2 BSA, P less than 0.001; 19.5 +/- 1.0 vs. 24.2 +/- 1.3%, P less than 0.01; 2299 +/- 127 vs. 3485 +/- 214 microEq min-1 1.73 m-2 BSA, P less than 0.001, respectively). A correlation was found between lithium clearance and sodium clearance only in cirrhotic patients (r = 0.62; P less than 0.01). Distal sodium reabsorption evaluated as a per cent of filtered sodium load was lower in cirrhotics than in controls (19.1 +/- 1.0 vs. 22.4 +/- 1.2%, P less than 0.05) while distal sodium reabsorption evaluated as a per cent of sodium distal delivery was higher in cirrhotics than in controls (96.7 +/- 0.4 vs. 94.4 +/- 0.5%, P less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1990

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