1. Epidemiology and antimicrobial resistance patterns of bacterial meningitis among hospitalized patients at a tertiary care hospital in Saudi Arabia: a six-year retrospective study.
- Author
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Alhazmi AH, Alameer KM, Abuageelah BM, Gharawi AY, Hakami EF, Zogel TA, Almalki AJ, Magrashi EG, Alharbi WA, Manni RM, Buayti AA, Alharbi AA, Dhayhi NS, and Haddad M
- Subjects
- Humans, Saudi Arabia epidemiology, Retrospective Studies, Female, Male, Child, Preschool, Child, Infant, Infant, Newborn, Adolescent, Adult, Young Adult, Middle Aged, Drug Resistance, Bacterial, Microbial Sensitivity Tests, Hospitalization statistics & numerical data, Pseudomonas aeruginosa drug effects, Pseudomonas aeruginosa isolation & purification, Aged, Bacteria drug effects, Bacteria isolation & purification, Bacteria classification, Bacteria genetics, Incidence, Meningitis, Bacterial epidemiology, Meningitis, Bacterial microbiology, Meningitis, Bacterial drug therapy, Tertiary Care Centers statistics & numerical data, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Cross Infection epidemiology, Cross Infection microbiology, Cross Infection drug therapy
- Abstract
Introduction: Bacterial meningitis poses significant medical challenges due to its acute inflammatory nature and potential for severe neurological complications, emphasizing the need for prompt diagnosis and treatment. Limited data exists on its epidemiology and antimicrobial resistance trends among hospitalized patients in Saudi Arabia. This study aimed to investigate these factors at a tertiary care hospital over six years., Methods: A retrospective analysis was conducted on cerebrospinal fluid samples results from 222 bacterial meningitis cases among hospitalized patients between 2018 and 2023. Demographic, clinical, microbiological data, and antibiotic susceptibility patterns were collected and analyzed., Results: Pseudomonas aeruginosa (43%) was the predominant pathogen isolated. Neonates (16%) and children (47%) were most affected population. Nosocomial meningitis accounted for 92% of cases, mainly in the intensive care settings (50.45%). Extended-spectrum beta-lactamase was the leading resistance pattern (12.2%). Seasonal variation was observed, with a peak incidence in October-November., Conclusion: The study highlights the substantial burden of bacterial meningitis among hospitalized patients, especially among high-risk groups. Emerging antimicrobial resistance emphasizes the need for optimized surveillance and stewardship. Future prospective research employing molecular techniques across multiple centers in the country is warranted to enhance understanding and guide public health strategies in Saudi Arabia., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2024
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