1. Stunting in infancy, pubertal trajectories and adult body composition: the Birth to Twenty Plus cohort, South Africa
- Author
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Glory Chidumwa, Lukhanyo H. Nyati, Shane A. Norris, Rihlat Said-Mohamed, Lisa K. Micklesfield, Alessandra Prioreschi, Tinashe Chikowore, Lisa J. Ware, Juliana Kagura, Feziwe Mpondo, Said-Mohamed, Rihlat [0000-0003-1592-5412], and Apollo - University of Cambridge Repository
- Subjects
Adult ,Adolescent ,Epidemiology ,Population ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Adult obesity ,Article ,Fat mass ,Body Mass Index ,03 medical and health sciences ,South Africa ,Young Adult ,0302 clinical medicine ,Medicine ,Humans ,692/308/174 ,030212 general & internal medicine ,Young adult ,education ,Child ,Tanner scale ,Growth Disorders ,2. Zero hunger ,education.field_of_study ,Nutrition and Dietetics ,Anthropometry ,business.industry ,Infant ,Paediatrics ,Body Height ,Child, Preschool ,Cohort ,Body Composition ,692/700/1720 ,business ,Body mass index ,human activities ,Demography - Abstract
Background/objectives Childhood rapid growth and earlier puberty onset have been associated with adult obesity. However, the association between childhood stunting, pubertal timing and adult obesity is unclear. We examined whether the relationship between stunting at age 2 years (y) and body composition at 23 years is mediated by adolescent body mass index, and pubertal development, using the Birth-to-Twenty Plus cohort (South Africa). Subjects/methods For 1036 participants, data on anthropometrics between birth and 23 years, maternal factors, and pubertal development (Tanner scale at 9–16 years) were collected. Stunting at 2 years (height-for-age z-score Results Stunting was directly associated with slower pubertal development and with shorter adult stature, but was not associated with adolescent BMI trajectories, adult FM or FFM. However, stunting was indirectly associated with adult FM and FFM through the direct associations between slower pubertal development and lower FM and between shorter height and lower FFM. BMI trajectories were independently associated with FM and FFM. Conclusions Being stunted in this population predicted adult body composition through slower pubertal development and shorter adult stature.
- Published
- 2020