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Background/objectives Alcohol is commonly consumed around mealtimes. This study hypothesized that the association between alcohol and hypertension was influenced by overall diet quality. This study aims to test the hypothesis that overall diet quality influenced associations between alcohol and risk of hypertension across different ethnicities. Subjects/methods Using nationally representative data from National Health and Nutrition Examination Survey(NHANES 03-12), China Health Nutrition Survey (CHNS), and an independent population-based study, 43,914 adults were included. Subgroup analysis included 6984 adults from CHNS with a 14-year follow-up. Light alcohol consumption was defined as 21 drinks/week. Alternative healthy eating index and diet balance index were calculated as indicators of diet quality. Results There were 3968 hypertensives in Caucasians (N = 11,325), 1976 in Africans (N = 5010), 1907 in Hispanics (N = 7274) and 5267 (N = 20,305) in Chinese. In context of high diet quality, light alcohol consumption was significantly associated with decreased risk of hypertension in Caucasians, and the risk of hypertension was not significantly increased with increasing in alcohol consumption in Caucasians, Chinese, and Hispanics (all P.sub.for trend > 0.05). On the contrary, in context of low diet quality, the risk of hypertension was significantly increased with increasing in alcohol consumption in Caucasians (P.sub.for trend = 0.005), Chinese (P.sub.for trend = 0.001) and Hispanics (P.sub.for trend = 0.022). Associations between alcohol consumption and risk of hypertension significantly varied by diet-quality scores in Caucasians, Hispanics, and Chinese (all P.sub.for interaction < 0.01) showing gradually changing from nonsignificant increasing trend to linear association. Conclusions This study firstly demonstrated that overall diet quality influenced associations between alcohol and risk of hypertension across different ethnicities, emphasizing that when examining health effects of alcohol on blood pressure, diet quality should be considered., Author(s): Wenbo Jiang [sup.1] , Xing Meng [sup.1] , Wanying Hou [sup.1] , Xiaoyan Wu [sup.1] , Yue Wang [sup.1] , Maoqing Wang [sup.1] , Xia Chu [sup.1] , Peng [...]

Background/objectives The purpose of our study was to explore the relation of prenatal exposure to the Chinese famine and the risk of metabolic syndrome in adulthood in consecutive generations. Subjects/methods A total of 960 families, including 1920 parents (F1) who were born near the time of the Great Chinese famine and 1145 of their offspring (F2), were selected from the Suihua rural area. Parental participants were defined as nonexposed (born between 1 October 1956 and 30 September 1958 or between 1 October 1962 and 30 September 1964) and famine exposed (born between 1 October 1959 and 30 September 1961). In F2, participants were divided into having no parents exposed to famine, only a mother exposed to famine, only a father exposed to famine or both parents exposed to famine. Metabolic syndrome was defined by the International Diabetes Federation criteria. Results Exposure to famine during gestation was associated with an increased risk of metabolic syndrome (odds ratio: 2.79, 95% confidence interval: 2.16, 3.60) in F1 adults. However, similar association was not observed (maternal: odds ratio: 1.33, 95% confidence interval: 0.69, 2.52; paternal: odds ratio: 1.67, 95% confidence interval: 0.87, 3.21; parental: odds ratio: 1.25, 95% confidence interval: 0.68, 2.31) in F2 adults. Conclusions Exposure to the Chinese famine during foetal life was associated with an increased risk of metabolic syndrome in F1 participants. In F2 adults, there might be an important relationship between exposure to famine and the risk of metabolic syndrome with increasing age., Author(s): Shiwei Yan [sup.1], Wanying Hou [sup.1], Huanyu Wu [sup.1], Wenbo Jiang [sup.1], Yinling Li [sup.1], Yuan Zhang [sup.1], Hongyin Li [sup.1], Sen Yang [sup.1], Changhao Sun [sup.1], Tianshu Han [...]