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Start Over Author "Bariffi, F." Journal european journal of clinical pharmacology
3 results on '"Bariffi, F."'

3. Effect of inhaled heparin on water-induced bronchoconstriction in allergic asthmatics

Author

Sa Marsico, Cm Tranfa, G. Pelaia, F. Bariffi, Alessandro Vatrella, Roberto Parrella, Tranfa, Carmelindo Mario Enrico, Vatrella, A, Parrella, R, Pelaia, G, Bariffi, F, Marsico, Sa, C. M. E., Tranfa, A., Vatrella, R., Parrella, G., Pelaia, Bariffi, Francesco, and S. A., Marsico

Subjects
Adult, Male, Allergy, Bronchoconstriction, Placebo, heparin, asthma, ultrasonic mist of distilled water, Airway responsiveness, Double-Blind Method, Forced Expiratory Volume, Administration, Inhalation, medicine, Humans, Pharmacology (medical), Asthma, Pharmacology, Analysis of Variance, Cross-Over Studies, Inhalation, business.industry, Heparin, Respiratory disease, Degranulation, Anticoagulants, Water, General Medicine, Middle Aged, medicine.disease, Anesthesia, Female, medicine.symptom, business, medicine.drug
Abstract

Objective: The aim of this study was to investigate the effect of inhaled heparin on bronchoconstriction induced by ultrasonically nebulised distilled water (UNDW) in allergic asthmatics. Methods: Eight atopic asthmatics, hyperresponsive to UNDW, were selected for this randomised, placebo-controlled, crossover double-blind study. On two consecutive days, these subjects underwent a UNDW challenge 45 min after inhaling aerosolised heparin (1000 U/kg) or placebo. Results: Neither heparin nor placebo had a significant effect on base-line forced expiratory volume in 1 s (FEV1), but heparin significantly attenuated UNDW-induced bronchoconstriction, as shown by its efficacy in preventing the decreases in FEV1 produced by all doses of water (in comparison with placebo: P

Published
2001

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