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Case 1: A 55 year-old lady presented with diffuse oedematous erythema infiltrated with numerous small non-follicular pustules. This initially appeared over her face and axillae but subsequently spread to involve much of her torso and proximal limbs. There was associated fever and general malaise. Laboratory investigations also demonstrated an accompanying neutrophilia. Five days previously she had started oral flucloxacillin for a recurrent facial cyst.Case 2: A 48 year-old lady presented with multiple [...]

The autoinflammatory syndromes are a family of disorders of dysregulated innate immunity that result in the overproduction of pro-inflammatory cytokines, in particular IL-1β [1]. The protean clinical manifestations of these diseases include: recurrent episodic fever, myalgia, arthralgia and arthritis, general malaise, and atypical urticaria or cutaneous features resembling a number of neutrophilic dermatoses, mainly pyoderma gangrenosum [2, 3]. Autoantibodies are characteristically absent. Symptom [...]

ejd.2013.2159 Auteur(s) : Kenji Sakurai beautifulskyblue58@yahoo.co.jp, Teruasa Murata, Mizue Yamamoto, Satoshi Kore-eda Department of Dermatology, Tenri Hospital, 200 Mishima-cho, Tenri, Nara 632-8552, Japan A 73-year-old Japanese woman visited our hospital mainly with complaints of fever, general malaise and multiple subcutaneous nodules. She had a 10-year history of rheumatoid arthritis (RA) and had been treated with oral methotrexate (MTX), 8 mg/week for the past 6 years. At the initial [...]