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8. Robustness of a new three-dimensional echocardiographic algorithm for left ventricular volume and ejection fraction quantification: experts vs. novices

Author

Patricia Reant, Marina Dijos, François Laurent, Mathieu Landelle, Michel Montaudon, Xavier Pillois, Olivier Corneloup, Cecile Touche, Florence Arsac, Laurence Barbot, Stephane Lafitte, and Raymond Roudaut

Subjects
Male, medicine.medical_specialty, Systole, Statistics as Topic, Diastole, Magnetic Resonance Imaging, Cine, Endocardial border, Ventricular Function, Left, Cardiac magnetic resonance imaging, Internal medicine, Confidence Intervals, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Reproducibility, Ejection fraction, medicine.diagnostic_test, business.industry, Two dimensional echocardiography, Stroke Volume, General Medicine, Middle Aged, Confidence interval, Echocardiography, Cardiology, Ventricular volume, Female, Clinical Competence, Cardiology and Cardiovascular Medicine, business, Algorithm, Algorithms
Abstract

Aims We evaluated the ability of a new simplified algorithm for three-dimensional echocardiography (3DE) left ventricular (LV) measurements with minimal operator interaction to be reproducible and robust, independently of the experience. Methods and results A total of 163 subjects were investigated using two-dimensional echocardiography (2DE) and 3DE. The 3D data sets were blindly analysed offline by novice investigators and experts. A subgroup of 30 patients was assessed using cardiac magnetic resonance imaging (CMRI) to compare end-diastolic volume (EDV), end-systolic volume (ESV), and ejection fraction (EF) obtained by 2DE, 3DE, and CMRI. Intra-observer and inter-observer variabilities of 2DE and 3DE measurements were evaluated according to level of experience. Mean time analysis of 3DE data was 23.2 ± 6.3s for the novice and 26.1 ± 4.1 s for the expert ( P = ns). Correlations ( r ) and mean error measurements (MEM) between 3DE analysis by experts and novices were 0.91 and −3.5 mL for EDV, 0.97 and 4.3 mL for ESV, and 0.91 and −2.6% for EF, respectively. Correlations between 3DE and CMRI were good with low variability and greater agreement when compared with those between 2DE and CMRI. For the novice, MEM was −21.3 mL for EDV, −15.0 mL for ESV, and 2.3% for EF. MEM and 95% confidence intervals were wider for 2DE vs. CMRI than for 3DE vs. CMRI in relation to both expert and novice. Conclusion This new semi-automated algorithm of LV endocardial border detection based on 3DE data appears suitable for clinical use by either expert or novice investigators with greater reproducibility and time of analysis than 2DE.

Published
2011
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9. Poster session I * Thursday 9 December 2010, 08:30-12:30

Author

V. A. Kuznetsov, A. O. Kozhurina, A. V. Plusnin, M. Szulik, B. Sredniawa, W. Streb, R. Lenarczyk, J. Stabryla-Deska, A. Sedkowska, O. Kowalski, Z. Kalarus, T. Kukulski, T. M. Katova, A. Nesheva, I. Simova, K. Hristova, V. Kostova, L. Boiadjiev, N. Dimitrov, M. P. Papamichalis Michalis, S. G. Sitafidis George, B. D. Dimopoulos Basilios, G. K. Kelepesis Glafkos, D. E. Economou Dimitrios, J. S. Skoularigis John, F. T. Triposkiadis Filippos, C. H. Attenhofer Jost, M. Pfyffer, B. Naegeli, P. Levis, A. Faeh-Gunz, H. P. Brunner-Larocca, M. S. Velasco Del Castillo, A. Cacicedo, J. J. Onaindia, J. Gonzalez Ruiz, A. Subinas, J. A. Alarcon, O. Quintana, I. Rodriguez, E. Laraudogoitia, Y.-Y. Lam, M. Y. Henein, A. Mazzone, A. Vianello, S. Perlini, A. I. Corciu, S. Cappelli, A. Cerillo, D. Chiappino, S. Berti, M. Glauber, S. Herrmann, M. Niemann, S. Stoerk, J. Strotmann, W. Voelker, G. Ertl, F. Weidemann, Z. Y. Yong, K. Boerlage - Van Dijk, K. T. Koch, M. M. Vis, B. J. Bouma, J. P. S. Henriques, R. Cocchieri, B. A. J. M. De Mol, J. J. Piek, J. Baan, N. G. J. Keenan, C. Cueff, C. Cimadevilla, E. Brochet, L. Lepage, D. Detaint, B. Iung, A. Vahanian, D. Messika-Zeitoun, T. Otsuka, M. Suzuki, H. Yoshikawa, G. Hashimoto, T. Osaki, T. Tsuchida, M. Matsuyama, H. Yamashita, S. Ozaki, K. Sugi, C. J. Garcia Alonso, N. Vallejo Camazon, E. Ferrer Sistach, M. L. Camara, J. Lopez Ayerbe, C. Bosch Carabante, M. Espriu Simon, F. Gual Capllonch, A. Bayes Genis, G. Deswarte, C. Vanesson, A. S. Polge, D. Huchette, T. Modine, P. Marboeuf, N. Lamblin, C. Bauters, G. Deklunder, T. Le Tourneau, A. Agricola, M. Gullace, S. Stella, R. D'amato, M. Slavich, M. Oppizzi, M. Ancona, A. Margonato, F. Le Ven, Y. Etienne, Y. Jobic, I. Frachon, P. Castellant, M. Fatemi, J. J. Blanc, M. Muratori, P. Montorsi, F. Maffessanti, P. Gripari, G. Teruzzi, S. Ghulam Ali, L. Fusini, F. Celeste, M. Pepi, B. Goebel, K. Haugaa, K. Meyer, S. Otto, A. Lauten, C. Jung, T. Edvardsen, H. R. Figulla, T. C. Poerner, H. Aksoy, S. Okutucu, B. Evranos, K. Aytemir, E. B. Kaya, G. Kabakci, L. Tokgozoglu, H. Ozkutlu, A. Oto, N. Valeur, H. H. Pedersen, R. Videbaek, C. Hassager, J. H. Svendsen, L. Kober, M. K. Tigen, T. Karaahmet, E. Gurel, S. Pala, C. Dundar, Y. Basaran, C. I. Caldararu, E. Ene, M. Dorobantu, R. G. Vatasescu, M. Cikes, B. Bijnens, H. Gasparovic, F. Siric, V. Velagic, D. Lovric, J. Samardzic, B. Ferek-Petric, D. Milicic, B. Biocina, J. Kjaergaard, S. Ghio, M. St John Sutton, O. Moreau, G. Kervio, C. Thebault, C. Leclercq, E. Donal, C. Mornos, D. Rusinaru, L. Petrescu, D. Cozma, A. Ionac, S. Pescariu, S. I. Dragulescu, M. Z. Petrovic, B. Vujisic-Tesic, G. Milasinovic, M. T. Petrovic, I. Nedeljkovic, D. Zamaklar-Trifunovic, Z. Calovic, V. Jelic, M. Boricic, I. Petrovic, P. Kuchynka, T. Palecek, S. Simek, E. Nemecek, J. Horak, D. Hulinska, J. Schramlova, I. Vitkova, V. Aster, A. Linhart, L. Paluszkiewicz, D. Guersoy, S. Ozegowski, S. Spiliopoulos, R. Koerfer, G. Tenderich, M. Gaggl, G. Heinze, G. Sunder-Plassmann, S. Graf, M. Zehetmayer, T. Voigtlaender, C. Mannhalter, E. Paschke, G. Fauler, G. Mundigler, M. Tesic, D. Trifunovic, A. Djordjevic-Dikic, O. Petrovic, M. Petrovic, B. Beleslin, M. Ostojic, G. Draganic, C. E. Correia, B. Rodrigues, L. F. Santos, D. Moreira, P. Gama, L. Nunes, C. Nascimento, O. Dionisio, O. Santos, C. Prinz, O. Oldenburg, T. Bitter, C. Piper, D. Horstkotte, L. Faber, A. Nemes, H. Gavaller, M. Csanady, T. Forster, M. Calcagnino, C. O'mahony, K. Tsovolas, P. D. Lambiase, P. Elliott, A. S. Olezac, A. Bensaid, J. Nahum, E. Teiger, J. L. Dubois-Rande, P. Gueret, P. Lim, C. Langer, M. Kansal, P. Surapaneni, P. P. Sengupta, S. J. Lester, S. R. Ommen, S. W. Ressler, R. T. Hurst, V. Monivas Palomero, S. Mingo Santos, C. Mitroi, I. Garcia Lunar, P. Garcia Pavia, J. Gonzalez Mirelis, L. Ruiz Bautista, V. Castro Urda, J. Toquero Ramos, I. Fernandez Lozano, A. Sommer, S. H. Poulsen, J. Mogensen, L. Thuesen, H. Egeblad, R. Montisci, M. Ruscazio, A. Vacca, P. Garau, F. Tuveri, C. Soro, A. Matthieu, L. Meloni, W. Kosmala, M. Przewlocka-Kosmala, A. Wojnalowicz, A. Mysiak, T. H. Marwick, R. Yotti, C. Ripoll, J. Bermejo, Y. Benito, T. Mombiela, D. Rincon, A. Barrio, R. Banares, F. Fernandez-Aviles, A. Tomaszewski, A. Kutarski, M. Tomaszewski, R. Ticulescu, O. Vriz, L. Sparacino, B. A. Popescu, C. Ginghina, G. L. Nicolosi, S. Carerj, F. Antonini-Canterin, E. Agricola, L. Bertoglio, G. Melissano, R. Chiesa, S. Garcia Blas, D. Iglesias Del Valle, T. Lopez Fernandez, J. J. Gomez De Diego, M. C. Monedero Martin, F. J. Dominguez, M. Moreno Yanguela, J. L. Lopez Sendon, S. Adhya, F. D. Murgatroyd, M. Monaghan, L. Spinarova, J. Meluzin, P. Hude, J. Krejci, H. Podrouzkova, M. Pesl, R. Panovsky, L. Dusek, M. Orban, J. Korinek, C. Hammerstingl, M. Schwiekendik, G. Nickenig, D. Momcilovic, L. Lickfett, C. C. Beladan, A. Calin, M. Rosca, D. Muraru, F. Voinea, E. Popa, F. Matei, F. Curea, G. Di Salvo, G. Pacileo, S. Gala, B. Castaldi, A. F. D'aiello, A. Mormile, L. Baldini, M. G. Russo, R. Calabro, P. S. Halvorsen, G. Dahle, J. F. Bugge, B. Bendz, L. Aaberge, K. A. Rein, A. Fiane, J. Bergsland, E. Fosse, S. Aakhus, L. P. Koopman, N. Chahal, C. Slorach, W. Hui, T. Sarkola, C. Manlhiot, T. J. Bradley, E. T. Jaeggi, B. W. Mccrindle, L. Mertens, F. A. D'aiello, A. Mormilw, A. Rea, K. O'Connor, G. Romano, J. Magne, L. Pierard, P. Lancellotti, T. Arita, K. Ando, A. Isotani, Y. Soga, M. Iwabuchi, M. Nobuyoshi, M. Wiesen, D. Skowasch, F. Breunig, M. Beer, K. Hu, C. Wanner, M. A. Morel, Y. F. Bernard, V. Descotes-Genon, N. Meneveau, F. Schiele, A. Vitarelli, M. Bernardi, A. Scarno, F. Caranci, V. Padella, O. Dettori, L. Capotosto, M. Vitarelli, V. De Cicco, P. Bruno, G. Bajraktari, P. Lindqvist, U. Gustafsson, A. Holmgren, M. Hassan, K. Said, E. Baligh, H. Farouk, D. Osama, M. F. Elmahdy, A. Elfaramawy, K. Sorour, M. Luckie, A. Zaidi, A. Fitzpatrick, R. S. Khattar, J. Schwartz, O. Huttin, B. Popovic, P. Y. Zinzius, C. Christophe, O. Marcon, L. Groben, Y. Juilliere, F. Chabot, C. Selton-Suty, B. Krastev, E. T. K. Kinova, N. I. Z. Zlatareva, A. R. G. Goudev, A. J. Teske, B. W. De Boeck, F. A. Mohames Hoesein, V. Van Driel, P. Loh, M. J. Cramer, P. A. Doevendans, F. Dillenburg, K. M. Abd El Salam, E. M. M. Ho, M. Hall, L. Hemeryck, K. Bennett, K. Scott, G. King, R. T. Murphy, A. Mahmud, A. S. Brown, H. Dalen, A. Thorstensen, P. R. Romundstad, S. A. Aase, A. Stoylen, L. Vatten, T. Bochenek, K. Wita, Z. Tabor, A. Doruchowska, M. Lelek, M. Trusz-Gluza, E. Hamodraka, I. Paraskevaidis, A. Karamanou, C. Michalakeas, H. Vrettou, E. Kapsali, D. Tsiapras, I. Lekakis, M. Anastasiou-Nana, D. Kremastinos, L. Sirugo, V. E. Bottari, S. Licciardi, A. Blundo, A. Atanasio, I. P. Monte, C. S. Park, J. H. Kim, J. S. Cho, M. J. Kim, E. J. Cho, S. H. Ihm, H. O. Jung, H. K. Jeon, H. J. Youn, K. S. Kim, A. Fontana, L. Taravella, A. Zambon, G. Trocino, C. Giannattasio, A. Kalinin, M. Alekhin, G. Bahs, A. Lejnieks, A. Kalvelis, A. Kalnins, P. Shipachovs, E. Zakharova, G. Blumentale, M. Trukshina, T. Biering-Sorensen, R. Mogelvang, S. Haahr-Pedersen, P. Schnohr, P. Sogaard, J. Skov Jensen, L. Gargani, G. Agoston, E. Capati, L. Badano, A. Moreo, M. F. Costantino, M. L. Caputo, S. Mondillo, R. Sicari, E. Picano, E. G. Malev, E. V. Timofeev, S. V. Reeva, E. V. Zemtsovsky, R. Piazza, R. Enache, A. Roman-Pognuz, E. Leiballi, R. Pecoraro, H. Sadeghian, M. Lotfi_Tokaldany, M. Rezvanfard, A. Kasemisaeid, S. Majidi, M. Montazeri, M. Saber-Ayad, Y. S. Nassar, A. Farhan, A. Moussa, A. El-Sherif, R. M. Cooper, J. D. Somauroo, R. E. Shave, K. L. Williams, J. Forster, C. George, T. Bett, D. C. Gaze, K. P. George, N. Mansencal, A. Dupland, V. Caille, S. Perrot, K. Bouferrache, A. Vieillard-Baron, R. Jouffroy, S. G. Cioroiu, O. S. Alexe, E. Bobescu, H. Rus, V. Schiano Lomoriello, R. Esposito, A. Santoro, R. Raia, F. Farina, R. Ippolito, M. Galderisi, E. H. Aburawi, P. Malcus, A. Thuring, A. Maxedius, E. Pesonen, S. V. Nair, E. Joyce, L. Lee, J. Shrimpton, E. Newman, P. R. James, C. Jurcut, S. Caraiola, R. O. Jurcut, S. Giusca, D. Nitescu, M. S. Amzulescu, I. Copaci, C. Tanasescu, J. Silva Marques, D. Silva, F. Ferreira, P. C. Ferreira, A. G. Almeida, J. Martim Martins, M. G. Lopes, L. Bergenzaun, M. Chew, A. Ersson, P. Gudmundsson, H. Ohlin, A. Borowiec, R. Dabrowski, J. Wozniak, S. Jasek, T. Chwyczko, I. Kowalik, E. Musiej-Nowakowska, H. Szwed, Y. L. Wen, J. Tian, L. Yan, H. Cheng, H. Yang, B. Luo, J. Wang, H. Kozman, D. Villarreal, K. Liu, A. Karavidas, D. Tsiachris, G. Lazaros, V. Matzaraki, G. Xylomenos, G. Levendopoulos, S. Arapi, A. Perpinia, E. Matsakas, V. Pyrgakis, Y. W. Liu, C. T. Su, W. C. Tsai, J. W. Huang, K. Y. Hung, J. H. Chen, M. Larsson, F. Kremer, T. Kouznetsova, A. Bjallmark, B. Lind, L.-A. Brodin, J. D'hooge, M. Caputo, G. Antonelli, M. Lisi, E. Giacomin, S. Moustafa, M. Alharthi, Y. Deng, K. Chandrasekaran, F. Mookadam, S. Y. Hayashi, M. M. Nascimento, B. Lindholm, A. Seeberger, J. Nowak, M. C. Riella, L. A. Brodin, A. Theodosis, E. Fousteris, G. Tsiaousis, A. Krommydas, P. Margetis, Z. Katidis, D. Beldekos, S. Argirakis, A. Melidonis, S. Foussas, O. Khaleva, O. Onyshchenko, E. Lukaschuk, N. Sherwi, N. Nikitin, J. G. F. Cleland, N. Risum, C. Jons, N. T. Olsen, M. B. Kronborg, M. T. Jensen, T. Fritz-Hansen, N. E. Bruun, M. V. Hojgaard, J. Petrini, M. Yousry, A. Rickenlund, J. Liska, A. Franco-Cereceda, A. Hamsten, P. Eriksson, K. Caidahl, M. J. Eriksson, N. Elmstedt, K. Ferm-Widlund, M. Westgren, E. Szymczyk, J. D. Kasprzak, B. Wozniakowski, A. Rotkiewicz, K. Szymczyk, L. Stefanczyk, B. Michalski, P. Lipiec, L. Ring, T. Eller, P. Deegan, R. Rusk, J. A. Urbano Moral, J. A. Arias, J. T. Kuvin, A. R. Patel, N. G. Pandian, H. Bellsham-Revell, A. J. Bell, O. Miller, G. F. Greil, J. Simpson, R. Ancona, S. Comenale Pinto, P. Caso, S. Severino, L. Nunziata, T. Roselli, C. Dussault, S. Lafitte, G. Habib, P. Reant, G. Derumeaux, H. Thibault, A. Kaladaridis, I. A. Agrios, C. P. Pamboucas, S. M. Mesogitis, N. V. Vasiladiotis, D. B. Bramos, S. T. T. Toumanidis, A. R. Martiniello, G. Santangelo, G. Pedrizzetti, G. Tonti, C. Cioppa, M. Cavallaro, V. Calvi, and R. Chianese

Subjects
Speckle pattern, Longitudinal strain, business.industry, Carotid arteries, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, business, Tracking (particle physics), Biomedical engineering
Abstract

Radial and longitudinal strain assessment in the carotid artery wall using speckle tracking

Published
2010
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10. Systolic time intervals as simple echocardiographic parameters of left ventricular systolic performance: correlation with ejection fraction and longitudinal two-dimensional strain

Author

Philippe Ritter, Pierre Dos Santos, Aude Mignot, Christophe Leclercq, Raymond Roudaut, Patricia Reant, Stephane Lafitte, Marina Dijos, Erwan Donal, Pierre Bordachar, and Gilbert Habib

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Systole, Left Ventricular Ejection Time, Context (language use), Sensitivity and Specificity, Doppler imaging, Electrocardiography, Ventricular Dysfunction, Left, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Heart Failure, Analysis of Variance, Ejection fraction, medicine.diagnostic_test, business.industry, Reproducibility of Results, General Medicine, Stroke volume, Middle Aged, medicine.disease, Echocardiography, Doppler, Area Under Curve, Case-Control Studies, Heart failure, Linear Models, cardiovascular system, Cardiology, Female, Cardiomyopathies, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology
Abstract

Conventionally, the evaluation of left ventricular (LV) systolic function is based on ejection fraction assessment, which may be supplemented by other echocardiographic techniques, such as tissue Doppler imaging, 3D evaluation, and speckle tracking strains. However, these imaging modalities have a high technicity and are time-consuming, while being associated with reproducibility limitations. In this context, the usefulness of simpler measurements such as sys- tolic time intervals (STI) by pulsed Doppler echocardiography must be emphasized. Methods and results In this multicentre study, left ventricular ejection fraction (LVEF), dP/dtmax, LV stroke volume, myocardial longitudinal deformation, aortic pre-ejectional period (PEP, ms), and left ventricular ejection time (LVET, ms) were prospectively investigated and compared in 134 consecutive heart failure (HF) patients and 43 control subjects. Feasibility of STI measurements was 100%. Intra-observer reproducibility was 98% for PEP, 96% for LVET, 87% for LVEF, and 93% for global longitudinal strain (GLS). By subgroup analyses, with increasingly altered LVEF or GLS, PEP significantly increased, whereas significantly LVET decreased, resulting in a significantly increased PEP/LVET ratio (P , 0.001). In the HF patients group, a correlation between LVEF and PEP/LVET was found, with r ¼ 0.55 (y ¼ 20.0083x + 0.75, P , 0.001). Based on receiver operating curve analyses, the area under the curve was 0.91 for PEP/LVET . 0.43, which allowed us to detect LVEF , 35% with a sensitivity of 87%, and a specificity of 84%. Conclusion STI can be easily and accurately measured in clinical practice, and may be used for detecting alterations in LV systolic function. Moreover, this method is likely to have potential applications in the management of HF patients.

Published
2010
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11. Effect of cardiac resynchronization therapy on regional left ventricular function: a speckle tracking strain analysis

Author

Patricia Reant, Robert Amyot, Pierre Bordachar, Raymond Roudaut, Karim Serri, Claude Sauvé, and Stephane Lafitte

Subjects
Male, medicine.medical_specialty, Contraction (grammar), Manometry, medicine.medical_treatment, Cardiac resynchronization therapy, Diastole, Ventricular Function, Left, Contractility, Internal medicine, medicine, Humans, Fluoroscopy, Radiology, Nuclear Medicine and imaging, Systole, Aged, Heart Failure, Lateral strain, Ejection fraction, medicine.diagnostic_test, business.industry, Myocardium, Cardiac Pacing, Artificial, General Medicine, Myocardial Contraction, Echocardiography, Doppler, Treatment Outcome, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Echocardiography, Stress
Abstract

Aims The mechanisms associated with cardiac resynchronization therapy (CRT) benefits have been elucidated in part, however little is known about the effects of biventricular pacing (BVP) on regional myocardial contractility. Methods and results Twenty patients with conventional CRT criteria were studied before and after device implantation. Speckle tracking strain analysis was performed from standard bidimensional acquisitions during different pacing configurations. Longitudinal and transverse strains were measured for the six basal left ventricular (LV) segments. Acute CRT improved LV end-diastolic and end-systolic volumes without significantly modifying LV ejection fraction. Moreover, CRT produced significant changes in regional strain. When compared with spontaneous rhythm, simultaneous BVP caused a significant increase in longitudinal septal strain (−4.8 vs. −7.3%, P = 0.003) and a significant decrease in longitudinal lateral strain (−8.2 vs. −5.9%, P = 0.03). Simultaneous BVP also induced a significant decrease in transverse lateral strain from 17.9 to 10.9% ( P = 0.004). Conclusion In this acute echocardiographic study, BVP decreased lateral wall deformation while improving septal wall contraction, thus potentially improving LV contractile pattern.

Published
2009
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12. Usefulness of right ventricular isovolumic relaxation time in predicting systolic pulmonary artery pressure

Author

Raymond Roudaut, Laetitia Gambotti, Nicolas Bréchot, and Stephane Lafitte

Subjects
Adult, Male, Cardiac Catheterization, medicine.medical_specialty, Systole, Heart Ventricles, Hypertension, Pulmonary, Ventricular Dysfunction, Right, medicine.medical_treatment, Blood Pressure, Pulmonary Artery, Doppler echocardiography, Doppler imaging, Predictive Value of Tests, Internal medicine, medicine.artery, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Prospective Studies, Prospective cohort study, Aged, Cardiac catheterization, Aged, 80 and over, medicine.diagnostic_test, business.industry, Reproducibility of Results, General Medicine, Middle Aged, Myocardial Contraction, Echocardiography, Doppler, Radiography, stomatognathic diseases, Blood pressure, Predictive value of tests, Pulmonary artery, Cardiology, Feasibility Studies, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Aims Systolic pulmonary artery pressure (sPAP) cannot always be assessed from Doppler-detected tricuspid regurgitation (TR), especially when sPAP is normal. The right ventricular isovolumic relaxation time (rIVRT) is related to sPAP, and assessment of rIVRT by tissular Doppler imaging (rIVRT 0 ) has recently been proposed as an alternative method for estimating sPAP in patients with pulmonary artery hypertension (PAH). We evaluated here its usefulness in everyday clinical practice. Methods and results We conducted a prospective Doppler vs. catheterization study in 26 patients. TR was undetectable in 6 patients (32%) with normal sPAP and in one patient (14%) from those with PAH. rIVRT 0 was recordable in all patients. We found a strong correlation between rIVRT 0 and sPAP (r ¼ 0.87; P , 0.0001). rIVRT 0 had a high sensitivity in detecting PAH, and a rIVRT 0 of 40 ms or less excluded PAH with a negative predictive value of 100%. We also found that a prolonged rIVRT 0 is not specific to PAH and that the rIVRT 0 -evaluated sPAP did not agree well with the catheter-evaluated value. Conclusion Measurement of rIVRT 0 can help estimate sPAP in the absence of TR: A normal rIVRT 0 excludes PAH with a high negative predictive value. A prolonged rIVRT 0 is in favour of an elevated sPAP but cannot

Published
2008
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13. Moderated Poster Sessions 1: Valvular heart disease: from bench to bedside * Thursday 8 December 2011, 08:30-12:30 * Location: Moderated Poster Area

Author

M. Weber, R. Schueler, D. Momcilovic, J. Sinning, A. Ghanem, N. Werner, G. Nickenig, C. Hammerstingl, B. Sun, K. Hwang, M. Cho, W. Lee, S. Choi, Y.-G. Kim, D.-H. Kim, J.-M. Song, D.-H. Kang, J.-K. Song, R. Capoulade, M. Clavel, J. Dumesnil, K. Chan, J. Tam, K. Teo, N. Cote, P. Mathieu, J. Despres, P. Pibarot, L. Macron, P. Lim, A. Bensaid, J. Nahum, D. Attias, D. Messika Zeitoun, J. Dubois Rande, P. Gueret, J. Monin, T. Le Tourneau, A. Lardeux, A. Garcia, F. Kyndt, J. Merot, A. Hagege, R. Levine, J. Schott, H. La Marec, V. Probst, K. Niki, M. Sugawara, I. Takamisawa, H. Watanabe, T. Sumiyoshi, S. Hosoda, S. Takanashi, F. Veronesi, E. Caiani, L. Fusini, G. Tamborini, L. Sugeng, F. Alamanni, M. Pepi, R. Lang, P. Gripari, M. Muratori, N. Ajmone Marsan, S. Hooi Ewe, C. Arnold, F. Van Der Kley, J. Bax, J. Adda, C. Mielot, F. Cransac, X. Zirphile, P. Reant, C. Sportouch-Dukhan, S. Lafitte, E. Donal, P. Lancellotti, G. Habib, O. Akbar Ali, M. Chapman, T. Nguyen, Y. Chirkov, and J. Horowitz

Subjects
medicine.medical_specialty, business.industry, Thursday, valvular heart disease, medicine, Physical therapy, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, medicine.disease, business, Bench to bedside
Published
2011
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16. 288 Automated Function Imaging (AFI): A new onboard and clinically applicable method of LV global function assessment by speckle tracking

Author

P. Dos Santos, H. Hurger Goldsmith, Stéphane Lafitte, Raymond Roudaut, Marianne Lafitte, Stephanie Brette, and P. Reant

Subjects
Speckle pattern, business.industry, Global function, Medicine, Radiology, Nuclear Medicine and imaging, Computer vision, General Medicine, Artificial intelligence, Function (mathematics), Cardiology and Cardiovascular Medicine, Tracking (particle physics), business
Published
2006
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17. 960 Myocardial deformation by bidimensional strain in professional football players: comparison with controls and hypertrophic cardiomyopathy

Author

S. Lafitte, A. Chalabi, Akem Kerouani, Raymond Roudaut, P. Reant, V. Richand, Marianne Lafitte, and Karim Serri

Subjects
medicine.medical_specialty, Football players, business.industry, Hypertrophic cardiomyopathy, Strain (injury), General Medicine, Football, Deformation (meteorology), medicine.disease, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business
Published
2006
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18. Cardiac hemangioma presenting as atypical chest pain

Author

Raymond Roudaut, Philippe Schraub, Karim Serri, and Stephane Lafitte

Subjects
Adult, Male, Chest Pain, medicine.medical_specialty, business.industry, Cardiac hemangioma, Atypical chest pain, General Medicine, medicine.disease, Chest pain, Heart Neoplasms, Hemangioma, Dyspnea, Humans, Medicine, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Radiology, Ultrasonography, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

A 44-year-old man presented with atypical chest pain and dyspnea. Investigation revealed the presence of a 15-mm rounded, well-vascularized left-ventricular mass. The mass was removed surgically and histopathologic evaluation identified a cardiac hemangioma.

Published
2007
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19. 805 Three-dimensional ventricular dyssynchrony: a fast and reliable parameter to optimize sequential biventricular pacing

Author

Karim Serri, Jacques Clementy, Sylvain Reuter, P. Reant, Pierre Bordachar, Michel Haïssaguerre, Stéphane Lafitte, and R. Roudaut

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Cardiology, medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, Ventricular dyssynchrony, medicine.disease, business
Published
2005
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20. Moderated Poster Sessions 1: Valvular heart disease: from bench to bedside * Thursday 8 December 2011, 08:30-12:30 * Location: Moderated Poster Area

Author

Weber, M., primary, Schueler, R., additional, Momcilovic, D., additional, Sinning, J., additional, Ghanem, A., additional, Werner, N., additional, Nickenig, G., additional, Hammerstingl, C., additional, Sun, B., additional, Hwang, K., additional, Cho, M., additional, Lee, W., additional, Choi, S., additional, Kim, Y.-G., additional, Kim, D.-H., additional, Song, J.-M., additional, Kang, D.-H., additional, Song, J.-K., additional, Capoulade, R., additional, Clavel, M., additional, Dumesnil, J., additional, Chan, K., additional, Tam, J., additional, Teo, K., additional, Cote, N., additional, Mathieu, P., additional, Despres, J., additional, Pibarot, P., additional, Macron, L., additional, Lim, P., additional, Bensaid, A., additional, Nahum, J., additional, Attias, D., additional, Messika Zeitoun, D., additional, Dubois Rande, J., additional, Gueret, P., additional, Monin, J., additional, Le Tourneau, T., additional, Lardeux, A., additional, Garcia, A., additional, Kyndt, F., additional, Merot, J., additional, Hagege, A., additional, Levine, R., additional, Schott, J., additional, La Marec, H., additional, Probst, V., additional, Niki, K., additional, Sugawara, M., additional, Takamisawa, I., additional, Watanabe, H., additional, Sumiyoshi, T., additional, Hosoda, S., additional, Takanashi, S., additional, Veronesi, F., additional, Caiani, E., additional, Fusini, L., additional, Tamborini, G., additional, Sugeng, L., additional, Alamanni, F., additional, Pepi, M., additional, Lang, R., additional, Gripari, P., additional, Muratori, M., additional, Ajmone Marsan, N., additional, Hooi Ewe, S., additional, Arnold, C., additional, Van Der Kley, F., additional, Bax, J., additional, Adda, J., additional, Mielot, C., additional, Cransac, F., additional, Zirphile, X., additional, Reant, P., additional, Sportouch-Dukhan, C., additional, Lafitte, S., additional, Donal, E., additional, Lancellotti, P., additional, Habib, G., additional, Akbar Ali, O., additional, Chapman, M., additional, Nguyen, T., additional, Chirkov, Y., additional, and Horowitz, J., additional

Published
2011
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21. Moderated Posters session III: Novel techniques of analysis * Friday 10 December 2010, 10:00-11:00

Author

Comenale Pinto, S., primary, Ancona, R., additional, Caso, P., additional, Severino, S., additional, Nunziata, L., additional, Roselli, T., additional, Calabro, R., additional, Stoylen, A., additional, Aase, S., additional, Bjastad, T., additional, Langeland, S., additional, Rabben, S. I., additional, Heimdal, A., additional, Gerard, O., additional, Ejlersen, J. A., additional, May, O., additional, Ting, P., additional, Choy, J., additional, Sonnenberg, B., additional, Becher, H., additional, Asplund, E., additional, Gustafsson, U., additional, Ronn, F., additional, Jensen, S., additional, Karp, K., additional, Waldenstrom, A., additional, Jaussaud, J., additional, Barandon, L., additional, Reant, P., additional, Calderon, J., additional, Duplaa, C., additional, Leroux, L., additional, Dos Santos, P., additional, Roudaut, R., additional, Couffinhal, T., additional, Lafitte, S., additional, Dhutia, N. M., additional, Cole, G., additional, Willson, K., additional, Pabari, P., additional, Rueckert, D., additional, Parker, K. H., additional, Hughes, A. D., additional, Francis, D. P., additional, Seo, J.-S., additional, Kim, D.-H., additional, Jung, Y. J., additional, Kang, J. H., additional, Seo, D. J., additional, Song, J.-M., additional, Kang, D.-H., additional, Song, J.-K., additional, Cameli, M., additional, Lisi, M., additional, Padeletti, M., additional, Bernazzali, S., additional, Tsoulpas, C., additional, Maccherini, M., additional, Ballo, P., additional, and Mondillo, S., additional

Published
2010
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22. Poster session I * Thursday 9 December 2010, 08:30-12:30

Author

Kuznetsov, V. A., primary, Kozhurina, A. O., additional, Plusnin, A. V., additional, Szulik, M., additional, Sredniawa, B., additional, Streb, W., additional, Lenarczyk, R., additional, Stabryla-Deska, J., additional, Sedkowska, A., additional, Kowalski, O., additional, Kalarus, Z., additional, Kukulski, T., additional, Katova, T. M., additional, Nesheva, A., additional, Simova, I., additional, Hristova, K., additional, Kostova, V., additional, Boiadjiev, L., additional, Dimitrov, N., additional, Papamichalis Michalis, M. P., additional, Sitafidis George, S. G., additional, Dimopoulos Basilios, B. D., additional, Kelepesis Glafkos, G. K., additional, Economou Dimitrios, D. E., additional, Skoularigis John, J. S., additional, Triposkiadis Filippos, F. T., additional, Attenhofer Jost, C. H., additional, Pfyffer, M., additional, Naegeli, B., additional, Levis, P., additional, Faeh-Gunz, A., additional, Brunner-Larocca, H. P., additional, Velasco Del Castillo, M. S., additional, Cacicedo, A., additional, Onaindia, J. J., additional, Gonzalez Ruiz, J., additional, Subinas, A., additional, Alarcon, J. A., additional, Quintana, O., additional, Rodriguez, I., additional, Laraudogoitia, E., additional, Lam, Y.-Y., additional, Henein, M. Y., additional, Mazzone, A., additional, Vianello, A., additional, Perlini, S., additional, Corciu, A. I., additional, Cappelli, S., additional, Cerillo, A., additional, Chiappino, D., additional, Berti, S., additional, Glauber, M., additional, Herrmann, S., additional, Niemann, M., additional, Stoerk, S., additional, Strotmann, J., additional, Voelker, W., additional, Ertl, G., additional, Weidemann, F., additional, Yong, Z. Y., additional, Boerlage - Van Dijk, K., additional, Koch, K. T., additional, Vis, M. M., additional, Bouma, B. J., additional, Henriques, J. P. S., additional, Cocchieri, R., additional, De Mol, B. A. J. M., additional, Piek, J. J., additional, Baan, J., additional, Keenan, N. G. J., additional, Cueff, C., additional, Cimadevilla, C., additional, Brochet, E., additional, Lepage, L., additional, Detaint, D., additional, Iung, B., additional, Vahanian, A., additional, Messika-Zeitoun, D., additional, Otsuka, T., additional, Suzuki, M., additional, Yoshikawa, H., additional, Hashimoto, G., additional, Osaki, T., additional, Tsuchida, T., additional, Matsuyama, M., additional, Yamashita, H., additional, Ozaki, S., additional, Sugi, K., additional, Garcia Alonso, C. J., additional, Vallejo Camazon, N., additional, Ferrer Sistach, E., additional, Camara, M. L., additional, Lopez Ayerbe, J., additional, Bosch Carabante, C., additional, Espriu Simon, M., additional, Gual Capllonch, F., additional, Bayes Genis, A., additional, Deswarte, G., additional, Vanesson, C., additional, Polge, A. S., additional, Huchette, D., additional, Modine, T., additional, Marboeuf, P., additional, Lamblin, N., additional, Bauters, C., additional, Deklunder, G., additional, Le Tourneau, T., additional, Agricola, A., additional, Gullace, M., additional, Stella, S., additional, D'amato, R., additional, Slavich, M., additional, Oppizzi, M., additional, Ancona, M., additional, Margonato, A., additional, Le Ven, F., additional, Etienne, Y., additional, Jobic, Y., additional, Frachon, I., additional, Castellant, P., additional, Fatemi, M., additional, Blanc, J. J., additional, Muratori, M., additional, Montorsi, P., additional, Maffessanti, F., additional, Gripari, P., additional, Teruzzi, G., additional, Ghulam Ali, S., additional, Fusini, L., additional, Celeste, F., additional, Pepi, M., additional, Goebel, B., additional, Haugaa, K., additional, Meyer, K., additional, Otto, S., additional, Lauten, A., additional, Jung, C., additional, Edvardsen, T., additional, Figulla, H. R., additional, Poerner, T. C., additional, Aksoy, H., additional, Okutucu, S., additional, Evranos, B., additional, Aytemir, K., additional, Kaya, E. B., additional, Kabakci, G., additional, Tokgozoglu, L., additional, Ozkutlu, H., additional, Oto, A., additional, Valeur, N., additional, Pedersen, H. H., additional, Videbaek, R., additional, Hassager, C., additional, Svendsen, J. H., additional, Kober, L., additional, Tigen, M. K., additional, Karaahmet, T., additional, Gurel, E., additional, Pala, S., additional, Dundar, C., additional, Basaran, Y., additional, Caldararu, C. I., additional, Ene, E., additional, Dorobantu, M., additional, Vatasescu, R. G., additional, Cikes, M., additional, Bijnens, B., additional, Gasparovic, H., additional, Siric, F., additional, Velagic, V., additional, Lovric, D., additional, Samardzic, J., additional, Ferek-Petric, B., additional, Milicic, D., additional, Biocina, B., additional, Kjaergaard, J., additional, Ghio, S., additional, St John Sutton, M., additional, Moreau, O., additional, Kervio, G., additional, Thebault, C., additional, Leclercq, C., additional, Donal, E., additional, Mornos, C., additional, Rusinaru, D., additional, Petrescu, L., additional, Cozma, D., additional, Ionac, A., additional, Pescariu, S., additional, Dragulescu, S. I., additional, Petrovic, M. Z., additional, Vujisic-Tesic, B., additional, Milasinovic, G., additional, Petrovic, M. T., additional, Nedeljkovic, I., additional, Zamaklar-Trifunovic, D., additional, Calovic, Z., additional, Jelic, V., additional, Boricic, M., additional, Petrovic, I., additional, Kuchynka, P., additional, Palecek, T., additional, Simek, S., additional, Nemecek, E., additional, Horak, J., additional, Hulinska, D., additional, Schramlova, J., additional, Vitkova, I., additional, Aster, V., additional, Linhart, A., additional, Paluszkiewicz, L., additional, Guersoy, D., additional, Ozegowski, S., additional, Spiliopoulos, S., additional, Koerfer, R., additional, Tenderich, G., additional, Gaggl, M., additional, Heinze, G., additional, Sunder-Plassmann, G., additional, Graf, S., additional, Zehetmayer, M., additional, Voigtlaender, T., additional, Mannhalter, C., additional, Paschke, E., additional, Fauler, G., additional, Mundigler, G., additional, Tesic, M., additional, Trifunovic, D., additional, Djordjevic-Dikic, A., additional, Petrovic, O., additional, Petrovic, M., additional, Beleslin, B., additional, Ostojic, M., additional, Draganic, G., additional, Correia, C. E., additional, Rodrigues, B., additional, Santos, L. F., additional, Moreira, D., additional, Gama, P., additional, Nunes, L., additional, Nascimento, C., additional, Dionisio, O., additional, Santos, O., additional, Prinz, C., additional, Oldenburg, O., additional, Bitter, T., additional, Piper, C., additional, Horstkotte, D., additional, Faber, L., additional, Nemes, A., additional, Gavaller, H., additional, Csanady, M., additional, Forster, T., additional, Calcagnino, M., additional, O'mahony, C., additional, Tsovolas, K., additional, Lambiase, P. D., additional, Elliott, P., additional, Olezac, A. S., additional, Bensaid, A., additional, Nahum, J., additional, Teiger, E., additional, Dubois-Rande, J. L., additional, Gueret, P., additional, Lim, P., additional, Langer, C., additional, Kansal, M., additional, Surapaneni, P., additional, Sengupta, P. P., additional, Lester, S. J., additional, Ommen, S. R., additional, Ressler, S. W., additional, Hurst, R. T., additional, Monivas Palomero, V., additional, Mingo Santos, S., additional, Mitroi, C., additional, Garcia Lunar, I., additional, Garcia Pavia, P., additional, Gonzalez Mirelis, J., additional, Ruiz Bautista, L., additional, Castro Urda, V., additional, Toquero Ramos, J., additional, Fernandez Lozano, I., additional, Sommer, A., additional, Poulsen, S. H., additional, Mogensen, J., additional, Thuesen, L., additional, Egeblad, H., additional, Montisci, R., additional, Ruscazio, M., additional, Vacca, A., additional, Garau, P., additional, Tuveri, F., additional, Soro, C., additional, Matthieu, A., additional, Meloni, L., additional, Kosmala, W., additional, Przewlocka-Kosmala, M., additional, Wojnalowicz, A., additional, Mysiak, A., additional, Marwick, T. H., additional, Yotti, R., additional, Ripoll, C., additional, Bermejo, J., additional, Benito, Y., additional, Mombiela, T., additional, Rincon, D., additional, Barrio, A., additional, Banares, R., additional, Fernandez-Aviles, F., additional, Tomaszewski, A., additional, Kutarski, A., additional, Tomaszewski, M., additional, Ticulescu, R., additional, Vriz, O., additional, Sparacino, L., additional, Popescu, B. A., additional, Ginghina, C., additional, Nicolosi, G. L., additional, Carerj, S., additional, Antonini-Canterin, F., additional, Agricola, E., additional, Bertoglio, L., additional, Melissano, G., additional, Chiesa, R., additional, Garcia Blas, S., additional, Iglesias Del Valle, D., additional, Lopez Fernandez, T., additional, Gomez De Diego, J. J., additional, Monedero Martin, M. C., additional, Dominguez, F. J., additional, Moreno Yanguela, M., additional, Lopez Sendon, J. L., additional, Adhya, S., additional, Murgatroyd, F. D., additional, Monaghan, M., additional, Spinarova, L., additional, Meluzin, J., additional, Hude, P., additional, Krejci, J., additional, Podrouzkova, H., additional, Pesl, M., additional, Panovsky, R., additional, Dusek, L., additional, Orban, M., additional, Korinek, J., additional, Hammerstingl, C., additional, Schwiekendik, M., additional, Nickenig, G., additional, Momcilovic, D., additional, Lickfett, L., additional, Beladan, C. C., additional, Calin, A., additional, Rosca, M., additional, Muraru, D., additional, Voinea, F., additional, Popa, E., additional, Matei, F., additional, Curea, F., additional, Di Salvo, G., additional, Pacileo, G., additional, Gala, S., additional, Castaldi, B., additional, D'aiello, A. F., additional, Mormile, A., additional, Baldini, L., additional, Russo, M. G., additional, Calabro, R., additional, Halvorsen, P. S., additional, Dahle, G., additional, Bugge, J. F., additional, Bendz, B., additional, Aaberge, L., additional, Rein, K. A., additional, Fiane, A., additional, Bergsland, J., additional, Fosse, E., additional, Aakhus, S., additional, Koopman, L. P., additional, Chahal, N., additional, Slorach, C., additional, Hui, W., additional, Sarkola, T., additional, Manlhiot, C., additional, Bradley, T. J., additional, Jaeggi, E. T., additional, Mccrindle, B. W., additional, Mertens, L., additional, D'aiello, F. A., additional, Mormilw, A., additional, Rea, A., additional, O'Connor, K., additional, Romano, G., additional, Magne, J., additional, Pierard, L., additional, Lancellotti, P., additional, Arita, T., additional, Ando, K., additional, Isotani, A., additional, Soga, Y., additional, Iwabuchi, M., additional, Nobuyoshi, M., additional, Wiesen, M., additional, Skowasch, D., additional, Breunig, F., additional, Beer, M., additional, Hu, K., additional, Wanner, C., additional, Morel, M. A., additional, Bernard, Y. F., additional, Descotes-Genon, V., additional, Meneveau, N., additional, Schiele, F., additional, Vitarelli, A., additional, Bernardi, M., additional, Scarno, A., additional, Caranci, F., additional, Padella, V., additional, Dettori, O., additional, Capotosto, L., additional, Vitarelli, M., additional, De Cicco, V., additional, Bruno, P., additional, Bajraktari, G., additional, Lindqvist, P., additional, Gustafsson, U., additional, Holmgren, A., additional, Hassan, M., additional, Said, K., additional, Baligh, E., additional, Farouk, H., additional, Osama, D., additional, Elmahdy, M. F., additional, Elfaramawy, A., additional, Sorour, K., additional, Luckie, M., additional, Zaidi, A., additional, Fitzpatrick, A., additional, Khattar, R. S., additional, Schwartz, J., additional, Huttin, O., additional, Popovic, B., additional, Zinzius, P. Y., additional, Christophe, C., additional, Marcon, O., additional, Groben, L., additional, Juilliere, Y., additional, Chabot, F., additional, Selton-Suty, C., additional, Krastev, B., additional, Kinova, E. T. K., additional, Zlatareva, N. I. Z., additional, Goudev, A. R. G., additional, Teske, A. J., additional, De Boeck, B. W., additional, Mohames Hoesein, F. A., additional, Van Driel, V., additional, Loh, P., additional, Cramer, M. J., additional, Doevendans, P. A., additional, Dillenburg, F., additional, Abd El Salam, K. M., additional, Ho, E. M. M., additional, Hall, M., additional, Hemeryck, L., additional, Bennett, K., additional, Scott, K., additional, King, G., additional, Murphy, R. T., additional, Mahmud, A., additional, Brown, A. S., additional, Dalen, H., additional, Thorstensen, A., additional, Romundstad, P. R., additional, Aase, S. A., additional, Stoylen, A., additional, Vatten, L., additional, Bochenek, T., additional, Wita, K., additional, Tabor, Z., additional, Doruchowska, A., additional, Lelek, M., additional, Trusz-Gluza, M., additional, Hamodraka, E., additional, Paraskevaidis, I., additional, Karamanou, A., additional, Michalakeas, C., additional, Vrettou, H., additional, Kapsali, E., additional, Tsiapras, D., additional, Lekakis, I., additional, Anastasiou-Nana, M., additional, Kremastinos, D., additional, Sirugo, L., additional, Bottari, V. E., additional, Licciardi, S., additional, Blundo, A., additional, Atanasio, A., additional, Monte, I. P., additional, Park, C. S., additional, Kim, J. H., additional, Cho, J. S., additional, Kim, M. J., additional, Cho, E. J., additional, Ihm, S. H., additional, Jung, H. O., additional, Jeon, H. K., additional, Youn, H. J., additional, Kim, K. S., additional, Fontana, A., additional, Taravella, L., additional, Zambon, A., additional, Trocino, G., additional, Giannattasio, C., additional, Kalinin, A., additional, Alekhin, M., additional, Bahs, G., additional, Lejnieks, A., additional, Kalvelis, A., additional, Kalnins, A., additional, Shipachovs, P., additional, Zakharova, E., additional, Blumentale, G., additional, Trukshina, M., additional, Biering-Sorensen, T., additional, Mogelvang, R., additional, Haahr-Pedersen, S., additional, Schnohr, P., additional, Sogaard, P., additional, Skov Jensen, J., additional, Gargani, L., additional, Agoston, G., additional, Capati, E., additional, Badano, L., additional, Moreo, A., additional, Costantino, M. F., additional, Caputo, M. L., additional, Mondillo, S., additional, Sicari, R., additional, Picano, E., additional, Malev, E. G., additional, Timofeev, E. V., additional, Reeva, S. V., additional, Zemtsovsky, E. V., additional, Piazza, R., additional, Enache, R., additional, Roman-Pognuz, A., additional, Leiballi, E., additional, Pecoraro, R., additional, Sadeghian, H., additional, Lotfi_Tokaldany, M., additional, Rezvanfard, M., additional, Kasemisaeid, A., additional, Majidi, S., additional, Montazeri, M., additional, Saber-Ayad, M., additional, Nassar, Y. S., additional, Farhan, A., additional, Moussa, A., additional, El-Sherif, A., additional, Cooper, R. M., additional, Somauroo, J. D., additional, Shave, R. E., additional, Williams, K. L., additional, Forster, J., additional, George, C., additional, Bett, T., additional, Gaze, D. C., additional, George, K. P., additional, Mansencal, N., additional, Dupland, A., additional, Caille, V., additional, Perrot, S., additional, Bouferrache, K., additional, Vieillard-Baron, A., additional, Jouffroy, R., additional, Cioroiu, S. G., additional, Alexe, O. S., additional, Bobescu, E., additional, Rus, H., additional, Schiano Lomoriello, V., additional, Esposito, R., additional, Santoro, A., additional, Raia, R., additional, Farina, F., additional, Ippolito, R., additional, Galderisi, M., additional, Aburawi, E. H., additional, Malcus, P., additional, Thuring, A., additional, Maxedius, A., additional, Pesonen, E., additional, Nair, S. V., additional, Joyce, E., additional, Lee, L., additional, Shrimpton, J., additional, Newman, E., additional, James, P. R., additional, Jurcut, C., additional, Caraiola, S., additional, Jurcut, R. O., additional, Giusca, S., additional, Nitescu, D., additional, Amzulescu, M. S., additional, Copaci, I., additional, Tanasescu, C., additional, Silva Marques, J., additional, Silva, D., additional, Ferreira, F., additional, Ferreira, P. C., additional, Almeida, A. G., additional, Martim Martins, J., additional, Lopes, M. G., additional, Bergenzaun, L., additional, Chew, M., additional, Ersson, A., additional, Gudmundsson, P., additional, Ohlin, H., additional, Borowiec, A., additional, Dabrowski, R., additional, Wozniak, J., additional, Jasek, S., additional, Chwyczko, T., additional, Kowalik, I., additional, Musiej-Nowakowska, E., additional, Szwed, H., additional, Wen, Y. L., additional, Tian, J., additional, Yan, L., additional, Cheng, H., additional, Yang, H., additional, Luo, B., additional, Wang, J., additional, Kozman, H., additional, Villarreal, D., additional, Liu, K., additional, Karavidas, A., additional, Tsiachris, D., additional, Lazaros, G., additional, Matzaraki, V., additional, Xylomenos, G., additional, Levendopoulos, G., additional, Arapi, S., additional, Perpinia, A., additional, Matsakas, E., additional, Pyrgakis, V., additional, Liu, Y. W., additional, Su, C. T., additional, Tsai, W. C., additional, Huang, J. W., additional, Hung, K. Y., additional, Chen, J. H., additional, Larsson, M., additional, Kremer, F., additional, Kouznetsova, T., additional, Bjallmark, A., additional, Lind, B., additional, Brodin, L.-A., additional, D'hooge, J., additional, Caputo, M., additional, Antonelli, G., additional, Lisi, M., additional, Giacomin, E., additional, Moustafa, S., additional, Alharthi, M., additional, Deng, Y., additional, Chandrasekaran, K., additional, Mookadam, F., additional, Hayashi, S. Y., additional, Nascimento, M. M., additional, Lindholm, B., additional, Seeberger, A., additional, Nowak, J., additional, Riella, M. C., additional, Brodin, L. A., additional, Theodosis, A., additional, Fousteris, E., additional, Tsiaousis, G., additional, Krommydas, A., additional, Margetis, P., additional, Katidis, Z., additional, Beldekos, D., additional, Argirakis, S., additional, Melidonis, A., additional, Foussas, S., additional, Khaleva, O., additional, Onyshchenko, O., additional, Lukaschuk, E., additional, Sherwi, N., additional, Nikitin, N., additional, Cleland, J. G. F., additional, Risum, N., additional, Jons, C., additional, Olsen, N. T., additional, Kronborg, M. B., additional, Jensen, M. T., additional, Fritz-Hansen, T., additional, Bruun, N. E., additional, Hojgaard, M. V., additional, Petrini, J., additional, Yousry, M., additional, Rickenlund, A., additional, Liska, J., additional, Franco-Cereceda, A., additional, Hamsten, A., additional, Eriksson, P., additional, Caidahl, K., additional, Eriksson, M. J., additional, Elmstedt, N., additional, Ferm-Widlund, K., additional, Westgren, M., additional, Szymczyk, E., additional, Kasprzak, J. D., additional, Wozniakowski, B., additional, Rotkiewicz, A., additional, Szymczyk, K., additional, Stefanczyk, L., additional, Michalski, B., additional, Lipiec, P., additional, Ring, L., additional, Eller, T., additional, Deegan, P., additional, Rusk, R., additional, Urbano Moral, J. A., additional, Arias, J. A., additional, Kuvin, J. T., additional, Patel, A. R., additional, Pandian, N. G., additional, Bellsham-Revell, H., additional, Bell, A. J., additional, Miller, O., additional, Greil, G. 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Published
2010
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28. 224 Adenosine induced perfusion defects versus dobutamine contraction abnormalities for diagnosis of myocardial ischemia: a comparative experimental study with contrast echocardiography and 2D strain

Author

Bertrand Beauvoit, P. Reant, Louis Labrousse, Karim Serri, Raymond Roudaut, Stéphane Lafitte, L. Tariosse, and P. Dos Santos

Subjects
medicine.medical_specialty, Contraction (grammar), Myocardial ischemia, business.industry, Perfusion scanning, General Medicine, Adenosine, Contrast echocardiography, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Dobutamine, Cardiology and Cardiovascular Medicine, business, Perfusion, 2d strain, medicine.drug
Published
2006
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29. 373 Circumferential, radial and longitudinal strain variations at rest and during dobutamine infusion: application of 2D strain for myocardial ischemia detection

Author

Raymond Roudaut, P. Reant, Simone Bonoron-Adèle, Karim Serri, Claude Deville, Louis Labrousse, Stéphane Lafitte, and P. Dos Santos

Subjects
medicine.medical_specialty, Myocardial ischemia, Longitudinal strain, business.industry, General Medicine, Anesthesia, Infusion Procedure, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Dobutamine, Cardiology and Cardiovascular Medicine, business, Rest (music), 2d strain, medicine.drug
Published
2006
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32. 940 Two-dimensional strain: a new tool for the detection of early systolic function abnormalities in hypertrophic cardiomyopathy

Author

Patricia Reant, Raymond Roudaut, Karim Serri, and Stéphane Lafitte

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Two dimensional strain, Hypertrophic cardiomyopathy, Cardiology, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, business, medicine.disease, Early systolic
Published
2005
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33. 350 Effects of right, left and biventricular pacing on myocardial perfusion: a contrast echocardiographic study in an ischemic experimental pig model

Author

Raymond Roudaut, P. Reant, Jacques Clementy, Stéphane Lafitte, Karim Serri, Louis Labrousse, Pierre Bordachar, and P. Dos Santos

Subjects
medicine.medical_specialty, business.industry, media_common.quotation_subject, Ischemia, Pig model, General Medicine, medicine.disease, Internal medicine, Contrast echocardiography, medicine, Cardiology, Contrast (vision), Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business, Perfusion, media_common
Published
2005
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34. 151 Improvement of left ventricular diastolic function after successful catheter ablation for lone paroxysmal atrial fibrillation

Author

Patricia Reant, V. Le Bouffos, Raymond Roudaut, Rukshen Weerasooriya, Michel Haïssaguerre, Stéphane Lafitte, and P. Jaïs

Subjects
medicine.medical_specialty, business.industry, Paroxysmal atrial fibrillation, medicine.medical_treatment, Diastole, Catheter ablation, General Medicine, Cardiac Ablation, Internal medicine, Cardiology, Medicine, Radiology, Nuclear Medicine and imaging, Diastolic function, Cardiology and Cardiovascular Medicine, business
Published
2003
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35. 970 Successful catheter ablation of chronic atrial fibrillation is associated with diastolic mechanical remodeling of the left heart

Author

P REANT, S LAFITTE, P JAIS, V LEBOUFFOS, J PERRON, R WEERASOORIYA, and R ROUDAUT

Subjects
medicine.medical_specialty, Ejection fraction, Ischemic cardiomyopathy, Contraction (grammar), business.industry, medicine.medical_treatment, Diastole, Catheter ablation, General Medicine, medicine.anatomical_structure, Postoperative risk, Ventricle, Internal medicine, medicine, Cardiology, Chronic atrial fibrillation, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business
Abstract

19.2±4.8 36±6.7 p

Published
2003
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36. Effects of surgery on ischaemic mitral regurgitation: a prospective multicentre registry (SIMRAM registry)

Author

Lancellotti P, Donal E, Cosyns B, Van Camp G, Monin J, Brochet E, Berrebi A, Pibarot P, Chauvel C, Hassager C, Tumminello G, Tribouilloy C, Lafitte S, Fraser AG, Derumeaux G, Athanassopoulos G, Bax J, and Piérard LA

Abstract

AIMS: Functional ischaemic mitral regurgitation (IMR) is common in patients with ischaemic left ventricular dysfunction undergoing coronary artery bypass surgery. Although the presence of IMR negatively affects prognosis, the additional benefit of valve repair is debated, particularly with mild IMR at rest. Exercise echocardiography may help identify a subset of patients at higher risk of cardiovascular events by revealing the dynamic component of IMR. METHODS: A large prospective, multicentre, non-randomized registry is designed to evaluate the effects of surgery on IMR at rest and on its dynamic component at exercise (z). SIMRAM will enrol approximately 550 patients with IMR in up to 17 centres with clinical and exercise follow-up for 1 year. Three sets of outcomes will be prospectively assessed and several hypotheses will be tested including determinants of adverse outcome and progressive left ventricular remodeling, efficacy of treatment and role of ischaemia on the dynamic consequences of IMR. Enrolment began in November 2006 and is expected to end by early 2008. [ABSTRACT FROM AUTHOR]

Published
2008
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37. Abstracts

Author

Treibel, Thomas A., Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Sayeed, Aatif, Maanja, Maren, Daya, Hussein Abu, Moon, James C., Wong, Timothy C., Schelbert, Erik B., Duca, Franz, Kammerlander, Andreas A., Zotter-Tufaro, Caroline, Aschauer, Stefan, Bonderman, Diana, Mascherbauer, Julia, Schwitter, Juerg, Beigelman-Aubry, Catherine, Peguret, Nicolas, Stuber, Matthias, Delacoste, Jean, Belmondo, Bastien, Lovis, Alban, Simons, Julien, Long, Olivier, Grant, Kathleen, Berchier, Gregoire, Rohner, Chantal, Bonanno, Gabriele, Coppo, Simone, Ozsahin, Esat-Mahmut, Qanadli, Salah, Meuli, Reto, Bourhis, Jean, Ide, Seiko, Riesenkampff, Eugenie, Chiasson, David, Dipchand, Anne I., Kantor, Paul F., Chaturvedi, Rajiv R., Yoo, Shi-Joon, Grosse-Wortmann, Lars, Sandrini, C., Aquaro, GD, De Marchi, D, Ait Ali, L, Khraiche, D, Boddaert, N, Bonnet, D, Raimondi, F, Fridman, Yaron, Hackman, Brianne E., Kadakkal, Ajay, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Angela, Susana, Alberto, Cipriani, Manuel, De Lazzari, Federico, Marin, Francesca, Prevedello, Bendetta, Giorgi, Giorgio, De Conti, Giuseppe, Tarantini, Luisa, Cacciavillani, Emanuele, Bertaglia, Domenico, Corrado, Sabino, Iliceto, Martina, Perazzolo Marra, Camaioni, Claudia, Morlon, Lucas, Vergé, Marie-Philippe, Jais, Pierre, Roudaut, Raymond, Laurent, Francois, Lafitte, Stéphane, Cochet, Hubert, Réant, Patricia, Bohnen, S., Radunski, U. K., Lund, G. K., Senel, M., Avanesov, M., Tahir, E., Stehning, C., Adam, G., Blankenberg, S., Muellerleile, K., Khanji, Mohammed Y., Balawon, Armida, Boubertakh, Redha, Petersen, Steffen E, Hilbert, Sebastian, Spampinato, Ricardo, Oebel, Sabrina, Hindricks, Gerhard, Bollmann, Andreas, Jahnke, Cosima, Paetsch, Ingo, Goetschalckx, K., Bogaert, J., Desmet, W., Toth, A., Merkely, B., Janssens, S., Claus, P., Calvieri, C., Preda, M. B., Perfetti, A., Valaperta, R., Secchi, F., Fedele, F., Martelli, F., Lombardi, M., Reinstadler, Sebastian J., Eitel, Charlotte, Fuernau, Georg, de Waha, Suzanne, Desch, Steffen, Mende, Meinhard, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Maestrini, Viviana, Mun, Hong Cheang, Kotwinski, Paul, Rosmini, Stefania, Sanders, Julie, Lloyd, Guy, Dudley, J. Pennell, Kellman, Peter, Hugh, E. Montgomery, Manisty, Charlotte, James, C. Moon, James, S., Waterhouse, D.F., Murphy, T.M., Kenny, C., O'Hanlon, R., Bastiaenen, Rachel, Cox, Andrew T., Wijeyeratne, Yanushi, Colbeck, Nicholas, Pakroo, Nadia, Ahmed, Hammad, Bunce, Nick, Anderson, Lisa, Prasad, Sanjay, Sharma, Sanjay, Behr, Elijah R., Reid, A. B., Miller, C., Jovanovic, A., Woolfson, P., Abidin, N., Schmitt, M., Amadu, A.M., Rodrigues, J.C.L., Dastidar, A. Ghosh, Baritussio, A., Lawton, C., Venuti, G., Meloni, G.B., Conti, M., Bucciarelli-Ducci, C., Pontone, Gianluca, Andreini, Daniele, SoLbiati, Anna, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Rota, Cristina, Guaricci, Andrea I., Pepi, Mauro, Wang, Yufei, Joannic, David, Juillion, Patrick, Delassus, P., Monnet, Aurélien, Lalande, Alain, Fontaine, Jean-Francois, Zweerink, A, Allaart, CP, Wu, L, Kuijer, JPA, Beek, AM, Croisille, P, Clarysse, P, van Rossum, AC, Nijveldt, R, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Hammond-Haley, Matthew, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Garg, P., Hassell, M, Foley, J., Ripley, D.P., Dobson, L., Swoboda, P.P., Fent, G., Musa, T.A., Erhayiem, B., Haaf, P., Greenwood, J.P., Nijveldt, R., Westenberg, J.J.M., Geest, R.J.V.D., Plein, S., Rodrigues, Jonathan C L, Amadu, Antonio Matteo, Dastidar, Amardeep Ghosh, Szantho, Gergley, Lyen, Stephen, Godsave, Cattleya, Ratcliffe, Laura E K, Burchell, Amy E, Hart, Emma C, Hamilton, Mark C K, Nightingale, Angus K, Paton, Julian F R, Manghat, Nathan E, Bucciarelli-Ducci, Chiara, Hafyane, Tarik, Teixeira, Tiago, Greiser, Andreas, Mongeon, Francois Pierre, Haifa, Almutairi, Mohammed, Khanji, Redha, Boubertakh, Marc, Miquel, Steffen, Petersen, Greulich, S., Kitterer, D., Latus, J., Henes, J., Kurmann, R., Gloekler, S., Wahl, A., Buss, S., Katus, H., Bobbo, M., Lombardi, M., Braun, N., Alscher, M.D., Sechtem, U., Mahrholdt, H., Meloni, A., Neri, M.G., Preziosi, P., Grassedonio, E., Schicchi, N., Keilberg, P., Pulini, S., Facchini, E., Positano, V., Pepe, A., Nazir, Sheraz A., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Squire, Iain, Gershlick, Anthony, McCann, Gerry P., Stefan Biesbroek, P., Amier, Raquel P., Teunissen, Paul F.A., Robbers, Lourens F.H.J., Beek, Aernout M., van Rossum, Albert C., Hofman, Mark B.M., van Royen, Niels, Nijveldt, Robin, Arenja, Nisha, Riffel, Johannes H, Djiokou, Charly Noel, Andre, Florian, Fritz, Thomas, Halder, Manuel, Thomas, Zelniker, Korosoglou, Grigorios, Katus, Hugo A, Buss, Sebastian J, Kammerlander, Andreas A., Schwaiger, Marianne L., Duca, Franz, Aschauer, Stefan, Marzluf, Beatrice A., Zotter-Tufaro, Caroline, Dalos, Daniel, Pfaffenberger, Stefan, Bonderman, Diana, Mascherbauer, Julia, Sayeed, Aatif, Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Maanja, Maren, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Ricci, F., Barison, A., Todiere, G., Gaeta, R., Galllina, S., Emdin, M., De Caterina, R., Aquaro, G.D., Bernhardt, Peter, Buckert, Dominik, Dyckmanns, Nils, Rottbauer, Wolfgang, Meierhofer, Christian, Kühn, Andreas, Shehu, Nerejda, Müller, Jan, Stern, Heiko, Ewert, Peter, Fratz, Sohrab, Vogt, Manfred, Devos, Daniel G.H., De Groote, Katya, Babin, Danilo, Demulier, Laurent, Taeymans, Yves, Westenberg, Jos J., Van Bortel, Luc, Segers, Patrick, Achten, Eric, De Schepper, Jean, Rietzschel, Ernst, Ruecker, Beate, Geiger, Julia, Makki, Malek, Burkhardt, Barbara, Kellenberger, Christian J., Buechel, Emanuela R. Valsangiacomo, Burkhardt, B.E.U., Kellenberger, C.J., Geiger, J., Ruecker, B., Buechel, E.R. Valsangiacomo, Kamphuis, Vivian P., Elbaz, Mohammed S.M., Kroft, Lucia J.M., van der Geest, Rob J., de Roos, Albert, Blom, Nico A., Westenberg, Jos J.M., Roest, Arno A.W., De Lazzari, Manuel, Cipriani, Alberto, Susana, Angela, Rizzo, Stefania, Giorgi, Benedetta, Carmelo, Lacognata, Bertaglia, Emanuele, Bauce, Barbara, Corrado, Domenico, Thiene, Gaetano, Marra, Martina Perazzolo, Basso, Cristina, Iliceto, Sabino, Nederend, I., Roest, A.A.W., van den Boogaard, P.J., ten Harkel, A.D.J., de Geus, J.C.N., Kroft, L.J.M., de Roos, A., Westenberg, J.J.M., Dux-Santoy, Lydia, Kale, Raquel, Teixido-Tura, Gisela, Maldonado, Giuliana, Huguet, Marina, Garcia-Dorado, David, Evangelista, Artur, Rodriguez-Palomares, Jose, Cavalcante, João L., Rijal, Shasank, Schindler, John T., Gleason, Thomas G., Lee, Joon S., Schelbert, Erik B., Rosmini, Stefania, Bulluck, Heerajnarain, Treibel, Thomas A, Bhuva, Anish, Abdel-Gadir, Amna, Culotta, Veronica, Merghani, Ahmed, Maestrini, Viviana, Herrey, Anna S, Kellman, Peter, Manisty, Charlotte, Moon, James C, Liu, B., Hayer, M.K., Baig, S., Shah, T., Rooney, S.J., Edwards, N.C., Steeds, R.P., Fent, G.J., Garg, P., Swoboda, P., Dobson, L.E., Musa, T.A., Foley, J.F., Haaf, P., Greenwood, J.P., Plein, S., Claessen, G., Schnell, F., Bogaert, J., Dymarkowski, S., Pattyn, N., Claus, P., Van Cleemput, J., Gerche, A. La, Heidbuchel, H., Behar, Jonathan, Toth, Daniel, Reiml, Sabrina, Panayiotou, Maria, Claridge, Simon, Jackson, Tom, Sohal, Manav, Webb, Jessica, O'Neill, Mark, Brost, Alexander, Mountney, Peter, Razavi, Reza, Rhode, Kawal, Rinaldi, Christopher Aldo, Oebel, S., Arya, A., Hilbert, S., Bollmann, A., Hindricks, G., Jahnke, C., Paetsch, I., Dinov, B., Baritussio, A., Perazzolo Marra, M., Ghosh Dastidar, A., Rodrigues, J., Zorzi, A., Susana, A., Scatteia, A., De Garate, E., Mattesi, G., Strange, J., Corrado, D., Bucciarelli-Ducci, C., Ranjit Arnold, J., Jerosch-Herold, Michael, Karamitsos, Theodoros D., Francis, Jane M., Bhamra-Ariza, Paul, Sarwar, Rizwan, Choudhury, Robin, Selvanayagam, Joseph B., Neubauer, Stefan, Tayal, Upasana, Scott, Andrew D, Wage, Rick, Ferreira, Pedro, Pennell, Dudley, Zhong, Xiaodong, Epstein, Fred, Firmin, David, Prasad, Sanjay, Kallifatidis, Alexandros, Prousalis, Anastasios, Mouratoglou, Sophia-Anastasia, Giannakoulas, George, Deligianni, Xenia, Bakaloudis, Michail, Magganaris, Nikolaos, Sianos, George, Karvounis, Haralampos, Santini, Francesco, Garg, P., Aziz, R., Foley, J.R.J., Fent, G., Musa, T.A., Haaf, P., Dobson, L., Swoboda, P.P., Greenwood, J.P., Plein, S., Geest, R.J.V.D., Westenberg, J.J.M., Beitzke, D., Rasul, S., Wadsak, W., Mitterhauser, M., Nolz, R., Stelzmueller, M., Loewe, C., Hacker, M., Funk, Stephanie, Kermer, Josephine, Dogangüzel, Serkan, von Knobelsdorff-Brenkenhoff, Florian, Schulz-Menger, Jeanette, Kolker, Shimon, Weisz, Giora, Bogot, Naama, Halpern, Irit Hadas, Wolak, Arik, Rutz, Tobias, Ginami, Giulia, Piccini, Davide, Coppo, Simone, Vincenti, Gabriella, Stuber, Matthias, Schwitter, Jürg, Safdar, Komal S, Gao, Xuexin, Ambach, Stephanie, Taylor, Michal D, Moore, Ryan, Taylor, Robin J, Toro-Salazar, Olga, Jeffries, John L, Bartone, Cheryl, Raman, Subha V, Mazur, Wojciech, Valente, F., Rodriguez-Palomares, J.F., Gutierrez, L., Pineda, V., Agliano, B., Galian, L., Teixido, G., Gonzalez-Alujas, M.T., Evangelista, A., Garcia-Dorado, D., Murdoch, R., Gandy, S., Nicholas, R., Houston, G., Martin, P., Muir, J., Matthew, S., Ramkumar, P. Guntur-, Cavin, I., Macaione, F., Barison, A., Pescetelli, I., Pali, F., Pizzino, F., Terrizzi, A., Di Lisi, D., Novo, G., Todiere, G., Assennato, P., Novo, S., Aquaro, G.D., Dastidar, Amardeep Ghosh, McAlindon, Elisa, Rodrigues, Jonathan, Baritussio, Anna, Scatteia, Alessandra, De Garate, Estefania, Benny Lawton, Chris, Erdei, Tamas, Szantho, Gergely, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Pontone, Gianluca, Andreini, Daniele, Rota, Cristina, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Solbiati, Anna, Guaricci, Andrea I., Pepi, Mauro, Grigoratos, Chrysanthos, Bratis, Konstantinos, Henningson, Markus, Dell'Omodarme, Matteo, Puntmann, Valentina O., Nagel, Eike, Meloni, Antonella, Giunta, Nicola, Giuliano, Pietro, Neri, Maria Giovanna, Restaino, Gennaro, Renne, Stefania, Quota, Alessandra, Positano, Vincenzo, De Marchi, Daniele, Pepe, Alessia, Pedrotti, Patrizia, Campadello, Paola, Masciocco, Gabriella, Facchetti, Rita, Milazzo, Angela, Quattrocchi, Giuseppina, Giannattasio, Cristina, Frigerio, Maria, Roghi, Alberto, Rimoldi, Ornella, De Garate, Estefania, Ghosh Dastidar, Amardeep, Baritussio, Anna, Scatteia, Alessandra, Amadu, Antonio, Venuti, Giuseppe, Rodrigues, Jonathan C., Bucciarelli-Ducci, Chiara, Careri, Giulia, Castelvecchio, Serenella, Camporeale, Antonia, Secchi, Francesco, Menicanti, Lorenzo, Lombardi, Massimo, Kockova, R., Sedlacek, K., Wichterle, D., Sikula, V., Tintera, J., Sukupova, L., Kautznerova, D., Segetova, M., Praveckova, A., Langova, R., Kryze, L., El-Husseini, W., Kautzner, J., Oebel, S., Dinov, B., Arya, A., Hilbert, S., Sommer, P., Bollmann, A., Hindricks, G., Paetsch, I., Jahnke, C., Nazir, Sheraz A., Greenwood, John P., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Gershlick, Anthony, McCann, Gerry P., Grigoratos, Chrysanthos, Liga, Riccardo, Bennatti, Elena, Barison, Andrea, Todiere, Giancarlo, Aquaro, Giovanni Donato, Dell'Omodarme, Matteo, Lombardi, Massimo, Emdin, Michele, Masci, Pier Giorgio, Barison, A, Ortalda, A, Todiere, G, Grigoratos, C, Vergaro, G, Mirizzi, G, Martini, N, De Marchi, D, Keilberg, P, Passino, C, Aquaro, GD, Emdin, M, Swoboda, Peter P, McDiarmid, Adam K, Erhayiem, Bara, Fent, Graham J, Dobson, Laura E, Garg, Pankaj, Musa, Tarique A, Foley, James R, Page, Stephen P, Greenwood, John P, Plein, Sven, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Fontana, Marianna, Ramlall, Manish, Hamarneh, Ashraf, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Broncano, J., Luna, A., Noguerol, T. Martin –, Caro, P., Toro-Cebada, R., Gonzalez, J. 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Alonso, Gómez, A. González, Hinojar, R., Golfín, C. Fernández, Esteban, A., del Castillo, A. Marco, Monteagudo, J., Izco, M. Pascual, Megías, A., Martín, A. García, Nacher, JJ. Jiménez, Zamorano, JL, Dastidar, Amardeep Ghosh, Carpenter, Alexander, Rodrigues, Jonathan, Palazzuoli, Alberto, Wilson, Catherine, Kestenbaum, Samantha, Baritussio, Anna, Baumbach, Andreas, Nightingale, Angus, Bucciarelli-Ducci, Chiara, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, Szantho, Gergely, McAlindon, Elisa, Baritussio, Anna, Scatteia, Alessandra, De Garate, Estefania, Lawton, Chris Benny, Erdei, Tamas, Manghat, Nathan, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Nazir, Sheraz A., Greenwood, John P., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Gershlick, Anthony, McCann, Gerry P., Pais, João, Picarra, Bruno, Santos, Ana Rita, Guerreiro, Rui, Congo, Kisa Hyde, Carvalho, João, Neves, David, and Aguiar, José

Abstract

Objectives: Myocardial fibrosis in noninfarcted myocardium is emerging as a principal phenotype of vulnerability to adverse events such as mortality and hospitalization for heart failure (HHF), but its optimal noninvasive measurement remains uncertain despite consistently robust histologic validation data for extracellular volume fraction (ECV). We therefore compared ECV, native T1, post contrast T1, the gadolinium contrast partition coefficient (lambda), and the presence of nonischemic scar in their associations with mortality and HHF outcomes. Method: To quantify of myocardial fibrosis, we performed T1 mapping (MOLLI) in basal and mid short axis slices with cardiovascular magnetic resonance (CMR) before contrast and 12-30 minutes post contrast bolus in 1185 consecutive patients without amyloidosis, hypertrophic or stress cardiomyopathy. We assessed associations with outcomes using Kaplan-Meier plots and chi square values from univariable Cox regression models. All standard T1 mapping parameters were obtained: native and post contrast myocardial T1, the partition coefficient lambda, and ECV. ECV = (1-hematocrit) · [ΔR1myocardium]/[ΔR1bloodpool], where R1 = 1/T1 Late gadolinium enhancement imaging with phase sensitive reconstruction identified nonischemic scar. Results: Over a median of 1.7 years, 111 individuals experienced events after CMR: 55 HHF events and 74 deaths. ECV yielded better separation of Kaplan-Meier curves in a dose dependent fashion (Figure) and also stronger associations with the combined endpoint of death or HHF. The ECV chi square (77.3, p < 0.001) was at least twice as large as the Native T1 chi square (37.5, p < 0.001), the lambda chi square (34.8, p < 0.001) and nonischemic scar (chi square = 20.5, p<0.001). Post-contrast T1 was not associated with outcomes, even when adjusting further for time after contrast bolus, renal function, and patient weight (chi square <3, p >0.10). Conclusion: Analogous to histologic previously published validation data, quantitative ECV myocardial fibrosis measures associated with outcomes far stronger than other surrogate measures outcome measures such as native T1, post contrast T1 and nonischemic scar on LGE images. These data suggest that ECV is the noninvasive metric of choice to measure myocardial fibrosis. Figure. Kaplan-Meier Plots for T1 mapping parameters.

Published
2016
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38. Poster session 4: Friday 5 December 2014, 08:30-12:30 * Location: Poster area

Author

Orii, M, Tanimoto, T, Yokoyama, M, Ota, S, Kubo, T, Hirata, K, Tanaka, A, Imanishi, T, Akasaka, T, Michelsen, MM, Pena, A, Mygind, ND, Hoest, NB, Prescott, E, Abd El Dayem, SOHA, Battah, AHMED, Abd El Azzez, FATEN, Ahmed, AZZA, Fattoh, AYA, Ismail, REEM, Andjelkovic, K, Kalimanovska Ostric, D, Nedeljkovic, I, Andjelkovic, I, Rashid, HESHAM, Abuel Enien, HESHAM, Ibraheem, MAHER, work, Tissue Doppler echocardiography research, Vago, H, Toth, A, Csecs, I, Czimbalmos, CS, Suhai, F I, Kecskes, K, Becker, D, Simor, T, Merkely, B, D'ascenzi, F, Pelliccia, A, Natali, BM, Cameli, M, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Zaha, VG, Kim, GE, Su, KN, Zhang, J, Mikush, N, Ross, J, Palmeri, M, Young, LH, Tadic, M, Ilic, SI, Celic, VC, Jaimes, C, Gonzalez Mirelis, J, Gallego, M, Goirigolzarri, J, Pellegrinet, M, Poli, S, Prati, G, Vriz, O, Di Bello, V, Carerj, S, Zito, C, Mateescu, A, Popescu, BA, Antonini-Canterin, F, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Hewing, B, Theres, L, Dreger, H, Spethmann, S, Stangl, K, Baumann, G, Knebel, F, Uejima, T, Itatani, K, Nakatani, S, Lancellotti, P, Seo, Y, Zamorano, JL, Ohte, N, Takenaka, K, group, VFM international collaboration, Naar, J, Mortensen, L, Johnson, J, Winter, R, Shahgaldi, K, Manouras, A, Braunschweig, F, Stahlberg, M, Coisne, D, Al Arnaout, A-M, Tchepkou, C, Raud Raynier, P, Diakov, C, Degand, B, Christiaens, L, Barbier, P, Mirea, O, Cefalu, C, Savioli, G, Guglielmo, M, Maltagliati, A, O'neill, L, Walsh, K, Hogan, J, Manzoor, T, Ahern, B, Owens, P, Savioli, G, Guglielmo, M, Mirea, O, Cefalu, C, Barbier, P, Sengelov, M, Biering-Sorensen, T, Jorgensen, PG, Bruun, NE, Fritz-Hansen, T, Bech, J, Olsen, FJ, Sivertsen, J, Jensen, JS, Marta, L, Abecasis, J, Reis, C, Ribeiras, R, Andrade, MJ, Mendes, M, D'andrea, A, Stanziola, A, Di Palma, E, Martino, M, Lanza, M, Betancourt, V, Maglione, M, Calabro', R, Russo, MG, Bossone, E, Vogt, M O, Meierhofer, CH, Rutz, TH, Fratz, S, Ewert, P, Roehlig, CH, Kuehn, A, Storsten, P, Eriksen, M, Remme, EW, Boe, E, Smiseth, OA, Skulstad, H, Ereminiene, E, Ordiene, R, Ivanauskas, V, Vaskelyte, J, Stoskute, N, Kazakauskaite, E, Benetis, R, Marketou, M, Parthenakis, F, Kontaraki, J, Zacharis, E, Maragkoudakis, S, Logakis, J, Roufas, K, Vougia, D, Vardas, P, Dado, E, Dado, E, Knuti, G, Djamandi, J, Shota, E, Sharka, I, Saka, J, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Kurnicka, K, Domienik-Karlowicz, J, Lichodziejewska, B, Goliszek, S, Grudzka, K, Krupa, M, Dzikowska-Diduch, O, Ciurzynski, M, Pruszczyk, P, Chung, H, Kim, JY, Yoon, YW, Min, PK, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Choi, EY, Soya, OV, Kuryata, OV, Kakihara, R, Naruse, C, Inayoshi, A, El Sebaie, MAHA, Frer, ABDEL, Abdelsamie, MAGDY, Eldamanhory, AHMED, Ciampi, Q, Cortigiani, L, Simioniuc, A, Manicardi, C, Villari, B, Picano, E, Sicari, R, Ferferieva, V, Deluyker, D, Lambrichts, I, Rigo, JM, Bito, V, Kuznetsov, VA, Yaroslavskaya, EI, Krinochkin, DV, Pushkarev, GS, Gorbatenko, EA, Trzcinski, P, Michalski, BW, Lipiec, P, Szymczyk, E, Peczek, L, Nawrot, B, Chrzanowski, L, Kasprzak, JD, Todaro, MC, Zito, C, Khandheria, BK, Cusma-Piccione, M, La Carrubba, S, Antonini-Canterin, F, Di Bello, V, Oreto, G, Di Bella, G, Carerj, S, Gunyeli, E, Oliveira Da Silva, C, Sahlen, A, Manouras, A, Winter, R, Shahgaldi, K, Spampinato, RA, Tasca, M, Roche E Silva, JG, Strotdrees, E, Schloma, V, Dmitrieva, Y, Dobrovie, M, Borger, MA, Mohr, FW, Einarsen, E, Cramariuc, D, Lonnebakken, MT, Boman, K, Gohlke-Barwolf, C, Chambers, JB, Gerdts, E, Calin, A, Rosca, M, Beladan, CC, Mirescu Craciun, A, Gurzun, MM, Mateescu, A, Enache, R, Ginghina, C, Popescu, BA, Antova, E, Georgievska Ismail, LJ, Srbinovska, E, Andova, V, Peovska, I, Davceva, J, Otljanska, M, Vavulkis, M, Tsuruta, H, Kohsaka, S, Murata, M, Yasuda, R, Dan, M, Yashima, F, Inohara, T, Maekawa, Y, Hayashida, K, Fukuda, K, Migliore, R, Adaniya, ME, Barranco, MA, Miramont, G, Gonzalez, S, Tamagusuku, H, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Amano, M, Izumi, C, Miyake, M, Tamura, T, Kondo, H, Kaitani, K, Nakagawa, Y, Ghulam Ali, S, Fusini, L, Tamborini, G, Muratori, M, Gripari, P, Bottari, V, Celeste, F, Cefalu', C, Alamanni, F, Pepi, M, Obase, K, Mor-Avi, V, Weinert, L, Lang, R, Teixeira, R, Monteiro, R, Garcia, J, Ribeiro, M, Cardim, N, Goncalves, L, Miglioranza, MH, Muraru, D, Cavalli, G, Addetia, K, Cucchini, U, Mihaila, S, Tadic, M, Veronesi, F, Lang, RM, Badano, L, Galian Gay, L, Gonzalez Alujas, MT, Teixido Tura, G, Gutierrez Garcia, L, Rodriguez-Palomares, JF, Evangelista Masip, A, Conte, L, Fabiani, I, Giannini, C, La Carruba, S, De Carlo, M, Barletta, V, Petronio, AS, Di Bello, V, Mahmoud, H, Al-Ghamdi, M, Ghabashi, A, Salaun, E, Zenses, AS, Evin, M, Collart, F, Pibarot, P, Habib, G, Rieu, R, Fabregat Andres, O, Estornell Erill, J, Cubillos-Arango, A, Bochard-Villanueva, B, Chacon-Hernandez, N, Higueras-Ortega, L, Perez-Bosca, L, Paya-Serrano, R, Ridocci-Soriano, F, Cortijo-Gimeno, J, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Mrabet, K, Kamoun, S, Fennira, S, Ben Chaabene, A, Kraiem, S, Schnell, F, Betancur, J, Daudin, M, Simon, A, Lentz, PA, Tavard, F, Hernandes, A, Carre, F, Garreau, M, Donal, E, Abduch, MCD, Vieira, MLC, Antunes, M, Mathias, W, Mady, C, Arteaga, E, Alencar, AM, Tesic, M, Djordjevic-Dikic, A, Beleslin, B, Giga, V, Trifunovic, D, Petrovic, O, Jovanovic, I, Petrovic, M, Stepanovic, J, Vujisic-Tesic, B, Choi, EY, Cha, JJ, Chung, H, Kim, KH, Yoon, YW, Kim, JY, Lee, BK, Hong, BK, Rim, SJ, Kwon, HM, Bergler-Klein, J, Geier, C, Maurer, G, Gyongyosi, M, Cortes Garcia, M, Oliva, MR, Navas, MA, Orejas, M, Rabago, R, Martinez, ME, Briongos, S, Romero, AM, Rey, M, Farre, J, Ruisanchez Villar, C, Ruiz Guerrero, L, Rubio Ruiz, S, Lerena Saenz, P, Gonzalez Vilchez, FJ, Hernandez Hernandez, JL, Armesto Alonso, S, Blanco Alonso, R, Martin Duran, R, Gonzalez-Gay, MA, Novo, G, Marturana, I, Bonomo, V, Arvigo, L, Evola, V, Karfakis, G, Lo Presti, M, Verga, S, Novo, S, Petroni, R, Acitelli, A, Bencivenga, S, Cicconetti, M, Di Mauro, M, Petroni, A, Romano, S, Penco, M, Park, SM, Kim, SA, Kim, MN, Shim, WJ, Tadic, M, Majstorovic, AM, Ivanovic, BI, Celic, VC, Driessen, M M P, Meijboom, FJ, Mertens, L, Dragulescu, A, Friedberg, MK, De Stefano, F, Santoro, C, Buonauro, A, Muscariello, R, Lo Iudice, F, Ierano, P, Esposito, R, Galderisi, M, Sunbul, M, Kivrak, T, Durmus, E, Yildizeli, B, Mutlu, B, Rodrigues, AC, Daminello, E, Echenique, LS, Cordovil, A, Oliveira, W, Monaco, CH, Lira, E, Fischer, CH, Vieira, M, Morhy, S, Mignot, A, Jaussaud, J, Chevalier, L, Lafitte, S, D'ascenzi, F, Cameli, M, Curci, V, Alvino, F, Lisi, M, Focardi, M, Corrado, D, Bonifazi, M, Mondillo, S, Ikonomidis, I, Pavlidis, G, Lambadiari, V, Kousathana, F, Triantafyllidi, H, Varoudi, M, Dimitriadis, G, Lekakis, J, Cho, J S, Cho, EJ, Yoon, HJ, Ihm, SH, Lee, JH, Molnar, A A, Kovacs, A, Apor, A, Tarnoki, AD, Tarnoki, DL, Horvath, T, Maurovich-Horvat, P, Jermendy, GY, Kiss, RG, Merkely, B, Al-Habbaa, A, Petrovic-Nagorni, S, Ciric-Zdravkovic, S, Stanojevic, D, Jankovic-Tomasevic, R, Atanaskovic, V, Mitic, V, Todorovic, L, Dakic, S, Park, J S, Choi, JH, Kim, SH, Choi, JH, Kwon, YS, Jin, HY, Coppola, C, Piscopo, G, Galletta, F, Maurea, C, Esposito, E, Barbieri, A, Maurea, N, Kaldararova, M, Tittel, P, Kantorova, A, Vrsanska, V, Kollarova, E, Hraska, V, Nosal, M, Ondriska, M, Masura, J, Simkova, I, Tadeu, I, Azevedo, O, Lourenco, M, Luis, F, Lourenco, A, Planinc, i, Bagadur, G, Bijnens, B, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Milicic, D, Cikes, M, Campanale, C M, Di Maria, S, Mega, S, Nusca, A, Marullo, F, Di Sciascio, G, El Tahlawi, M, Abdallah, M, Gouda, M, Gad, MARWA, Elawady, M, Igual Munoz, B, Maceira Gonzalez Alicia, AMG, Estornell Erill, JEE, Donate Betolin, LDB, Vazquez Sanchez Alejandro, AVS, Valera Martinez, FVM, Sepulveda- Sanchez, PSS, Cervera Zamora, ACZ, Piquer Gil Marina, MPG, Montero- Argudo, AMA, Naka, KK, Evangelou, D, Lakkas, L, Kalaitzidis, R, Bechlioulis, A, Gkirdis, I, Tzeltzes, G, Nakas, G, Pappas, K, Michalis, LK, Mansencal, N, Bagate, F, Arslan, M, Siam-Tsieu, V, Deblaise, J, El Mahmoud, R, Dubourg, O, Wierzbowska-Drabik, K, Plewka, M, Kasprzak, JD, Bandera, F, Generati, G, Pellegrino, M, Alfonzetti, E, Labate, V, Villani, S, Gaeta, M, Guazzi, M, Bandera, F, Generati, G, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Grycewicz, T, Szymanska, K, Grabowicz, W, Lubinski, A, Sotaquira, M, Pepi, M, Tamborini, G, Caiani, EG, Bochard Villanueva, B, Chacon-Hernandez, N, Fabregat-Andres, O, Garcia-Gonzalez, P, Cubillos-Arango, A, De La Espriella-Juan, R, Albiach-Montanana, C, Berenguer-Jofresa, A, Perez-Bosca, JL, Paya-Serrano, R, Cheng, H-L, Huang, C-H, Wang, Y-C, Chou, W-H, Kuznetsov, VA, Melnikov, NN, Krinochkin, DV, Kolunin, GV, Enina, TN, Sierraalta, W, Le Bihan, D, Barretto, RBM, Assef, JE, Gospos, M, Buffon, M, Ramos, AIO, Garcia, A, Pinto, IMF, Souza, AGMR, Mueller, H, Reverdin, S, Ehret, G, Conti, L, Dos Santos, S, Abdel Moneim, S S, Nhola, L F, Huang, R, Kohli, M, Longenbach, S, Green, M, Villarraga, H R, Bordun, K A, Jassal, D S, Mulvagh, S L, Evangelista, A, Madeo, A, Piras, P, Giordano, F, Giura, G, Teresi, L, Gabriele, S, Re, F, Puddu, P, Torromeo, C, Suwannaphong, S, Vathesatogkit, P, See, O, Yamwong, S, Katekao, W, Sritara, P, Iliuta, L, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Weng, K-P, Lin, C-C, Hein, S, Lehmann, L, Kossack, M, Juergensen, L, Katus, HA, Hassel, D, Turrini, F, Scarlini, S, Giovanardi, P, Messora, R, Mannucci, C, Bondi, M, Olander, R, Sundholm, JKM, Ojala, TH, Andersson, S, Sarkola, T, Karolyi, M, Kocsmar, I, Raaijmakers, R, Kitslaar, PH, Horvath, T, Szilveszter, B, Merkely, B, Maurovich-Horvat, P, Heart, Center, Vascular, University, Semmelweis, Budapest, Hungary, and Group, MTA-SE Lendület Cardiovascular Imaging Research

Abstract

Purpose: Although delayed-enhancement magnetic resonance imaging (DEMRI) is essential for diagnosis of cardiac sarcoidosis (CS), the test was not available when pacemaker was implamted. Recently, MR-conditional pacemaker has become avilable and we hypothesized that this device would be useful for diagnosis and management of CS. The aim of this study was to assess the diagnostic ability of MR-conditional pacemaker about CS in patients with advanced A-V nodal block (AAVB). Methods: Twenty-seven AAVB patients (14 men, 13 women; mean age, 69 ± 11 years) who were implanted MR-conditional pacemaker were studied. DEMRI was performed 6 weeks after implantation of permanent pacemaker. In patients with positive for DE, additional examinations like echocardiography, radioisotope imaging, biopsy, and coronary computed-tomography were performed due to confirm the diagnosis of CS and exclude coronary artery disease. Results: DE was observed in 12 patients (44 %). Out of 12 patients, 2 patients were excluded for having prior myocardial infarction. Seven of 10 (70 %) patients were diagnosed of CS by the consensus criteria. Compared with non-CS group, CS group had significantly lower age (61 ± 12 years vs. 72 ± 9 years p = 0.017). There was no significant difference about sex, angiotensin-converting enzyme, brain natriuretic peptide, and left ventricular ejection fraction between 2 groups. Six patients had started corticosteroid therapy and 5 patients (83%) recovered A-V nodal conduction. Conclusion: MR-conditional pacemaker was useful for diagnosis and management of patients with AAVB caused by CS. Figure Cardiac MRI in patient with AV block

Published
2014
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39. MODERATED POSTER SESSION: Imaging in cardiomyopathies: Friday 5 December 2014, 08:30-18:00 * Location: Moderated Poster area

Author

Risum, N, Tayal, B, Fritz Hansen, T, Bruun, NE, Saba, S, Kisslo, J, Gorcsan, J, Sogaard, P, Venner, C, Selton-Suty, C, Huttin, O, Voilliot, D, Marie, PY, Aliot, E, Juilliere, Y, Tsukishiro, Y, Onishi, T, Matsuyama, S, Chimura, M, Yamada, S, Taniguchi, Y, Yasaka, Y, Kawai, H, Reant, P, Mirabel, M, Dickie, S, Rosmini, S, Demetrescu, C, Tome-Esteban, M, Moon, JC, Lafitte, S, Elliott, PM, Mckenna, W, Ozawa, K, Funabashi, N, Takaoka, H, Kobayashi, Y, Zegri Reiriz, I, Alcolado, A, Mendez, C, Sanchez, MJ, Gomez, Y, Climent, V, Ripoll, T, Montserrat, L, Gimeno, JR, Garcia-Pavia, P, Hu, K, Liu, D, Cikes, M, Stoerk, S, Kramer, B, Gaudron, PD, Ertl, G, Bijnens, B, Weidemann, F, Herrmann, S, Kagiyama, N, Okura, H, Yamada, R, Kume, T, Neishi, Y, Ohara, M, Hayashida, A, Hirohata, A, Yamamoto, K, Yoshida, K, Sade, L E, Kozan, H, Eroglu, S, Pirat, B, Sezgin, A, Aydinalp, A, Muderrisoglu, H, Agricola, E, Spoladore, R, Ballarotto, M, Fisicaro, A, Marcatti, M, Margonato, A, and Camici, PG

Abstract

Background: Recent studies have demonstrated that longitudinal septal deformation in patients with left ventricular (LV) dysfunction and left bundle branch block (LBBB) predict LV remodeling after CRT. However, the importance of septal deformation patterns for prediction of long-term survival is unknown. Methods: From 2 centers a total of 193 CRT candidates with LBBB (NYHA II-IV, EF≤35, and QRS≥120ms) underwent echocardiography before CRT. Longitudinal 2-D strain analysis in the apical four-chamber view identified four patterns based on previously defined criteria: double-peaked systolic pattern (type 1), early pre-ejection shortening peak followed by prominent systolic stretch (type 2), shortening with one systolic peak inside 70% of ejection phase (type 3) and normal septal peak timing outside early 70% (type 4) . Outcome was pre-defined as freedom from death, left ventricular assist device or heart transplantation over 4 years. Results: Thirty-six patients (19%) had early septal deformation pattern type 1, 49(25%) type 2, 44(23%) type 3 and 64(33%) pseudonormal septal contraction type 4. There were 35 deaths, 4 transplantations, and 6 left ventricular assist device implantations over 4 years. The event rate was 0.05% (2/36) for type 1, 14% (7/49) for type 2, 25% (11/44) for type 3, 39% (25/64) for type 4. Patients with type 1 and 2 patterns had a more favourable event-free survival HR 0.26, CI 0.09-0.81 (P=0.005) than type 3 HR 1.17, CI 0.06-2.2 (P=0.65). Patients with type 4 septal contraction showed poor event-free survival HR 2.8, CI 1.6-5.1 (<0.001). (Figure 1) Conclusions: In LBBB-patients, septal deformation strain patterns predict long-term survival after CRT. Pattern 1 and 2 are highly associated with long-term survival while patients with pattern 4 have a poor prognosis. Figure

Published
2014
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