1. Treatment of congenital adrenal hyperplasia in children aged 0-3 years
- Author
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Uta Neumann, Annelieke van der Linde, Ruth E Krone, Nils P Krone, Ayla Güven, Tülay Güran, Heba Elsedfy, Sukran Poyrazoglu, Feyza Darendeliler, Tania A S S Bachega, Antonio Balsamo, Sabine E Hannema, Niels Birkebaek, Ana Vieites, Ajay Thankamony, Martine Cools, Tatjana Milenkovic, Walter Bonfig, Eduardo Correa Costa, Navoda Atapattu, Liat de Vries, Guilherme Guaragna-Filho, Marta Korbonits, Klaus Mohnike, Jillian Bryce, S Faisal Ahmed, Bernard Voet, Oliver Blankenstein, Hedi L Claahsen-van der Grinten, Pediatric surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), Pediatrics, and Neumann U., Van Der Linde A., Krone R. E., Krone N. P., Guven A., Güran T., Elsedfy H., Poyrazoglu S., Darendeliler F., Bachega T. A. S. S., et al.
- Subjects
Internal Diseases ,Endokrin ve Otonom Sistemler ,Male ,ENDOCRINOLOGY & METABOLISM ,Hydrocortisone ,Endocrinology, Diabetes and Metabolism ,Endocrinology and Metabolic Diseases ,Blood Pressure ,Sağlık Bilimleri ,Endokrinoloji ,İç Hastalıkları ,Clinical Medicine (MED) ,All institutes and research themes of the Radboud University Medical Center ,Endocrinology ,SDG 3 - Good Health and Well-being ,Mineralocorticoids ,Health Sciences ,Yaşam Bilimleri ,Medicine and Health Sciences ,Humans ,Klinik Tıp (MED) ,Sodium Chloride, Dietary ,Child ,Glucocorticoids ,Retrospective Studies ,Internal Medicine Sciences ,Klinik Tıp ,Adrenal Hyperplasia, Congenital ,Endocrine and Autonomic Systems ,Life Sciences ,Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16] ,Dahili Tıp Bilimleri ,General Medicine ,CLINICAL MEDICINE ,Tıp ,Diabetes and Metabolism ,Child, Preschool ,Fludrocortisone ,Dietary Supplements ,Endokrinoloji ve Metabolizma Hastalıkları ,ENDOKRİNOLOJİ VE METABOLİZMA ,Medicine ,Endokrinoloji, Diyabet ve Metabolizma - Abstract
Objectives International guidelines recommend additional salt supplementation during infancy in classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. The influence of corticoid medication and growth has not been assessed. Aim To investigate the current use of salt supplementation, fludrocortisone (FC) and hydrocortisone (HC) dosage as well as weight, height, BMI and blood pressure (BP) in CAH children aged 0–3 years. Methods Retrospective multicentre analysis using data from the I-CAH registry. Salt-treated (ST) and non-salt-treated (NST) children were compared regarding FC and HC dosage, weight, height and BP at 0, 3, 6, 9, 12, 18, 24, 30, and 36 months. Results We analysed 2483 visits of 331 patients born after year 2000 in 13 countries (male, n = 145) with 203 ST patients (61%). NST children had significantly higher FC dosages at 1.5–4.5 months and higher HC dosages until 1.5 months of age. No differences in weight, length and BP between subgroups were observed. Children of the whole cohort showed increased BMI-SDS during the study period and about half of the reported BP readings were >P95. Conclusion In children treated with additional salt supplementation, FC and HC dosages are lower during the first months of life but without differences in weight, length and BP until 3 years of age compared to NST children. All children showed an increase in BMI-SDS and a high rate of BP readings >P95 until 3 years, indicating the start of weight gain and negative effects on blood pressure already in very early life.
- Published
- 2022