1. Circulating miR-30b levels increase during male puberty
- Author
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Kirsi Vaaralahti, Tero Varimo, Päivi J. Miettinen, Matti Hero, Yafei Wang, Taneli Raivio, HUS Children and Adolescents, STEMM - Stem Cells and Metabolism Research Program, Research Programs Unit, Centre of Excellence in Stem Cell Metabolism, Clinicum, Timo Pyry Juhani Otonkoski / Principal Investigator, Department of Physiology, Raivio Group, and Children's Hospital
- Subjects
Male ,Hypothalamo-Hypophyseal System ,medicine.medical_specialty ,Adolescent ,Hormone Replacement Therapy ,medicine.drug_class ,Ubiquitin-Protein Ligases ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Hypothalamic–pituitary–gonadal axis ,Injections, Intramuscular ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,microRNA ,Hormone replacement therapy (male-to-female) ,medicine ,Humans ,Endocrine system ,Testosterone ,Longitudinal Studies ,Gonads ,Growth Disorders ,Puberty, Delayed ,Aromatase inhibitor ,business.industry ,Letrozole ,Puberty ,General Medicine ,MicroRNAs ,3121 General medicine, internal medicine and other clinical medicine ,030220 oncology & carcinogenesis ,Drug Therapy, Combination ,business ,medicine.drug ,Hormone - Abstract
Objective The role of miRNA as endocrine regulators is emerging, and microRNA mir-30b has been reported to repress Mkrn3. However, the expression of miR-30b during male puberty has not been studied. Design and methods Circulating relative miR-30b expression was assessed in sera of 26 boys with constitutional delay of growth and puberty (CDGP), treated with low-dose testosterone (T) (n =11) or aromatase inhibitor letrozole (Lz) (n =15) for 6 months and followed up to 12 months (NCT01797718). The associations between the relative expression of miR-30b and hormonal markers of puberty were evaluated. Results During the 12 months of the study, circulating miR-30b expression increased 2.4 ± 2.5 (s.d.) fold (P = 0.008) in all boys, but this change did not correlate with corresponding changes in LH, testosterone, inhibin B, FSH, or testicular volume (P = 0.25-0.96). Lz-induced activation of the hypothalamic–pituitary–gonadal (HPG) axis was associated with more variable miR-30b responses at 3 months (P < 0.05), whereas those treated with T exhibited significant changes in relative miR-30b levels in the course the study (P < 0.01–0.05). Conclusions Circulating miR-30b expression in boys with CDGP increases in the course of puberty, and appears to be related to the activity of the HPG axis.
- Published
- 2021