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Start Over Author "Boffetta, Paolo" Journal european journal of epidemiology
29 results on '"Boffetta, Paolo"'

4. Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Leoncini, Emanuele, Edefonti, Valeria, Hashibe, Mia, Parpinel, Maria, Cadoni, Gabriella, Ferraroni, Monica, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Lee, Yuan-Chin Amy, Chuang, Shu-Chun, Decarli, Adriano, La Vecchia, Carlo, and Boccia, Stefania

Subjects
Public Health, Health Sciences, Dental/Oral and Craniofacial Disease, Nutrition, Digestive Diseases, Prevention, Rare Diseases, Cancer, Oral and gastrointestinal, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Antioxidants, Carcinoma, Squamous Cell, Carotenoids, Case-Control Studies, Epidemiologic Studies, Europe, Female, Head and Neck Neoplasms, Humans, Japan, Middle Aged, Squamous Cell Carcinoma of Head and Neck, United States, Head and neck cancer, Nutrients, Diet, Public Health and Health Services, Epidemiology
Abstract

Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case-control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39 % (95 % CI 29-47 %) for oral/pharyngeal cancer and 39 % (95 % CI 24-50 %) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18 % reduction in the rate of oral and pharyngeal cancer (95 % CI 6-29 %) and 17 % reduction in the rate of laryngeal cancer (95 % CI 0-32 %). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p

Published
2016

5. The application of six dietary scores to a Middle Eastern population : a comparative analysis of mortality in a prospective study

Author

Hashemian, Maryam, Farvid, Maryam S., Poustchi, Hossein, Murphy, Gwen, Etemadi, Arash, Hekmatdoost, Azita, Kamangar, Farin, Sheikh, Mahdi, Pourshams, Akram, Sepanlou, Sadaf G., Malekshah, Akbar Fazeltabar, Khoshnia, Masoud, Gharavi, Abdolsamad, Brennan, Paul J., Boffetta, Paolo, Dawsey, Sanford M., Reedy, Jill, Subar, Amy F., Abnet, Christian C., and Malekzadeh, Reza

Published
2019

6. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author

Leoncini, Emanuele, Ricciardi, Walter, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Paludetti, Gaetano, Brennan, Paul, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Talamini, Renato, La Vecchia, Carlo, Olshan, Andrew F, Winn, Deborah M, Herrero, Rolando, Franceschi, Silvia, Castellsague, Xavier, Muscat, Joshua, Morgenstern, Hal, Zhang, Zuo-Feng, Levi, Fabio, Dal Maso, Luigino, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L, Lazarus, Philip, Purdue, Mark P, Hayes, Richard B, Chen, Chu, Schwartz, Stephen M, Shangina, Oxana, Koifman, Sergio, Ahrens, Wolfgang, Matos, Elena, Lagiou, Pagona, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Fernandez, Leticia, Menezes, Ana, Agudo, Antonio, Daudt, Alexander W, Richiardi, Lorenzo, Kjaerheim, Kristina, Mates, Dana, Betka, Jaroslav, Yu, Guo-Pei, Schantz, Stimson, Simonato, Lorenzo, Brenner, Hermann, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Fabianova, Eleonora, Znaor, Ariana, Rudnai, Peter, Healy, Claire, Boffetta, Paolo, Chuang, Shu-Chun, Lee, Yuan-Chin Amy, Hashibe, Mia, and Boccia, Stefania

Subjects
Tobacco Smoke and Health, Clinical Research, Prevention, Tobacco, Cancer, Rare Diseases, Dental/Oral and Craniofacial Disease, Good Health and Well Being, Adult, Aged, Alcohol Drinking, Body Height, Case-Control Studies, Educational Status, Female, Head and Neck Neoplasms, Humans, Incidence, Interviews as Topic, Logistic Models, Male, Middle Aged, Odds Ratio, Overweight, Risk Factors, Smoking, Height, Consortium, Head and neck neoplasms, Public Health and Health Services, Epidemiology
Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95% CI 0.86-0.95 for men; adjusted OR = 0.86, 95% CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Published
2014

7. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium

Author

Leoncini, Emanuele, Vukovic, Vladimir, Cadoni, Gabriella, Giraldi, Luca, Pastorino, Roberta, Arzani, Dario, Petrelli, Livia, Wünsch-Filho, Victor, Toporcov, Tatiana Natasha, Moyses, Raquel Ayub, Matsuo, Keitaro, Bosetti, Cristina, La Vecchia, Carlo, Serraino, Diego, Simonato, Lorenzo, Merletti, Franco, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Boccia, Stefania

Published
2018
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11. Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium

Author

Ordóñez-Mena, José Manuel, Schöttker, Ben, Fedirko, Veronika, Jenab, Mazda, Olsen, Anja, Halkjær, Jytte, Kampman, Ellen, de Groot, Lisette, Jansen, Eugene, Bueno-de-Mesquita, H. Bas, Peeters, Petra H., Siganos, Galatios, Wilsgaard, Tom, Perna, Laura, Holleczek, Bernd, Pettersson-Kymmer, Ulrika, Orfanos, Philippos, Trichopoulou, Antonia, Boffetta, Paolo, and Brenner, Hermann

Published
2016

16. Impact of body size and physical activity during adolescence and adult life on overall and cause-specific mortality in a large cohort study from Iran

Author

Etemadi, Arash, Abnet, Christian C., Kamangar, Farin, Islami, Farhad, Khademi, Hooman, Pourshams, Akram, Poustchi, Hossein, Bagheri, Mohammad, Sohrabpour, Amir Ali, Aliasgar, Ali, Khoshnia, Masoud, Wacholder, Sholom, Matthews, Charles C., Pharoah, Paul D., Brennan, Paul, Boffetta, Paolo, Malekzadeh, Reza, and Dawsey, Sanford M.

Published
2014

17. Repeated measures of body mass index and C-reactive protein in relation to all-cause mortality and cardiovascular disease: results from the consortium on health and ageing network of cohorts in Europe and the United States (CHANCES)

Author

O'Doherty, Mark G., Jørgensen, Torben, Borglykke, Anders, Brenner, Hermann, Schöttker, Ben, Wilsgaard, Tom, Siganos, Galatios, Kavousi, Maryam, Hughes, Maria, Müezzinler, Aysel, Holleczek, Bernd, Franco, Oscar H., Hofman, Albert, Boffetta, Paolo, Trichopoulou, Antonia, and Kee, Frank

Published
2014

18. The Consortium on Health and Ageing: Network of Cohorts in Europe and the United States (CHANCES) project—design, population and data harmonization of a large-scale, international study

Author

Boffetta, Paolo, Bobak, Martin, Borsch-Supan, Axel, Brenner, Hermann, Eriksson, Sture, Grodstein, Fran, Jansen, Eugene, Jenab, Mazda, Juerges, Hendrik, Kampman, Ellen, Kee, Frank, Kuulasmaa, Kari, Park, Yikyung, Tjonneland, Anne, van Duijn, Cornelia, Wilsgaard, Tom, Wolk, Alicja, Trichopoulos, Dimitrios, Bamia, Christina, and Trichopoulou, Antonia

Published
2014

19. Risk of upper aerodigestive tract cancer and type of alcoholic beverage: a European multicenter case—control study

Author

Marron, Manuela, Boffetta, Paolo, Møller, Henrik, Ahrens, Wolfgang, Pohlabeln, Hermann, Benhamou, Simone, Bouchardy, Christine, Lagiou, Pagona, Lagiou, Areti, Slámová, Alena, Schejbalová, Miriam, Merletti, Franco, Richiardi, Lorenzo, Kjaerheim, Kristina, Agudo, Antonio, Castellsague, Xavier, Macfarlane, Tatiana Victorovna, Macfarlane, Gary John, Talamini, Renato, Barzan, Luigi, Canova, Cristina, Simonato, Lorenzo, Biggs, Anne-Marie, Thomson, Peter, Conway, David Ian, McKinney, Patricia Ann, Znaor, Ariana, Healy, Claire Marie, McCartan, Bernard Eugene, Brennan, Paul, and Hashibe, Mia

Published
2012

20. Erratum to: Recreational physical activity and risk of head and neck cancer: a pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium

Author

Nicolotti, Nicola, Chuang, Shu-Chun, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Bosetti, Cristina, Brenner, Hermann, Hosono, Satoyo, La Vecchia, Carlo, Talamini, Renato, Matsuo, Keitaro, Müller, Heiko, Muscat, Joshua, Paludetti, Gaetano, Ricciardi, Gualtiero, Boffetta, Paolo, Hashibe, Mia, and Boccia, Stefania

Published
2011

21. Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration

Author

Janssens, A. Cecile J. W., Ioannidis, John P. A., Bedrosian, Sara, Boffetta, Paolo, Dolan, Siobhan M., Dowling, Nicole, Fortier, Isabel, Freedman, Andrew N., Grimshaw, Jeremy M., Gulcher, Jeffrey, Gwinn, Marta, Hlatky, Mark A., Janes, Holly, Kraft, Peter, Melillo, Stephanie, O'Donnell, Christopher J., Pencina, Michael J., Ransohoff, David, Schully, Sheri D., Seminara, Daniela, Winn, Deborah M., Wright, Caroline F., van Duijn, Cornelia M., Little, Julian, and Khoury, Muin J.

Published
2011

22. Recreational physical activity and risk of head and neck cancer: a pooled analysis within the international head and neck cancer epidemiology (INHANCE) Consortium

Author

Nicolotti, Nicola, Chuang, Shu-Chun, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Bosetti, Cristina, Brenner, Hermann, Hosono, Satoyo, La Vecchia, Carlo, Talamini, Renato, Matsuo, Keitaro, Müller, Heiko, Muscat, Joshua, Paludetti, Gaetano, Ricciardi, Gualtiero, Boffetta, Paolo, Hashibe, Mia, and Boccia, Stefania

Published
2011

24. Effect of major lifestyle risk factors, independent and jointly, on life expectancy with and without cardiovascular disease: results from the Consortium on Health and Ageing Network of Cohorts in Europe and the United States (CHANCES)

Author

O’Doherty, Mark G., primary, Cairns, Karen, additional, O’Neill, Vikki, additional, Lamrock, Felicity, additional, Jørgensen, Torben, additional, Brenner, Hermann, additional, Schöttker, Ben, additional, Wilsgaard, Tom, additional, Siganos, Galatios, additional, Kuulasmaa, Kari, additional, Boffetta, Paolo, additional, Trichopoulou, Antonia, additional, and Kee, Frank, additional

Published
2016
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25. Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium

Author

Ordóñez-Mena, José Manuel, primary, Schöttker, Ben, additional, Fedirko, Veronika, additional, Jenab, Mazda, additional, Olsen, Anja, additional, Halkjær, Jytte, additional, Kampman, Ellen, additional, de Groot, Lisette, additional, Jansen, Eugene, additional, Bueno-de-Mesquita, H. Bas, additional, Peeters, Petra H., additional, Siganos, Galatios, additional, Wilsgaard, Tom, additional, Perna, Laura, additional, Holleczek, Bernd, additional, Pettersson-Kymmer, Ulrika, additional, Orfanos, Philippos, additional, Trichopoulou, Antonia, additional, Boffetta, Paolo, additional, and Brenner, Hermann, additional

Published
2015
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26. Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Leoncini, Emanuele, primary, Edefonti, Valeria, additional, Hashibe, Mia, additional, Parpinel, Maria, additional, Cadoni, Gabriella, additional, Ferraroni, Monica, additional, Serraino, Diego, additional, Matsuo, Keitaro, additional, Olshan, Andrew F., additional, Zevallos, Jose P., additional, Winn, Deborah M., additional, Moysich, Kirsten, additional, Zhang, Zuo-Feng, additional, Morgenstern, Hal, additional, Levi, Fabio, additional, Kelsey, Karl, additional, McClean, Michael, additional, Bosetti, Cristina, additional, Schantz, Stimson, additional, Yu, Guo-Pei, additional, Boffetta, Paolo, additional, Lee, Yuan-Chin Amy, additional, Chuang, Shu-Chun, additional, Decarli, Adriano, additional, La Vecchia, Carlo, additional, and Boccia, Stefania, additional

Published
2015
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27. Repeated measures of body mass index and C-reactive protein in relation to all-cause mortality and cardiovascular disease: results from the consortium on health and ageing network of cohorts in Europe and the United States (CHANCES)

Author

O’Doherty, Mark G., primary, Jørgensen, Torben, additional, Borglykke, Anders, additional, Brenner, Hermann, additional, Schöttker, Ben, additional, Wilsgaard, Tom, additional, Siganos, Galatios, additional, Kavousi, Maryam, additional, Hughes, Maria, additional, Müezzinler, Aysel, additional, Holleczek, Bernd, additional, Franco, Oscar H., additional, Hofman, Albert, additional, Boffetta, Paolo, additional, Trichopoulou, Antonia, additional, and Kee, Frank, additional

Published
2014
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28. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author

Leoncini, Emanuele, primary, Ricciardi, Walter, additional, Cadoni, Gabriella, additional, Arzani, Dario, additional, Petrelli, Livia, additional, Paludetti, Gaetano, additional, Brennan, Paul, additional, Luce, Daniele, additional, Stucker, Isabelle, additional, Matsuo, Keitaro, additional, Talamini, Renato, additional, La Vecchia, Carlo, additional, Olshan, Andrew F., additional, Winn, Deborah M., additional, Herrero, Rolando, additional, Franceschi, Silvia, additional, Castellsague, Xavier, additional, Muscat, Joshua, additional, Morgenstern, Hal, additional, Zhang, Zuo-Feng, additional, Levi, Fabio, additional, Dal Maso, Luigino, additional, Kelsey, Karl, additional, McClean, Michael, additional, Vaughan, Thomas L., additional, Lazarus, Philip, additional, Purdue, Mark P., additional, Hayes, Richard B., additional, Chen, Chu, additional, Schwartz, Stephen M., additional, Shangina, Oxana, additional, Koifman, Sergio, additional, Ahrens, Wolfgang, additional, Matos, Elena, additional, Lagiou, Pagona, additional, Lissowska, Jolanta, additional, Szeszenia-Dabrowska, Neonila, additional, Fernandez, Leticia, additional, Menezes, Ana, additional, Agudo, Antonio, additional, Daudt, Alexander W., additional, Richiardi, Lorenzo, additional, Kjaerheim, Kristina, additional, Mates, Dana, additional, Betka, Jaroslav, additional, Yu, Guo-Pei, additional, Schantz, Stimson, additional, Simonato, Lorenzo, additional, Brenner, Hermann, additional, Conway, David I., additional, Macfarlane, Tatiana V., additional, Thomson, Peter, additional, Fabianova, Eleonora, additional, Znaor, Ariana, additional, Rudnai, Peter, additional, Healy, Claire, additional, Boffetta, Paolo, additional, Chuang, Shu-Chun, additional, Lee, Yuan-Chin Amy, additional, Hashibe, Mia, additional, and Boccia, Stefania, additional

Published
2013
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29. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium

Author

Emanuele Leoncini, Tatiana Natasha Toporcov, Carlo La Vecchia, Lorenzo Simonato, Stefania Boccia, Keitaro Matsuo, Vladimir Vukovic, Luca Giraldi, Cristina Bosetti, Raquel Ayub Moyses, Dario Arzani, Diego Serraino, Gabriella Cadoni, Livia Petrelli, Yuan Chin Amy Lee, Franco Merletti, Victor Wünsch-Filho, Paolo Boffetta, Roberta Pastorino, Mia Hashibe, Leoncini, Emanuele, Vukovic, Vladimir, Cadoni, Gabriella, Giraldi, Luca, Pastorino, Roberta, Arzani, Dario, Petrelli, Livia, Wünsch-Filho, Victor, Toporcov, Tatiana Natasha, Moyses, Raquel Ayub, Matsuo, Keitaro, Bosetti, Cristina, la Vecchia, Carlo, Serraino, Diego, Simonato, Lorenzo, Merletti, Franco, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Boccia, Stefania

Subjects
Male, 0301 basic medicine, Larynx, Oncology, medicine.medical_specialty, Epidemiology, ESTUDOS MULTICÊNTRICOS, Kaplan-Meier Estimate, Neoplasms, Multiple Primary, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Risk Factors, Interquartile range, Recurrence, Internal medicine, Preventive, medicine, Humans, Head and neck cancer, Settore MED/42 - IGIENE GENERALE E APPLICATA, Cancer, Aged, Neoplasm Staging, business.industry, Predictors, Hazard ratio, Second primary cancer, Middle Aged, medicine.disease, Confidence interval, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Female, Settore MED/31 - OTORINOLARINGOIATRIA, Neoplasm Recurrence, Local, business, Predictor
Abstract

Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neck cancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC and clinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from five studies members of the International Head and Neck Cancer Epidemiology consortium—Milan, Rome, Western Europe, Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52–67). Multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for recurrence and SPC. During follow-up, 1161 (29%) patients had recurrence and 343 (8.6%) developed SPC. Advanced tumour stage was associated with increased risk of recurrence in HNC overall (HR = 1.76, 95% CI 1.41–2.19). Women with laryngeal cancer had a reduced risk of recurrence compared to men (HR = 0.39, 95% CI: 0.24–0.74). Concerning predictors of SPC, advanced age (HR = 1.02; 95% CI: 1.00–1.04) and alcohol consumption (> 1 drink per day, HR = 2.11; 95% CI: 1.13–3.94) increased the risk of SPC among patients with laryngeal cancer. Additionally, women were at higher risk of SPC, in HNC overall group (HR = 1.68; 95% CI: 1.13–2.51) and oropharyngeal cancer group (HR = 1.74; 95% CI: 1.02–2.98). Tumour stage and male gender (larynx only) were positive predictors of cancer recurrence in HNC patients. Predictors of SPC were advanced age and alcohol use among laryngeal cancer cases, and female gender for oropharyngeal and HNC overall.

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