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Start Over Author "Lilin She" Journal european journal of heart failure
2 results on '"Lilin She"'

1. Clinical characteristics and outcomes of patients with and without diabetes in the Surgical Treatment for Ischemic Heart Failure (STICH) trial

Author

Kerry L. Lee, George Sopko, Torsten Doenst, Christopher Adlbrecht, Mark C. Petrie, Serenella Castelvecchio, Lilin She, Philip F. Binkley, Rafal Dabrowski, Dominika Szalewska, Eric J. Velazquez, Myron A. Waclawiw, Robert E. Michler, Jean L. Rouleau, Ru San Tan, Jae K. Oh, Michael R. MacDonald, and Alan B. Miller

Subjects
medicine.medical_specialty, Ejection fraction, business.industry, Hazard ratio, Stroke volume, medicine.disease, Confidence interval, surgical procedures, operative, Internal medicine, Diabetes mellitus, Heart failure, medicine, Cardiology, cardiovascular diseases, Cardiology and Cardiovascular Medicine, Prospective cohort study, business, Surgical treatment
Abstract

The characteristics and clinical outcomes of patients with and without DM randomized to CABG and MED or MED alone were compared. DM was present in 40%. At baseline, patients with DM had more triple vessel CAD, higher LVEF, and smaller left ventricular volumes. In patients with DM, the primary outcome of all-cause mortality occurred in 39% of patients in the MED group and 39% in the CABG group [hazard ratio (HR) with CABG 0.96, 95% confidence interval (CI) 0.73–1.26]. In patients without DM, the primary outcome occurred in 41% of patients in the MED group and 32% in the CABG group (HR with CABG 0.80, 95% CI 0.63–1.02). While numerically it would appear that the treatment effect of CABG is blunted in patients with DM, there was no significant interaction between DM and treatment group on formal statistical testing.

Published
2015
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2. Clinical characteristics and outcomes of patients with and without diabetes in the Surgical Treatment for Ischemic Heart Failure (STICH) trial

Author

Michael R, MacDonald, Lilin, She, Torsten, Doenst, Philip F, Binkley, Jean L, Rouleau, Ru-San, Tan, Kerry L, Lee, Alan B, Miller, George, Sopko, Dominika, Szalewska, Myron A, Waclawiw, Rafal, Dabrowski, Serenella, Castelvecchio, Christopher, Adlbrecht, Robert E, Michler, Jae K, Oh, Eric J, Velazquez, and Mark C, Petrie

Subjects
Diabetes Complications, Heart Failure, Male, Myocardial Ischemia, Humans, Female, Stroke Volume, Prospective Studies, Coronary Artery Bypass, Middle Aged, Ventricular Function, Left, Article, Aged
Abstract

Hypothesis 1 of the Surgical Treatment for Ischemic Heart Failure (STICH) trial enrolled 1212 patients with an LVEF of ≤35% and CAD amenable to coronary artery bypass grafting (CABG). Patients were randomized to CABG and optimal medical therapy (MED) or MED alone. The objective was to assess whether or not patients with diabetes mellitus (DM) enrolled in the STICH trial would have greater benefit from CABG than patients without DM.The characteristics and clinical outcomes of patients with and without DM randomized to CABG and MED or MED alone were compared. DM was present in 40%. At baseline, patients with DM had more triple vessel CAD, higher LVEF, and smaller left ventricular volumes. In patients with DM, the primary outcome of all-cause mortality occurred in 39% of patients in the MED group and 39% in the CABG group [hazard ratio (HR) with CABG 0.96, 95% confidence interval (CI) 0.73-1.26]. In patients without DM, the primary outcome occurred in 41% of patients in the MED group and 32% in the CABG group (HR with CABG 0.80, 95% CI 0.63-1.02). While numerically it would appear that the treatment effect of CABG is blunted in patients with DM, there was no significant interaction between DM and treatment group on formal statistical testing.Patients with DM enrolled in the STICH trial had more triple vessel disease, smaller hearts, and higher LVEF than those without DM. CABG did not exert greater benefit in patients with DM.

Published
2015

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