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1. Machine learning‐based prediction of in‐hospital death for patients with takotsubo syndrome: The InterTAK‐ML model

Author

De Filippo, Ovidio, primary, Cammann, Victoria L., additional, Pancotti, Corrado, additional, Di Vece, Davide, additional, Silverio, Angelo, additional, Schweiger, Victor, additional, Niederseer, David, additional, Szawan, Konrad A., additional, Würdinger, Michael, additional, Koleva, Iva, additional, Dusi, Veronica, additional, Bellino, Michele, additional, Vecchione, Carmine, additional, Parodi, Guido, additional, Bossone, Eduardo, additional, Gili, Sebastiano, additional, Neuhaus, Michael, additional, Franke, Jennifer, additional, Meder, Benjamin, additional, Jaguszewski, Miłosz, additional, Noutsias, Michel, additional, Knorr, Maike, additional, Jansen, Thomas, additional, Dichtl, Wolfgang, additional, von Lewinski, Dirk, additional, Burgdorf, Christof, additional, Kherad, Behrouz, additional, Tschöpe, Carsten, additional, Sarcon, Annahita, additional, Shinbane, Jerold, additional, Rajan, Lawrence, additional, Michels, Guido, additional, Pfister, Roman, additional, Cuneo, Alessandro, additional, Jacobshagen, Claudius, additional, Karakas, Mahir, additional, Koenig, Wolfgang, additional, Pott, Alexander, additional, Meyer, Philippe, additional, Roffi, Marco, additional, Banning, Adrian, additional, Wolfrum, Mathias, additional, Cuculi, Florim, additional, Kobza, Richard, additional, Fischer, Thomas A., additional, Vasankari, Tuija, additional, Airaksinen, K.E. Juhani, additional, Napp, L. Christian, additional, Dworakowski, Rafal, additional, MacCarthy, Philip, additional, Kaiser, Christoph, additional, Osswald, Stefan, additional, Galiuto, Leonarda, additional, Chan, Christina, additional, Bridgman, Paul, additional, Beug, Daniel, additional, Delmas, Clément, additional, Lairez, Olivier, additional, Gilyarova, Ekaterina, additional, Shilova, Alexandra, additional, Gilyarov, Mikhail, additional, El‐Battrawy, Ibrahim, additional, Akin, Ibrahim, additional, Poledniková, Karolina, additional, Toušek, Petr, additional, Winchester, David E., additional, Massoomi, Michael, additional, Galuszka, Jan, additional, Ukena, Christian, additional, Poglajen, Gregor, additional, Carrilho‐Ferreira, Pedro, additional, Hauck, Christian, additional, Paolini, Carla, additional, Bilato, Claudio, additional, Kobayashi, Yoshio, additional, Kato, Ken, additional, Ishibashi, Iwao, additional, Himi, Toshiharu, additional, Din, Jehangir, additional, Al‐Shammari, Ali, additional, Prasad, Abhiram, additional, Rihal, Charanjit S., additional, Liu, Kan, additional, Schulze, P. Christian, additional, Bianco, Matteo, additional, Jörg, Lucas, additional, Rickli, Hans, additional, Pestana, Gonçalo, additional, Nguyen, Thanh H., additional, Böhm, Michael, additional, Maier, Lars S., additional, Pinto, Fausto J., additional, Widimský, Petr, additional, Felix, Stephan B., additional, Braun‐Dullaeus, Ruediger C., additional, Rottbauer, Wolfgang, additional, Hasenfuß, Gerd, additional, Pieske, Burkert M., additional, Schunkert, Heribert, additional, Budnik, Monika, additional, Opolski, Grzegorz, additional, Thiele, Holger, additional, Bauersachs, Johann, additional, Horowitz, John D., additional, Di Mario, Carlo, additional, Bruno, Francesco, additional, Kong, William, additional, Dalakoti, Mayank, additional, Imori, Yoichi, additional, Münzel, Thomas, additional, Crea, Filippo, additional, Lüscher, Thomas F., additional, Bax, Jeroen J., additional, Ruschitzka, Frank, additional, De Ferrari, Gaetano Maria, additional, Fariselli, Piero, additional, Ghadri, Jelena R., additional, Citro, Rodolfo, additional, D'Ascenzo, Fabrizio, additional, and Templin, Christian, additional

Published
2023
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2. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 1: overview and the central role for catecholamines and sympathetic nervous system

Author

Omerovic, Elmir, primary, Citro, Rodolfo, additional, Bossone, Eduardo, additional, Redfors, Bjorn, additional, Backs, Johannes, additional, Bruns, Bastian, additional, Ciccarelli, Michele, additional, Couch, Liam S., additional, Dawson, Dana, additional, Grassi, Guido, additional, Iacoviello, Massimo, additional, Parodi, Guido, additional, Schneider, Birke, additional, Templin, Christian, additional, Ghadri, Jelena R., additional, Thum, Thomas, additional, Chioncel, Ovidiu, additional, Tocchetti, C. Gabriele, additional, van der Velden, Jolanda, additional, Heymans, Stephane, additional, and Lyon, Alexander R., additional

Published
2022
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3. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications

Author

Omerovic, Elmir, primary, Citro, Rodolfo, additional, Bossone, Eduardo, additional, Redfors, Bjorn, additional, Backs, Johannes, additional, Bruns, Bastian, additional, Ciccarelli, Michele, additional, Couch, Liam S., additional, Dawson, Dana, additional, Grassi, Guido, additional, Iacoviello, Massimo, additional, Parodi, Guido, additional, Schneider, Birke, additional, Templin, Christian, additional, Ghadri, Jelena R., additional, Thum, Thomas, additional, Chioncel, Ovidiu, additional, Tocchetti, C. Gabriele, additional, van der Velden, Jolanda, additional, Heymans, Stephane, additional, and Lyon, Alexander R., additional

Published
2021
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4. Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 2: vascular pathophysiology, gender and sex hormones, genetics, chronic cardiovascular problems and clinical implications

Author

Omerovic, Elmir, Citro, Rodolfo, Bossone, Eduardo, Redfors, Bjorn, Backs, Johannes, Bruns, Bastian, Ciccarelli, Michele, Couch, Liam S., Dawson, Dana, Grassi, Guido, Iacoviello, Massimo, Parodi, Guido, Schneider, Birke, Templin, Christian, Ghadri, Jelena R., Thum, Thomas, Chioncel, Ovidiu, Tocchetti, C. Gabriele, van der Velden, Jolanda, and Heymans, Stephane

Subjects
GENDER, SEX hormones, GENETICS, PERIPHERAL nervous system, PLURIPOTENT stem cells, HEART failure
Abstract

While the first part of the scientific statement on the pathophysiology of Takotsubo syndrome was focused on catecholamines and the sympathetic nervous system, in the second part we focus on the vascular pathophysiology including coronary and systemic vascular responses, the role of the central and peripheral nervous systems during the acute phase and abnormalities in the subacute phase, the gender differences and integrated effects of sex hormones, genetics of Takotsubo syndrome including insights from microRNA studies and inducible pluripotent stem cell models of Takotsubo syndrome. We then discuss the chronic abnormalities of cardiovascular physiology in survivors, the limitations of current clinical and preclinical studies, the implications of the knowledge of pathophysiology for clinical management and future perspectives and directions of research. [ABSTRACT FROM AUTHOR]

Published
2022
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5. Impact of aspirin on takotsubo syndrome: a propensity score‐based analysis of the InterTAK Registry

Author

D'Ascenzo, Fabrizio, primary, Gili, Sebastiano, additional, Bertaina, Maurizio, additional, Iannaccone, Mario, additional, Cammann, Victoria L., additional, Di Vece, Davide, additional, Kato, Ken, additional, Saglietto, Andrea, additional, Szawan, Konrad A., additional, Frangieh, Antonio H., additional, Boffini, Beatrice, additional, Annaratone, Margherita, additional, Sarcon, Annahita, additional, Levinson, Rena A., additional, Franke, Jennifer, additional, Napp, L. Christian, additional, Jaguszewski, Milosz, additional, Noutsias, Michel, additional, Münzel, Thomas, additional, Knorr, Maike, additional, Heiner, Susanne, additional, Katus, Hugo A., additional, Burgdorf, Christof, additional, Schunkert, Heribert, additional, Thiele, Holger, additional, Bauersachs, Johann, additional, Tschöpe, Carsten, additional, Pieske, Burkert M., additional, Rajan, Lawrence, additional, Michels, Guido, additional, Pfister, Roman, additional, Cuneo, Alessandro, additional, Jacobshagen, Claudius, additional, Hasenfuß, Gerd, additional, Karakas, Mahir, additional, Koenig, Wolfgang, additional, Rottbauer, Wolfgang, additional, Said, Samir M., additional, Braun‐Dullaeus, Ruediger C., additional, Banning, Adrian, additional, Cuculi, Florim, additional, Kobza, Richard, additional, Fischer, Thomas A., additional, Vasankari, Tuija, additional, Airaksinen, K.E. Juhani, additional, Opolski, Grzegorz, additional, Dworakowski, Rafal, additional, MacCarthy, Philip, additional, Kaiser, Christoph, additional, Osswald, Stefan, additional, Galiuto, Leonarda, additional, Crea, Filippo, additional, Dichtl, Wolfgang, additional, Franz, Wolfgang M., additional, Empen, Klaus, additional, Felix, Stephan B., additional, Delmas, Clément, additional, Lairez, Olivier, additional, El‐Battrawy, Ibrahim, additional, Akin, Ibrahim, additional, Borggrefe, Martin, additional, Horowitz, John D., additional, Kozel, Martin, additional, Tousek, Petr, additional, Widimský, Petr, additional, Gilyarova, Ekaterina, additional, Shilova, Alexandra, additional, Gilyarov, Mikhail, additional, Biondi‐Zoccai, Giuseppe, additional, Winchester, David E., additional, Ukena, Christian, additional, Neuhaus, Michael, additional, Bax, Jeroen J., additional, Prasad, Abhiram, additional, Di Mario, Carlo, additional, Böhm, Michael, additional, Gasparini, Mauro, additional, Ruschitzka, Frank, additional, Bossone, Eduardo, additional, Citro, Rodolfo, additional, Rinaldi, Mauro, additional, De Ferrari, Gaetano Maria, additional, Lüscher, Thomas, additional, Ghadri, Jelena R., additional, and Templin, Christian, additional

Published
2019
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6. Prediction of short‐ and long‐term mortality in takotsubo syndrome: the InterTAK Prognostic Score

Author

Wischnewsky, Manfred B., primary, Candreva, Alessandro, additional, Bacchi, Beatrice, additional, Cammann, Victoria L., additional, Kato, Ken, additional, Szawan, Konrad A., additional, Gili, Sebastiano, additional, D'Ascenzo, Fabrizio, additional, Dichtl, Wolfgang, additional, Citro, Rodolfo, additional, Bossone, Eduardo, additional, Neuhaus, Michael, additional, Franke, Jennifer, additional, Sorici‐Barb, Ioana, additional, Jaguszewski, Milosz, additional, Noutsias, Michel, additional, Knorr, Maike, additional, Heiner, Susanne, additional, Burgdorf, Christof, additional, Kherad, Behrouz, additional, Tschöpe, Carsten, additional, Sarcon, Annahita, additional, Shinbane, Jerold, additional, Rajan, Lawrence, additional, Michels, Guido, additional, Pfister, Roman, additional, Cuneo, Alessandro, additional, Jacobshagen, Claudius, additional, Karakas, Mahir, additional, Koenig, Wolfgang, additional, Pott, Alexander, additional, Meyer, Philippe, additional, Arroja, Jose David, additional, Banning, Adrian, additional, Cuculi, Florim, additional, Kobza, Richard, additional, Fischer, Thomas A., additional, Vasankari, Tuija, additional, Airaksinen, K.E. Juhani, additional, Napp, L. Christian, additional, Budnik, Monika, additional, Dworakowski, Rafal, additional, MacCarthy, Philip, additional, Kaiser, Christoph, additional, Osswald, Stefan, additional, Galiuto, Leonarda, additional, Chan, Christina, additional, Bridgman, Paul, additional, Beug, Daniel, additional, Delmas, Clément, additional, Lairez, Olivier, additional, El‐Battrawy, Ibrahim, additional, Akin, Ibrahim, additional, Gilyarova, Ekaterina, additional, Shilova, Alexandra, additional, Gilyarov, Mikhail, additional, Kozel, Martin, additional, Tousek, Petr, additional, Winchester, David E., additional, Galuszka, Jan, additional, Ukena, Christian, additional, Poglajen, Gregor, additional, Carrilho‐Ferreira, Pedro, additional, Hauck, Christian, additional, Paolini, Carla, additional, Bilato, Claudio, additional, Prasad, Abhiram, additional, Rihal, Charanjit S., additional, Liu, Kan, additional, Schulze, P. Christian, additional, Bianco, Matteo, additional, Jörg, Lucas, additional, Rickli, Hans, additional, Nguyen, Thanh H., additional, Kobayashi, Yoshio, additional, Böhm, Michael, additional, Maier, Lars S., additional, Pinto, Fausto J., additional, Widimský, Petr, additional, Borggrefe, Martin, additional, Felix, Stephan B., additional, Opolski, Grzegorz, additional, Braun‐Dullaeus, Ruediger C., additional, Rottbauer, Wolfgang, additional, Hasenfuß, Gerd, additional, Pieske, Burkert M., additional, Schunkert, Heribert, additional, Thiele, Holger, additional, Bauersachs, Johann, additional, Katus, Hugo A., additional, Horowitz, John, additional, Di Mario, Carlo, additional, Münzel, Thomas, additional, Crea, Filippo, additional, Bax, Jeroen J., additional, Lüscher, Thomas F., additional, Ruschitzka, Frank, additional, Ghadri, Jelena R., additional, and Templin, Christian, additional

Published
2019
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7. Interaction of systolic blood pressure and resting heart rate with clinical outcomes in takotsubo syndrome: insights from the International Takotsubo Registry.

Author

Böhm, Michael, Cammann, Victoria L., Ghadri, Jelena R., Ukena, Christian, Gili, Sebastiano, Di Vece, Davide, Kato, Ken, Ding, Katharina J., Szawan, Konrad A., Micek, Jozef, Jurisic, Stjepan, D'Ascenzo, Fabrizio, Frangieh, Antonio H., Rechsteiner, Delia, Seifert, Burkhardt, Ruschitzka, Frank, Lüscher, Thomas, Templin, Christian, on behalf of the InterTAK Collaborators, and D'Ascenzo, Fabrizio

Subjects
SYSTOLIC blood pressure, HEART beat, TAKOTSUBO cardiomyopathy, HEART failure, CARDIOVASCULAR diseases, BLOOD pressure, COMPARATIVE studies, CAUSES of death, CARDIAC contraction, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PROGNOSIS, RELAXATION for health, RESEARCH, SURVIVAL, EVALUATION research, DISEASE incidence, ACQUISITION of data, RETROSPECTIVE studies
Abstract

Aims: The present study aimed to determine the prognostic impact of resting heart rate (HR) and systolic blood pressure (SBP) in takotsubo syndrome (TTS).Methods and Results: Patients from the International Takotsubo Registry with complete data on HR and SBP were enrolled. We analysed all-cause mortality and major adverse cardiac and cerebrovascular events (MACCE) in tertiles of HR (<77 b.p.m., 77-94 b.p.m., >94 b.p.m.) and SBP (<119 mmHg, 119-140 mmHg, >140 mmHg). In addition, linear splines with interactions between HR and SBP were analysed. The risk of all-cause mortality was higher in the second HR tertile (1.89, 1.15-3.10; P = 0.012) and the third HR tertile (3.01, 1.90-4.79; P < 0.001) than in the first tertile. Similar effects were observed for MACCE. Low SBP was related to an increased risk of all-cause mortality (P < 0.001) and MACCE (P = 0.002). In a multivariable analysis of all-cause mortality, at HR >70 b.p.m., every 1 b.p.m. increase in HR was associated with a 1.7% increase (P < 0.001), and every 1 mmHg increase in SBP up to 130 mmHg was associated with a 2% risk reduction (P < 0.001). The risk of all-cause mortality thus was particularly elevated when low SBP occurred together with high HR.Conclusions: High HR and low SBP are associated with an increased risk of all-cause mortality in TTS. HR reduction might be worthy of being investigated as a therapeutic strategy for this condition and high HR and low SBP can be used to evaluate risk in this acute presentation of TTS.Clinical Trial Registration: ClinicalTrials.gov NCT01947621. [ABSTRACT FROM AUTHOR]

Published
2018
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8. A novel clinical score (InterTAK Diagnostic Score) to differentiate takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry.

Author

Ghadri, Jelena R., Cammann, Victoria L., Jurisic, Stjepan, Seifert, Burkhardt, Napp, L. Christian, Diekmann, Johanna, Bataiosu, Dana Roxana, D'Ascenzo, Fabrizio, Ding, Katharina J., Sarcon, Annahita, Kazemian, Elycia, Birri, Tanja, Ruschitzka, Frank, Lüscher, Thomas F., Templin, Christian, Jaguszewski, Milosz, Franke, Jennifer, Katus, Hugo A., Burgdorf, Christof, and Schunkert, Heribert

Subjects
TAKOTSUBO cardiomyopathy, ACUTE coronary syndrome, CONFIDENCE intervals, DISEASE prevalence, CORONARY disease, DIAGNOSIS, COMPARATIVE studies, DIFFERENTIAL diagnosis, ELECTROCARDIOGRAPHY, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PEPTIDE hormones, PEPTIDES, PROBABILITY theory, RESEARCH, EVALUATION research, RANDOMIZED controlled trials, ACQUISITION of data, RECEIVER operating characteristic curves, TROPONIN
Abstract

Aims: Clinical presentation of takotsubo syndrome (TTS) mimics acute coronary syndrome (ACS) and does not allow differentiation. We aimed to develop a clinical score to estimate the probability of TTS and to distinguish TTS from ACS in the acute stage.Methods and Results: Patients with TTS were recruited from the International Takotsubo Registry ( www.takotsubo-registry.com) and ACS patients from the leading hospital in Zurich. A multiple logistic regression for the presence of TTS was performed in a derivation cohort (TTS, n = 218; ACS, n = 436). The best model was selected and formed a score (InterTAK Diagnostic Score) with seven variables, and each was assigned a score value: female sex 25, emotional trigger 24, physical trigger 13, absence of ST-segment depression (except in lead aVR) 12, psychiatric disorders 11, neurologic disorders 9, and QTc prolongation 6 points. The area under the curve (AUC) for the resulting score was 0.971 [95% confidence interval (CI) 0.96-0.98] and using a cut-off value of 40 score points, sensitivity was 89% and specificity 91%. When patients with a score of ≥50 were diagnosed as TTS, nearly 95% of TTS patients were correctly diagnosed. When patients with a score ≤31 were diagnosed as ACS, ∼95% of ACS patients were diagnosed correctly. The score was subsequently validated in an independent validation cohort (TTS, n = 173; ACS, n = 226), resulting in a score AUC of 0.901 (95% CI 0.87-0.93).Conclusion: The InterTAK Diagnostic Score estimates the probability of the presence of TTS and is able to distinguish TTS from ACS with a high sensitivity and specificity.Trial Registration: NCT0194762. [ABSTRACT FROM AUTHOR]

Published
2017
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9. Impact of aspirin on takotsubo syndrome: a propensity score-based analysis of the InterTAK Registry.

Author

D'Ascenzo F, Gili S, Bertaina M, Iannaccone M, Cammann VL, Di Vece D, Kato K, Saglietto A, Szawan KA, Frangieh AH, Boffini B, Annaratone M, Sarcon A, Levinson RA, Franke J, Napp LC, Jaguszewski M, Noutsias M, Münzel T, Knorr M, Heiner S, Katus HA, Burgdorf C, Schunkert H, Thiele H, Bauersachs J, Tschöpe C, Pieske BM, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Hasenfuß G, Karakas M, Koenig W, Rottbauer W, Said SM, Braun-Dullaeus RC, Banning A, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Opolski G, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Crea F, Dichtl W, Franz WM, Empen K, Felix SB, Delmas C, Lairez O, El-Battrawy I, Akin I, Borggrefe M, Horowitz JD, Kozel M, Tousek P, Widimský P, Gilyarova E, Shilova A, Gilyarov M, Biondi-Zoccai G, Winchester DE, Ukena C, Neuhaus M, Bax JJ, Prasad A, Di Mario C, Böhm M, Gasparini M, Ruschitzka F, Bossone E, Citro R, Rinaldi M, De Ferrari GM, Lüscher T, Ghadri JR, and Templin C

Subjects
Heart Failure, Humans, Ischemic Attack, Transient, Myocardial Infarction, Platelet Aggregation Inhibitors therapeutic use, Propensity Score, Recurrence, Registries, Stroke, Treatment Outcome, Aspirin therapeutic use, Takotsubo Cardiomyopathy drug therapy, Takotsubo Cardiomyopathy epidemiology
Abstract

Aims: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS)., Methods and Results: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50-3.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78-1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting., Conclusion: In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621., (© 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology.)

Published
2020
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