1. MYO9B polymorphisms in multiple sclerosis
- Author
-
Annette Bang Oturai, Hanne F. Harbo, Lars P. Ryder, Aarno Palotie, Elisabeth Gulowsen Celius, Mark J. Daly, Frida Lundmark, Pentti J. Tienari, Keijo Koivisto, Ilkka Rautakorpi, Minna Suvela, Mauri Reunanen, Leena Peltonen, Anu Kemppinen, Tuula Pirttilä, Janna Saarela, Jan Hillert, Irina Elovaara, Institute for Molecular Medicine Finland, Research Programs Unit, Research Programme for Molecular Neurology, Neurologian yksikkö, Finnish Genome Center (-2009), Genomics of Neurological and Neuropsychiatric Disorders, and Department of Medical and Clinical Genetics
- Subjects
Multiple Sclerosis ,Genotype ,Short Report ,Single-nucleotide polymorphism ,312 Clinical medicine ,Myosins ,Biology ,medicine.disease_cause ,White People ,Autoimmunity ,03 medical and health sciences ,0302 clinical medicine ,Polymorphism (computer science) ,Genetic variation ,Genetics ,medicine ,Humans ,311 Basic medicine ,Family ,Gene ,Genetics (clinical) ,030304 developmental biology ,0303 health sciences ,Polymorphism, Genetic ,318 Medical biotechnology ,Multiple sclerosis ,Case-control study ,217 Medical engineering ,medicine.disease ,3. Good health ,Case-Control Studies ,Immunology ,030211 gastroenterology & hepatology ,118 Biological sciences - Abstract
"Single-nucleotide polymorphisms (SNPs) in the 30 region of myosin IXB (MYO9B) gene have recently been reported to associate with different inflammatory or autoimmune diseases. We monitored for the association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations. First, 18 SNPs including 6 SNPs with previous evidence for association to immune disorders, were tested in 730 Finnish MS families, but no linkage or family-based association was observed. To ensure the power to detect variants with a modest effect size, we further analyzed 10 variants in 899 Finnish cases and 1325 controls, and in a total of 1521 cases and 1476 controls from Denmark, Norway and Sweden, but found no association. Our results thereby do not support a major function of the tested MYO9B variants in MS. European Journal of Human Genetics (2009) 17, 840-843; doi: 10.1038/ejhg.2008.251; published online 14 January 2009" "Single-nucleotide polymorphisms (SNPs) in the 30 region of myosin IXB (MYO9B) gene have recently been reported to associate with different inflammatory or autoimmune diseases. We monitored for the association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations. First, 18 SNPs including 6 SNPs with previous evidence for association to immune disorders, were tested in 730 Finnish MS families, but no linkage or family-based association was observed. To ensure the power to detect variants with a modest effect size, we further analyzed 10 variants in 899 Finnish cases and 1325 controls, and in a total of 1521 cases and 1476 controls from Denmark, Norway and Sweden, but found no association. Our results thereby do not support a major function of the tested MYO9B variants in MS. European Journal of Human Genetics (2009) 17, 840-843; doi: 10.1038/ejhg.2008.251; published online 14 January 2009" "Single-nucleotide polymorphisms (SNPs) in the 30 region of myosin IXB (MYO9B) gene have recently been reported to associate with different inflammatory or autoimmune diseases. We monitored for the association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations. First, 18 SNPs including 6 SNPs with previous evidence for association to immune disorders, were tested in 730 Finnish MS families, but no linkage or family-based association was observed. To ensure the power to detect variants with a modest effect size, we further analyzed 10 variants in 899 Finnish cases and 1325 controls, and in a total of 1521 cases and 1476 controls from Denmark, Norway and Sweden, but found no association. Our results thereby do not support a major function of the tested MYO9B variants in MS. European Journal of Human Genetics (2009) 17, 840-843; doi: 10.1038/ejhg.2008.251; published online 14 January 2009"
- Published
- 2009
- Full Text
- View/download PDF