1. Genetic variants in RBFOX3 are associated with sleep latency
- Author
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Amin, N. (Najaf), Allebrandt, K.V., Spek, A. (Ashley) van der, Müller-Myhsok, B. (B.), Hek, K. (Karin), Teder-Laving, M. (Maris), Hayward, C. (Caroline), Esko, T. (Tõnu), Mill, J. van, Mbarek, H., Watson, N.F. (Nathaniel F), Melville, S.A. (Scott), Del Greco, F.M. (Fabiola), Byrne, E.M. (Enda), Oole, E. (Edwin), Kolcic, I. (Ivana), Chen, T.H., Evans, D.S. (Daniel), Coresh, J. (Josef), Vogelzangs, N. (Nicole), Karjalainen, J. (Juha), Willemsen, G.A.H.M. (Gonneke), Gharib, S.A. (Sina), Zgaga, L. (Lina), Mihailov, E. (Evelin), Stone, K.L. (Katie L), Campbell, H. (Harry), Brouwer, R.W.W. (Rutger), Demirkan, A. (Ayşe), Isaacs, A.J. (Aaron), Dogas, Z., Marciante, K. (Kristin), Campbell, S. (Susan), Borovecki, F. (Fran), Luik, A.I. (Annemarie), Li, M. (Man), Hottenga, J.J. (Jouke Jan), Huffman, J.E. (Jennifer), van den hout, M.C.G.N. (Mirjam), Cummings, S.R. (Steven R.), Aulchenko, Y.S. (Yurii), Gehrman, P.R. (Philip), Uitterlinden, A.G. (André), Wichmann, H.E. (Heinz Erich), Müller-Nurasyid, M. (Martina), Fehrmann, R.S.N. (Rudolf), Montgomery, G.W. (Grant), Hofman, A. (Albert), Kao, W.H.L. (Wen Hong Linda), Oostra, B.A. (Ben), Wright, A. (Alan), Vink, J.M. (Jacqueline), Wilson, J.F. (James F), Pramstaller, P.P. (Peter Paul), Hicks, A.A. (Andrew), Polasek, O. (Ozren), Punjabi, N.M. (Naresh), Redline, S. (Susan), Psaty, B.M. (Bruce), Heath, A.C. (Andrew C.), Merrow, M., Tranah, G.J. (Gregory), Gottlieb, D.J. (Daniel J), Boomsma, D.I. (Dorret), Martin, N.G. (Nicholas), Rudan, I. (Igor), Tiemeier, H.W. (Henning), IJcken, W.F.J. (Wilfred) van, Penninx, B.W.J.H., Metspalu, A. (Andres), Meitinger, T. (Thomas), Franke, L. (Lude), Roenneberg, T., Duijn, C.M. (Cornelia) van, Amin, N. (Najaf), Allebrandt, K.V., Spek, A. (Ashley) van der, Müller-Myhsok, B. (B.), Hek, K. (Karin), Teder-Laving, M. (Maris), Hayward, C. (Caroline), Esko, T. (Tõnu), Mill, J. van, Mbarek, H., Watson, N.F. (Nathaniel F), Melville, S.A. (Scott), Del Greco, F.M. (Fabiola), Byrne, E.M. (Enda), Oole, E. (Edwin), Kolcic, I. (Ivana), Chen, T.H., Evans, D.S. (Daniel), Coresh, J. (Josef), Vogelzangs, N. (Nicole), Karjalainen, J. (Juha), Willemsen, G.A.H.M. (Gonneke), Gharib, S.A. (Sina), Zgaga, L. (Lina), Mihailov, E. (Evelin), Stone, K.L. (Katie L), Campbell, H. (Harry), Brouwer, R.W.W. (Rutger), Demirkan, A. (Ayşe), Isaacs, A.J. (Aaron), Dogas, Z., Marciante, K. (Kristin), Campbell, S. (Susan), Borovecki, F. (Fran), Luik, A.I. (Annemarie), Li, M. (Man), Hottenga, J.J. (Jouke Jan), Huffman, J.E. (Jennifer), van den hout, M.C.G.N. (Mirjam), Cummings, S.R. (Steven R.), Aulchenko, Y.S. (Yurii), Gehrman, P.R. (Philip), Uitterlinden, A.G. (André), Wichmann, H.E. (Heinz Erich), Müller-Nurasyid, M. (Martina), Fehrmann, R.S.N. (Rudolf), Montgomery, G.W. (Grant), Hofman, A. (Albert), Kao, W.H.L. (Wen Hong Linda), Oostra, B.A. (Ben), Wright, A. (Alan), Vink, J.M. (Jacqueline), Wilson, J.F. (James F), Pramstaller, P.P. (Peter Paul), Hicks, A.A. (Andrew), Polasek, O. (Ozren), Punjabi, N.M. (Naresh), Redline, S. (Susan), Psaty, B.M. (Bruce), Heath, A.C. (Andrew C.), Merrow, M., Tranah, G.J. (Gregory), Gottlieb, D.J. (Daniel J), Boomsma, D.I. (Dorret), Martin, N.G. (Nicholas), Rudan, I. (Igor), Tiemeier, H.W. (Henning), IJcken, W.F.J. (Wilfred) van, Penninx, B.W.J.H., Metspalu, A. (Andres), Meitinger, T. (Thomas), Franke, L. (Lude), Roenneberg, T., and Duijn, C.M. (Cornelia) van
- Abstract
Time to fall asleep (sleep latency) is a major determinant of sleep quality. Chronic, long sleep latency is a major characteristic of sleep-onset insomnia and/or delayed sleep phase syndrome. In this study we aimed to discover common polymorphisms that contribute to the genetics of sleep latency. We performed a meta-analysis of genome-wide association studies (GWAS) including 2 572 737 single nucleotide polymorphisms (SNPs) established in seven European cohorts including 4242 individuals. We found a cluster of three highly correlated variants (rs9900428, rs9907432 and rs7211029) in the RNA-binding protein fox-1 homolog 3 gene (RBFOX3) associated with sleep latency (P-values=5.77 × 10-08, 6.59 × 10- 08 and 9.17 × 10- 08). These SNPs were replicated in up to 12 independent populations including 30 377 individuals (P-values=1.5 × 10- 02, 7.0 × 10- 03 and 2.5 × 10- 03; combined meta-analysis P-values=5.5 × 10-07, 5.4 × 10-07 and 1.0 × 10-07). A functional prediction of RBFOX3 based
- Published
- 2016
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