1. Alterations in KLRB1 gene expression and a Scandinavian multiple sclerosis association study of the KLRB1 SNP rs4763655
- Author
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Jeppe Romme Christensen, Magdalena Lindén, Finn Sellebjerg, Tomas Olsson, Annette Bang Oturai, Ingrid Kockum, Kjell-Morten Myhr, Elisabeth Gulowsen Celius, Inger-Lise Mero, Hanne F. Harbo, Per Soelberg Sørensen, Lars Börnsen, Helle Bach Søndergaard, and Jan Hillert
- Subjects
Male ,Multiple Sclerosis ,Short Report ,Genome-wide association study ,Scandinavian and Nordic Countries ,Biology ,KLRB1 Gene ,Polymorphism, Single Nucleotide ,Pathogenesis ,Gene Frequency ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Genetics (clinical) ,Autoimmune disease ,Regulation of gene expression ,Multiple sclerosis ,Case-control study ,medicine.disease ,KLRB1 ,Gene Expression Regulation ,Case-Control Studies ,Immunology ,Female ,Genome-Wide Association Study ,NK Cell Lectin-Like Receptor Subfamily B - Abstract
Multiple sclerosis (MS) is a complex autoimmune disease affecting genetically susceptible individuals. A genome-wide association study performed by the International MS Genetics Consortium identified several putative susceptibility genes; among these, the KLRB1 gene is represented by the single-nucleotide polymorphism rs4763655. We could confirm a marginally significant association between rs4763655 and MS (P=0.046, odds ratio=1.06 (1.00–1.13)) in a large Scandinavian case–control study of 5367 MS patients and 4485 controls. The expression of KLRB1 in blood from MS patients was higher compared with healthy controls (P
- Published
- 2011
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