1. Association between survivin −31G>C promoter polymorphism and cancer risk: a meta-analysis.
- Author
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Wang, Xiefeng, Huang, Lili, Xu, Yanjie, Shi, Zhumei, Wang, Yingyi, Zhang, Junxia, Wang, Xirui, Cao, Lei, Luo, Hui, Chen, Jiawei, Liu, Ning, Yin, Yongmei, and You, Yongping
- Subjects
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SURVIVIN (Protein) , *GENETIC polymorphisms , *CANCER risk factors , *META-analysis , *DISEASE susceptibility - Abstract
Survivin is an inhibitor of apoptosis protein and has a crucial role in the development of cancer. The survivin −31G>C (rs9904341) promoter polymorphism influences survivin expression and has been implicated in cancer risk. However, conflicting results have been published from studies on the association between survivin −31G>C polymorphism and the risk of cancer. To clarify the role of this polymorphism in cancer, we performed a meta-analysis of all available and relevant published studies, involving a total of 3485 cancer patients and 3964 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. The overall results indicated that the variant genotypes were associated with a significantly increased cancer risk (CC vs GG: OR=1.58, 95% CI=1.20-2.10; CC/GC vs GG: OR=1.23, 95% CI=1.00-1.51; CC vs GG/GC: OR=1.51, 95% CI=1.23-1.85). In the stratified analyses, significantly increased risk was associated with the Asian populations (CC vs GG: OR=1.67, 95% CI=1.16-2.40; CC vs GG/GC: OR=1.50, 95% CI=1.17-1.91). We also performed the analyses by cancer type, and no statistical association was observed. The results suggest that the survivin −31G>C promoter polymorphism might be associated with an increased risk of cancer, especially in the Asian populations. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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