1. Combined modality PET/MR for the detection of severe large vessel vasculitis
- Author
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John W. Cerne, Sophia Liu, Muhammad Umair, Ashitha Pathrose, Jackson E. Moore, Bradley D. Allen, Michael Markl, James C. Carr, Hatice Savas, Lisa Wilsbacher, and Ryan Avery
- Subjects
PET ,MRI ,Inflammation ,Vasculitis ,Giant cell arteritis ,Takayasu arteritis ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background Large vessel vasculitis (LVV) can be characterized based on symptom severity, and this characterization helps clinicians decide upon treatment approach. Our aim was to compare the imaging findings of combined modality positron emission tomography/magnetic resonance (PET/MR) and inflammatory markers between severe and non-severe LVV. A retrospective query was performed to identify all patients with LVV who underwent PET/MR at our institution between January 2015 and January 2021. Results Eleven patients (nine females; age 62.2 ± 16.4 years) underwent 15 PET/MR scans. Positivity was defined by findings indicative of active LVV on each modality: PET positive if vessel metabolic activity > liver metabolic activity; MR positive if wall thickening or contrast enhancement. When positive PET or positive MR findings were considered a positive scan, LVV patients with severe disease (n = 9 scans) showed a higher number of positive scans (n = 9) compared to the number of positive scans in non-severe patients (n = 3) (p
- Published
- 2022
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