1. Requirement of H-2 heterozygosity for autoimmunity in (NZB × NZW)F1 hybrid mice
- Author
-
Short Paper, Sachiko Hirose, Genjiro Ueda, Kazuo Noguchi, Takashi Okada, Iwao Sekigawa, Hidetoshi Sato, and Toshikazu Shirai
- Subjects
Heterozygote ,Receptors, Antigen, T-Cell, alpha-beta ,Immunology ,Receptors, Antigen, T-Cell ,Congenic ,chemical and pharmacologic phenomena ,urologic and male genital diseases ,medicine.disease_cause ,Immunoglobulin G ,Autoimmune Diseases ,Autoimmunity ,Pathogenesis ,Loss of heterozygosity ,Mice ,Immune system ,immune system diseases ,medicine ,Animals ,Immunology and Allergy ,skin and connective tissue diseases ,Autoimmune disease ,Mice, Inbred NZB ,biology ,H-2 Antigens ,DNA ,medicine.disease ,Peptide Fragments ,biology.protein ,Hybridization, Genetic ,Antibody - Abstract
In the F1 hybrid of autoimmune New Zealand Black (NZB) and phenotypically normal New Zealand White (NZW) mice, there occurs a severe systemic lupus erythematosus (SLE)-like autoimmune disease more fulminant than that found in the parental NZB mice. To determine the role of the H-2 complex in the pathogenesis of autoimmune disease of the (NZB X NZW)F1 hybrid, we developed H-2-congenic NZB (NZB.H-2z) and NZW (NZW.H-2d) strains, and compared the degree of autoimmune features between congenic H-2d/H-2d and H-2z/H-2z homozygous F1 hybrids and the original H-2d/H-2z heterozygous (NZB X NZW)F1 hybrid. We found that autoimmune features such as productions of IgG class anti-DNA antibodies and retroviral gp70 immune complexes and the development of renal disease were to a great extent reduced in both H-2 homozygous F1 hybrids, as compared with the H-2 heterozygous (NZB X NZW)F1 hybrid. It would thus appear that the heterozygosity of H-2d haplotype derived from NZB and H-2z from NZW is essential for the autoimmune disease characteristic of the (NZB X NZW)F1 hybrid.
- Published
- 1986