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Start Over Descriptor "Tbet" Journal european journal of immunology
2 results on '"Tbet"'

1. Murine thymic NK cells: A case of identity.

Author

Male, Victoria and Brady, Hugh J. M.

Abstract

Just over a decade ago, it was established that NK cells in the thymus do not follow precisely the same developmental pathway as conventional NK cells that develop in the bone marrow. Subsequently, it has emerged that NK cells are one branch of a family of innate lymphoid cells (ILCs). ILC1s and thymic NK cells have, however, sufficient similarities such that questions have been raised about how distinctive each cell type is from the other. In this issue of European Journal of Immunology, Gabrielli et al. [Eur. J. Immunol. 2017. 47: 800-805] make a detailed study of the transcription factor requirements of murine thymic NK cells. They provide a valuable insight into the distinctive identity of thymic NK cells with regard to Tbet, Nfil3, Id2, and Ets1. In addition, they clarify the nature of DX5 expression on NK cells and ILC-like cells in the murine thymus. [ABSTRACT FROM AUTHOR]

Published
2017
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2. Murine thymic NK cells: A case of identity

Author

Hugh J.M. Brady and Victoria Male

Subjects
0301 basic medicine, Cell type, Ets1, Cellular differentiation, Nfil3, Immunology, PROGRAMMED DEATH-1, Id2, Biology, Natural Killer cell, DENDRITIC CELLS, Article, ILC1, GASTRIC EPITHELIAL-CELLS, Natural killer cell, Mice, 03 medical and health sciences, CHRONIC VIRAL-INFECTION, PD-1 UP-REGULATION, medicine, Animals, Humans, Immunology and Allergy, Cell Lineage, REGULATORY T-CELLS, MEDIATED ANTITUMOR IMMUNITY, Science & Technology, Lymphokine-activated killer cell, LIGAND 1 PD-L1, Innate lymphoid cell, NFIL3, Cell Differentiation, Natural killer T cell, Thymus, Killer Cells, Natural, 030104 developmental biology, medicine.anatomical_structure, 1107 Immunology, TUMOR-INFILTRATING CD8(+), Bone marrow, Transcription factor, Life Sciences & Biomedicine, CHRONIC HEPATITIS-B, Tbet, Transcription Factors
Abstract

Group 1 innate lymphoid cells include natural killer (NK) cells and ILC1s, which mediate the response to intracellular pathogens. Thymic NK (tNK) cells were described with hybrid features of immature NK cells and ILC1 but whether these cells are related to NK cells or ILC1 has not been fully investigated. We report that murine tNK cells expressed the NK-cell associated transcription factor EOMES and developed independent of the essential ILC1 factor TBET confirming their placement within the NK lineage. Moreover, tNK cells resemble NK cells rather than ILC1 in their requirements for the E protein transcription factor inhibitor ID2. We provide further insight into the mechanisms governing tNK-cell development by showing that the transcription factor ETS1 prevented tNK cell acquisition of the conventional NK cell maturation markers CD11b and KLRG1. Our data reveal few ILC1 in the thymus and clarify the identity and developmental requirements of tNK cells.

Published
2017
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