1. trans-Dinitrosyl-Substituted Hexamolybdate and Study of Its Controllable NO Release.
- Author
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Zhang, Jiangwei, Hao, Jian, Khan, Rao Naumaan Nasim, Zhang, Jin, and Wei, Yongge
- Subjects
DICYCLOHEXYLCARBODIIMIDE ,POLYOXOMETALATES ,INFRARED spectroscopy ,X-ray diffraction ,ULTRAVIOLET spectroscopy - Abstract
On the basis of the well-developed N, N′-dicyclohexylcarbodiimide (DCC) imidoylization strategy, the novel trans-dinitrosyl-substituted polyoxometalate (POM) (NBu
4 )4 [Mo6 O17 (≡NO)2 ] was synthesized in moderate yield with high purity through a highly selective reaction route under mild reaction conditions. Its structure was elucidated by IR and UV/Vis spectroscopy, ESI-MS, and single-crystal X-ray diffraction studies. Furthermore, its ability to undergo controlled NO release was confirmed by ESI-MS, and a curve of the amount of NO released as a function of time within a simulated body fluid system was obtained by UV spectroscopy. The rate of NO release is controlled by changing the pH of the system. This is the first time that the decomposition of a POM has been used to produce therapeutic NO species. This study provides a new route to controlled-release technology for NO storage and targeted delivery. [ABSTRACT FROM AUTHOR]- Published
- 2013
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