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This review consolidates the evidence supporting endogenous HNO generation through enzymatic and non‐enzymatic pathways, emphasizing advancements in real‐time HNO sensing within living systems. Azanone (nitroxyl, HNO) is the one‐electron‐reduced congener of nitric oxide (NO•) and shares various biological actions. HNO exhibits unique properties, including positive inotropic and lusitropic effects, along with resistance to scavenging by reactive oxygen species (ROS), particularly superoxide. Research on HNO has intensified over the last two decades, focusing on its reactivity and the prospect of endogenous formation due to its potential significance. The high reactivity of HNO arises from reactions with biologically relevant species such as oxygen, NO•, and thiols, as well as self‐dimerization. Detecting and quantifying HNO has posed challenges, initially relying on nitrous oxide (N2O) detection, a byproduct of dimerization. Recent advancements, including fluorescent probes and a specific electrochemical nanomolar‐level sensor, have facilitated direct detection, enhancing understanding of HNO reactivity and formation. [ABSTRACT FROM AUTHOR]

The article titled "Update on Endogenous HNO Production: An Exploration of Unanswered Questions and Challenges" in the European Journal of Inorganic Chemistry discusses the biological function of HNO and its generation in living organisms. The article presents various mechanistic proposals for the production of HNO, categorized as enzymatic or non-enzymatic. The importance of HNO in medicine, particularly in cardiovascular health, is highlighted, emphasizing its potential. Additionally, the article mentions that HNO levels in plant leaf cells can vary in response to developmental processes and environmental factors. The full details can be found in the review by P. Vargas, F. A. Doctorovich, and S. A. Suarez. [Extracted from the article]

Keywords: Electrochemistry; Macromolecules; Metal-organic frameworks; Metalloporphyrins; Sensors; Transition metals EN Electrochemistry Macromolecules Metal-organic frameworks Metalloporphyrins Sensors Transition metals 1 1 1 06/15/23 20230613 NES 230613 B The Front Cover b shows an engaging platform for electrochemical sensor development: Metalloporphyrins. Front Cover: Versatile Metalloporphyrin-Based Electrochemical Sensing Applications: From Small Gasotransmitters to Macromolecules (Eur. J. Inorg. Electrochemistry, Macromolecules, Metal-organic frameworks, Metalloporphyrins, Sensors, Transition metals. [Extracted from the article]