1. Estimated 10-year cardiovascular risk in a large Italian cohort of rheumatoid arthritis patients: Data from the Cardiovascular Obesity and Rheumatic DISease (CORDIS) Study Group.
- Author
-
Cacciapaglia, Fabio, Spinelli, Francesca Romana, Piga, Matteo, Erre, Gian Luca, Sakellariou, Garifallia, Manfredi, Andreina, Viapiana, Ombretta, Fornaro, Marco, Colella, Sergio, Floris, Alberto, Mangoni, Arduino Aleksander, Castagna, Floriana, Vacchi, Caterina, Orsolini, Giovanni, Bugatti, Serena, Cafaro, Giacomo, Cauli, Alberto, Gremese, Elisa, Atzeni, Fabiola, and Bartoloni, Elena more...
- Subjects
- *
RHEUMATISM , *RHEUMATOID arthritis , *CARDIOVASCULAR diseases risk factors , *DISEASE remission , *GLYCEMIC control - Abstract
• The 10-year cardiovascular (CV) risk is 3- to 4-fold higher in rheumatoid arthritis (RA) patients compared to age- and sex-matched osteoarthritis patients. • A careful surveillance for CV disease is mandatory for all physicians that manage RA patients applying the "Systematic COronary Risk Evaluation" (SCORE) and the "Progetto Cuore" charts for Italian patients. • Refrain from smoking, improve blood pressure and glycaemic levels control and sustained remission or low disease activity, represent the most pertinent CV prevention measures in RA patients. Several cardiovascular (CV) risk algorithms are available to predict CV events in the general population. However, their performance in patients with rheumatoid arthritis (RA) might differ from the general population. This cross-sectional multicentre study aimed to estimate the 10-year CV risk using two different algorithms in a large RA cohort and in patients with osteoarthritis (OA). In a consecutive series of RA patients and matched OA controls without prior CV events, clinical and serologic data and traditional CV risk factors were recorded. The 10-year CV risk was assessed with the Systematic COronary Risk Evaluation (SCORE) and the "Progetto Cuore" algorithms. 1,467 RA patients and 342 OA subjects were included. RA patients were more frequently diabetic (9.9% vs 6.4%; p=0.04) and smokers (20.4% vs 12.5%; p=0.002) but had lower prevalence of obesity (15% vs 21%; p=0.003). Dyslipidaemia was more prevalent in OA (32.5% vs 21.7%; p<0.0001). The 10-year estimated CV risk was 1.6% (95%CI 1.3-1.9) in RA and 1.4% (95%CI 1.3-1.6) in OA (p=0.002) according to SCORE and 6.5% (95%CI 6.1-6.9) in RA and 4.4% (95%CI 3.9-5.1) in OA (p<0.001) according to "Progetto Cuore". Regardless of the score used, RA patients had a 3- to-4-fold increased 10-year risk of CV events compared to OA subjects. RA patients have a significantly higher 10-year risk of CV events than OA subjects. In addition to effective disease control and joint damage prevention, specific protective measures targeting modifiable traditional CV risk factors should be implemented in RA. [ABSTRACT FROM AUTHOR] more...
- Published
- 2022
- Full Text
- View/download PDF