1. Increased expression of markers of early atherosclerosis in patients with inflammatory bowel disease
- Author
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Antonio Craxì, Antonino Tuttolomondo, Vincenza Calvaruso, Giuseppe Licata, Daniele Torres, Maria Perticone, Vittoriano Della Corte, Maria Cappello, Alessandra F. Aiello, Anna Licata, Ivana Bravatà, Calogero Cammà, Cappello, M., Licata, A., Calvaruso, V., Bravatà, I., Aiello, A., Torres, D., Della Corte, V., Tuttolomondo, A., Perticone, M., Licata, G., Craxì, A., and Cammà, C.
- Subjects
Adult ,Male ,medicine.medical_specialty ,IBD ,030204 cardiovascular system & hematology ,Pulse Wave Analysis ,Inflammatory bowel disease ,Carotid Intima-Media Thickness ,Carotid intima-media thickne ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Vascular Stiffness ,Crohn Disease ,Risk Factors ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Mesalamine ,Pulse wave velocity ,Triglycerides ,Subclinical infection ,Crohn's disease ,biology ,business.industry ,C-reactive protein ,Anti-Inflammatory Agents, Non-Steroidal ,Cholesterol, HDL ,Cholesterol, LDL ,medicine.disease ,Atherosclerosis ,Inflammatory Bowel Diseases ,Arterial stiffne ,Blood pressure ,Carotid Arteries ,Cholesterol ,Intima-media thickness ,Case-Control Studies ,Immunology ,Early atherosclerosi ,Arterial stiffness ,Cardiology ,biology.protein ,030211 gastroenterology & hepatology ,Colitis, Ulcerative ,Female ,business ,Biomarkers - Abstract
Recent studies documented an increased cardiovascular risk in patients with inflammatory bowel disease (IBD). Our study aimed at investigating the prevalence of intima-media thickness (IMT) of the carotid arteries and the arterial stiffness indices as markers of early atherosclerosis in young IBD patients.We recruited 68 consecutive IBD patients, and 38 matched healthy controls less than 45years old (median age 31.6±8.1years). Clinical and demographic features, cardiovascular risk factors, history of cardiovascular events, concomitant therapies were registered on a dedicate database. Carotid IMT was evaluated by using high resolution B-mode ultrasonography. Arterial stiffness was assessed by measurement of carotid-femoral Pulse Wave Velocity (PWV) and Augmentation Index (AIx).Total cholesterol (P0.013) and LDL-cholesterol (P0.019) levels were significantly lower in IBD patients compared to controls. Carotid IMT was higher in IBD than in controls (P0.047), but there was no statistically significant difference among Crohn's Disease (CD) and Ulcerative Colitis (UC) patients. Moreover, PWV and AIx were significantly higher in patients as compared to controls (P0.006 and P0.004 respectively). No medication seemed to affect vascular measurements, though stiffness parameters were significantly higher in patients treated with 5-ASA (11.9 (9.7) vs 18.2 (10.2), P0.021), suggesting a lack of efficacy of 5-ASA in protecting IBD patients from early atherogenesis.Young IBD patients show an increase in subclinical markers of atherosclerosis. Future studies need to address whether these markers result in an increased risk of cardiovascular events in these patient.
- Published
- 2016