1. Age-related changes in the lateral lipid distribution in a human lens described by mass spectrometry imaging
- Author
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Ondrej Vlacil, Helena Faltyskova, Jaroslav Pól, Michael Volný, Vladimír Havlíček, Marian Hajduch, Lukas Krasny, and Karel Lemr
- Subjects
Chemistry ,Analytical chemistry ,General Medicine ,Mass spectrometry ,Atomic and Molecular Physics, and Optics ,Mass spectrometry imaging ,law.invention ,Lens (optics) ,Mass ,law ,Potential biomarkers ,Age related ,Biophysics ,Distribution (pharmacology) ,Sphingomyelin ,Spectroscopy - Abstract
The lateral lipid distribution in eye lenses of three human donors were studied by matrix-assisted laser desorption ionization imaging mass spectrometry using a high mass resolution. By using exact mass measurements this study shows the relationship between the aging process and the number of lipids detected as well as between aging and the abundance of products derived from sphingomyelins by hydrolysis. Variable lipid composition was also observed in the nuclear, barrier, or cortex regions of the lens samples. This is the first study that suggests the distribution of lysolipids as a potential biomarker panel for the aging of human lens tissue.
- Published
- 2015