1. Cathepsin B: The dawn of tumor therapy.
- Author
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Liu, Fuxian, Zhou, Ting, Zhang, Shangzu, Li, Yangyang, Chen, Yan, Miao, Zhiming, Wang, Xin, Yang, Gengqiang, Li, Qiyang, Zhang, Liying, and Liu, Yongqi
- Subjects
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CATHEPSIN B , *CHINESE medicine , *TUMOR growth , *NATURAL products - Abstract
Cathepsin B (CTSB) is a key lysosomal protease that plays a crucial role in the development of cancer. This article elucidates the relationship between CTSB and cancer from the perspectives of its structure, function, and role in tumor growth, migration, invasion, metastasis, angiogenesis and autophagy. Further, we summarized the research progress of cancer treatment related drugs targeting CTSB, as well as the potential and advantages of Traditional Chinese medicine in treating tumors by regulating the expression of CTSB. [Display omitted] • CTSB promotes tumor cell invasion and metastasis, and angiogenesis, inflammation and autophagy promote tumor development. • Traditional Chinese medicine and natural products can target CTSB to play an anti-tumor role. • A variety of CTSB inhibitors are summarized, and their mechanisms of action, advantages and disadvantages are clearly outlined. • CTSB has reliable practical significance in nanomedicine diagnosis and treatment. • Targeting CTSB holds great promise in providing novel therapeutic approaches for cancer treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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