210 results on '"Liu, Hong"'
Search Results
2. Identification and biological evaluation of fused tetrahydroisoquinoline derivatives as Wnt/β-catenin signaling inhibitors to suppress colorectal cancer
3. Discovery of novel pyrazolo[1,5-a]pyrimidine derivatives as potent reversal agents against ABCB1-mediated multidrug resistance
4. A comprehensive review of new small molecule drugs approved by the FDA in 2022: Advance and prospect
5. Micafungin: A promising inhibitor of UBE2M in cancer cell growth suppression
6. Novel acridine-based LSD1 inhibitors enhance immune response in gastric cancer
7. The recent advance of Interleukin-1 receptor associated kinase 4 inhibitors for the treatment of inflammation and related diseases
8. Development of sertraline analogues as potential anti-ischemic stroke agents
9. Application and synthesis of thiazole ring in clinically approved drugs
10. Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2
11. Triazole-fused pyrimidines in target-based anticancer drug discovery
12. New drug approvals for 2021: Synthesis and clinical applications
13. 2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization
14. Oxazolidinone: A promising scaffold for the development of antibacterial drugs
15. Structure-based design, synthesis and biological evaluation of aminopyrazines as highly potent, selective, and cellularly active allosteric SHP2 inhibitors
16. Synthesis, biological evaluation and cellular localization study of fluorescent derivatives of Jiyuan Oridonin A
17. Biotinylated curcumin as a novel chemosensitizer enhances naphthalimide-induced autophagic cell death in breast cancer cells
18. Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors and PROTAC-based degraders for cancer therapy
19. Discovery of a cinnamyl piperidine derivative as new neddylation inhibitor for gastric cancer treatment
20. 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
21. Overview of all-trans-retinoic acid (ATRA) and its analogues: Structures, activities, and mechanisms in acute promyelocytic leukaemia
22. Identification of novel 1,3-diaryl-1,2,4-triazole-capped histone deacetylase 6 inhibitors with potential anti-gastric cancer activity
23. Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors
24. Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer
25. RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic
26. Discovery of [1,2,4]triazolo[1,5-a]pyrimidines derivatives as potential anticancer agents
27. Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
28. Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers
29. Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells
30. Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents
31. Targeting histone demethylase KDM5B for cancer treatment
32. The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020
33. New drug approvals for 2019: Synthesis and clinical applications
34. Medicinal chemistry strategies for the development of protein tyrosine phosphatase SHP2 inhibitors and PROTAC degraders
35. The design, synthesis and anti-tumor mechanism study of new androgen receptor degrader
36. Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway
37. Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway
38. Discovery of tofacitinib derivatives as orally active antitumor agents based on the scaffold hybridization strategy
39. Drug repurposing: Discovery of troxipide analogs as potent antitumor agents
40. Pyrimidine: A promising scaffold for optimization to develop the inhibitors of ABC transporters
41. Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents
42. Discovery of novel tertiary amide derivatives as NEDDylation pathway activators to inhibit the tumor progression in vitro and in vivo
43. Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B)
44. Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors
45. Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors
46. Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent
47. Novel tertiary sulfonamide derivatives containing benzimidazole moiety as potent anti-gastric cancer agents: Design, synthesis and SAR studies
48. Synthesis and in vitro biological evaluation of novel derivatives of Flexicaulin A condensation with amino acid trifluoroacetate
49. Synthesis and anti-gastric cancer activity evaluation of novel triazole nucleobase analogues containing steroidal/coumarin/quinoline moieties
50. Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
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