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Your search keyword '"Liu, Hong"' showing total 3 results
3 results on '"Liu, Hong"'

1. Design and synthesis of novel 1,2,3-triazole-pyrimidine hybrids as potential anticancer agents.

Author

Ma, Li-Ying, Pang, Lu-Ping, Wang, Bo, Zhang, Miao, Hu, Biao, Xue, Deng-Qi, Shao, Kun-Peng, Zhang, Bao-Le, Liu, Ying, Zhang, En, and Liu, Hong-Min

Subjects
*PYRIMIDINES, *DRUG design, *ANTINEOPLASTIC agent synthesis, *CANCER cells, *CELL lines, *APOPTOSIS
Abstract

A series of novel 1,2,3-triazole-pyrimidine hybrids were designed, synthesized and evaluated for their anticancer activity against four selected cancer cell lines (MGC-803, EC-109, MCF-7 and B16-F10). Most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected. Compound 17 showed the most excellent anticancer activity with single-digit micromolar IC 50 values ranging from 1.42 to 6.52 μM. Further mechanism studies revealed that compound 17 could obviously inhibit the proliferation of EC-109 cancer cells by inducing apoptosis and arresting the cell cycle at G2/M phase. [ABSTRACT FROM AUTHOR]

Published
2014
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2. Synthesis and anticancer activities of novel 1,2,4-triazolo[3,4-a]phthalazine derivatives.

Author

Xue, Deng-Qi, Zhang, Xu-Yao, Wang, Chao-Jie, Ma, Li-Ying, Zhu, Nan, He, Peng, Shao, Kun-Peng, Chen, Peng-Ju, Gu, Yi-Fei, Zhang, Xiao-Song, Wang, Cai-Feng, Ji, Cong-Hui, Zhang, Qiu-Rong, and Liu, Hong-Min

Subjects
*ANTINEOPLASTIC agents, *PHTHALAZINE, *CHEMICAL synthesis, *DRUG design, *FLUOROURACIL, *FLOW cytometry, *APOPTOSIS
Abstract

Trying to develop potent and selective anticancer agents, two series of novel 1,2,4-triazolo[3,4-a]phthalazine derivatives were designed and synthesized. Their antitumor activities were evaluated by MTT method against four selected human cancer cell lines (MGC-803, EC-9706, HeLa and MCF-7). Our results showed that compound 11h exhibited good anticancer activities compared to 5-fluorouracil against the four tested cell lines, with IC 50 values ranging from 2.0 to 4.5 μM. Flow cytometry analysis indicated that compound 11h induced the cellular early apoptosis and cell cycle arrest at G2/M phase in EC-9706. [ABSTRACT FROM AUTHOR]

Published
2014
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3. Design and synthesis of novel 1,2,3-triazole-dithiocarbamate hybrids as potential anticancer agents

Author

Duan, Ying-Chao, Ma, Yong-Cheng, Zhang, En, Shi, Xiao-Jing, Wang, Meng-Meng, Ye, Xian-Wei, and Liu, Hong-Min

Subjects
*DRUG design, *DITHIOCARBAMATES synthesis, *DRUG development, *ANTINEOPLASTIC agents, *CANCER cell culture, *FLUOROURACIL, *FLOW cytometry
Abstract

Abstract: A series of novel 1,2,3-triazole-dithiocarbamate hybrids were designed, synthesized and evaluated for anticancer activity against four selected human tumor cell lines (MGC-803, MCF-7, PC-3, EC-109). Majority of the synthesized compounds exhibited moderate to potent activity against MGC-803 and MCF-7. Among them, compounds 3a and 3c showed excellent broad spectrum anticancer activity with IC50 values ranging from 0.73 to 11.61 μM and 0.49–12.45 μM, respectively. Particularly, compound 3a was more potent than 5-fluorouracil against all tested human cancer cell lines. Flow cytometry analysis demonstrated that treatment of MGC-803 with 3c led to cell cycle arrest at G2/M phase accompanied by an increase in apoptotic cell death after 12 h. [Copyright &y& Elsevier]

Published
2013
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