1. 2-Aminoimidazole-based antagonists of the 5-HT
- Author
-
Adam S, Hogendorf, Agata, Hogendorf, Rafał, Kurczab, Justyna, Kalinowska-Tłuścik, Piotr, Popik, Agnieszka, Nikiforuk, Martyna, Krawczyk, Grzegorz, Satała, Tomasz, Lenda, Joanna, Knutelska, Ryszard, Bugno, Jakub, Staroń, Wojciech, Pietruś, Mikołaj, Matłoka, Krzysztof, Dubiel, Rafał, Moszczyński-Pętkowski, Jerzy, Pieczykolan, Maciej, Wieczorek, Bogusław, Pilarski, Paweł, Zajdel, and Andrzej J, Bojarski
- Subjects
Male ,Models, Molecular ,Dose-Response Relationship, Drug ,Molecular Structure ,Scopolamine ,Imidazoles ,Hep G2 Cells ,Rats ,Rats, Sprague-Dawley ,Structure-Activity Relationship ,HEK293 Cells ,Drug Design ,Receptors, Serotonin ,Animals ,Humans ,Cognitive Dysfunction ,Serotonin Antagonists ,Cells, Cultured - Abstract
A new strategy in the design of aminergic GPCR ligands is proposed - the use of aromatic, heterocyclic basic moieties in place of the evergreen piperazine or alicyclic and aliphatic amines. This hypothesis has been tested using a benchmark series of 5-HT
- Published
- 2018